Patents by Inventor Tulay Polat

Tulay Polat has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrimidine derivatives as kinase inhibitors and their therapeutical applications
    Patent number: 10766879
    Abstract: The present invention provides antitumor agents comprising substituted pyrimidine derivatives and pharmaceutically-acceptable formulations thereof, methods for making novel compounds and methods for using the compounds. The compounds and compositions in accordance with the invention have utility in treatment of a variety of diseases and have kinase inhibitory activities.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: September 8, 2020
    Assignee: NANTBIOSCIENCE, INC.
    Inventors: Chunlin Tao, Qinwei Wang, Laxman Nallan, David Ho, Tulay Polat, Forrest Arp, Paul Weingarten
  • BACE1 INHIBITORS FOR TREATMENT OF ALZHEIMER'S DISEASE
    Publication number: 20200165225
    Abstract: Compounds, pharmaceutical compositions containing the same useful in the treatment of Alzheimer's disease are disclosed. Methods of preparing the compounds and compositions and use thereof are also disclosed.
    Type: Application
    Filed: May 8, 2018
    Publication date: May 28, 2020
    Applicant: NantBio, Inc.
    Inventors: Chunlin TAO, Tulay POLAT, Chengzhi YU
  • Substituted indol-5-ol derivatives and their therapeutic applications
    Patent number: 10245261
    Abstract: The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: April 2, 2019
    Assignee: NantBio, Inc.
    Inventors: Chunlin Tao, Qinwei Wang, David Ho, Tulay Polat, Laxman Nallan, Patrick Soon-Shiong
  • Substituted indol-5-ol derivatives and their therapeutical applications
    Patent number: 10160749
    Abstract: The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
    Type: Grant
    Filed: October 4, 2016
    Date of Patent: December 25, 2018
    Assignee: NantBio, Inc.
    Inventors: Chunlin Tao, Qinwei Wang, David Ho, Tulay Polat, Laxman Nallan, Patrick Soon-Shiong
  • PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THEIR THERAPEUTICAL APPLICATIONS
    Publication number: 20180215734
    Abstract: The present invention provides kinase inhibitors with anti-proliferative activity comprising substituted pyrimidine derivatives and pharmaceutically-acceptable formulations thereof. In addition, the invention provides methods for making novel compounds and methods for using the compounds.
    Type: Application
    Filed: February 29, 2016
    Publication date: August 2, 2018
    Inventors: Chunlin Tao, Qinwei Wang, Laxman Nallan, David Ho, Tulay Polat, Forrest Arp, Paul Weingarten
  • POLYCYCLIC DERIVATIVES TARGETING RAL GTPASES AND THEIR THERAPEUTICAL APPLICATIONS
    Publication number: 20180170942
    Abstract: Contemplated compounds, compositions and methods are directed to Ral GTPase inhibitors with improved activity.
    Type: Application
    Filed: June 16, 2016
    Publication date: June 21, 2018
    Inventors: Chunlin Tao, Chengzhi Yu, Tulay Polat, Chao Yan, Shahrooz Rabizadeh, Daniel Theodorescu
  • PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THEIR THERAPEUTICAL APPLICATIONS
    Publication number: 20180155327
    Abstract: The present invention provides antitumor agents comprising substituted pyrimidine derivatives and pharmaceutically-acceptable formulations thereof, methods for making novel compounds and methods for using the compounds. The compounds and compositions in accordance with the invention have utility in treatment of a variety of diseases and have kinase inhibitory activities.
    Type: Application
    Filed: February 27, 2015
    Publication date: June 7, 2018
    Inventors: Chunlin Tao, Qinwei Wang, Laxman Nallan, David Ho, Tulay Polat, Forrest Arp, Paul Weingarten
  • SUBSTITUTED INDOL-5-OL DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS
    Publication number: 20170088544
    Abstract: The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
    Type: Application
    Filed: October 4, 2016
    Publication date: March 30, 2017
    Inventors: Chunlin Tao, Qinwei Wang, David Ho, Tulay Polat, Laxman Nallan, Patrick Soon-Shiong
  • Substituted indol-5-ol derivatives and their therapeutical applications
    Patent number: 9458137
    Abstract: The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: October 4, 2016
    Assignee: NantBioScience, Inc.
    Inventors: Chunlin Tao, Qinwei Wang, David Ho, Tulay Polat, Laxman Nallan, Patrick Soon-Shiong
  • Benzyl substituted triazine derivatives and their therapeutical applications
    Patent number: 9409903
    Abstract: The invention provides triazine compounds and methods of their use to modulate protein kinases and to treat diseases mediated by said protein kinases.
    Type: Grant
    Filed: November 3, 2014
    Date of Patent: August 9, 2016
    Assignee: NantBioScience, Inc.
    Inventors: Chunlin Tao, Qinwei Wang, David Ho, Laxman Nallan, Tulay Polat, Xiaowen Sun, Neil Desai
  • SUBSTITUTED INDOL-5-OL DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS
    Publication number: 20150291564
    Abstract: The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
    Type: Application
    Filed: November 5, 2013
    Publication date: October 15, 2015
    Applicant: NantBioScience, Inc.
    Inventors: Chunlin Tao, Qinwei Wang, David Ho, Tulay Polat, Laxman Nallan, Patrick Soon-Shiong
  • Triazine derivatives and their therapeutical applications
    Patent number: 9078902
    Abstract: The invention provides Triazine derivatives and further provides methods of using these compounds to modulate protein kinases and for treating diseases and conditions mediated by protein kinases.
    Type: Grant
    Filed: June 9, 2010
    Date of Patent: July 14, 2015
    Assignee: NantBioScience, Inc.
    Inventors: Chunlin Tao, Qinwei Wang, Laxman Nallan, Tulay Polat, David Ho, Neil Desai
  • BENZYL SUBSTITUTED TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS
    Publication number: 20150057285
    Abstract: The invention provides triazine compounds and methods of their use to modulate protein kinases and to treat diseases mediated by said protein kinases.
    Type: Application
    Filed: November 3, 2014
    Publication date: February 26, 2015
    Inventors: Chunlin Tao, Qinwei Wang, David Ho, Laxman Nallan, Tulay Polat, Xiaowen Sun, Neil Desai
  • Benzyl substituted triazine derivatives and their therapeutical applications
    Patent number: 8877924
    Abstract: The invention provides triazine compounds and methods of their use to modulate protein kinases and to treat diseases mediated by said protein kinases.
    Type: Grant
    Filed: June 8, 2010
    Date of Patent: November 4, 2014
    Assignee: NantBio Inc.
    Inventors: Chunlin Tao, Qinwei Wang, David Ho, Laxman Nallan, Tulay Polat, Xiaowen Sun, Neil Desai
  • Triazine Derivatives and their Therapeutical Applications
    Publication number: 20130023497
    Abstract: The present invention comprises inter alia triazine compounds as shown in formula (I) and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: June 7, 2010
    Publication date: January 24, 2013
    Inventors: Chunlin Tao, Qinwei Wang, Tulay Polat, Laxman Nallan, Neil Desai
  • BENZYL SUBSTITUTED TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS
    Publication number: 20120264759
    Abstract: The invention provides triazine compounds and methods of their use to modulate protein kinases and to treat diseases mediated by said protein kinases.
    Type: Application
    Filed: June 8, 2010
    Publication date: October 18, 2012
    Applicant: CALIFORNIA CAPITAL EQUITY, LLC
    Inventors: Chunlin Tao, Qinwei Wang, David Ho, Laxman Nallan, Tulay Polat, Xiaowen Sun, Neil Desai
  • Triazine Derivatives and their Therapeutical Applications
    Publication number: 20120238576
    Abstract: The present invention comprises inter alia compounds as shown in formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: June 7, 2010
    Publication date: September 20, 2012
    Applicant: CALIFORNIA CAPITAL EQUITY, LLC
    Inventors: Chunlin Tao, Qinwei Wang, Laxman Nallan, Tulay Polat, Lukasz Koroniak, Neil Desai
  • Triazine derivatives and their therapeutical applications
    Publication number: 20120196860
    Abstract: The invention provides Triazine derivatives and further provides methods of using these compounds to modulate protein kinases and for treating diseases and conditions mediated by protein kinases.
    Type: Application
    Filed: June 9, 2010
    Publication date: August 2, 2012
    Applicant: CALIFORNIA CAPITAL EQUITY, LLC
    Inventors: Chunlin Tao, Qinwei Wang, Laxman Nallan, Tulay Polat, David Ho, Neil Desai
  • TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS
    Publication number: 20120172361
    Abstract: Compounds of the formula (I) and formula (II) and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: June 7, 2010
    Publication date: July 5, 2012
    Applicant: CALIFORNIA CAPITAL EQUITY, LLC
    Inventors: Chunlin Tao, Qinwei Wang, Tulay Polat, Laxman Nallan, David Ho, Neil Desai
  • Method for synthesizing C-glycosides of ulosonic acids
    Patent number: 6590110
    Abstract: The invention is directed to a method for synthesizing C-glycosides of ulosonic acids, as well as intermediates thereof and C-glycosides prepared by this method.
    Type: Grant
    Filed: May 17, 2001
    Date of Patent: July 8, 2003
    Assignee: University of Iowa Research Foundation
    Inventors: Robert J. Linhardt, Tulay Polat, Yuguo Du