Abstract: Methods of causing performance of commands at a computing device based on neuromuscular signals from thumb-initiated gestures are provided. A method includes receiving, by a wearable device, a sequence of neuromuscular signals indicating that a user is instructing a thumb on the user's hand to contact a portion of the user's hand. The portion of the user's hand is associated with at least one input command available at a computing device. The method further includes responsive to receiving the sequence of neuromuscular signals, providing, by the wearable device, data to cause the computing device to perform the at least one input command. The method also includes in response to receiving a second sequence of neuromuscular signals indicating that the user is instructing the thumb on the user's hand to contact the portion of the user's hand twice, providing data to cause the computing device to perform a second input command.