Patents by Inventor Tully Michael Underhill

Tully Michael Underhill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITION AND USE OF RAR ANTAGONISTS FOR PROMOTING CHONDROGENESIS
    Publication number: 20100003307
    Abstract: The invention provides compositions comprising a RAR antagonist for promoting chondrogenesis and to methods employing such compositions for treating cartilage and associated bone abnormalities resulting from injury or disease and for ex vivo tissue engineering.
    Type: Application
    Filed: September 14, 2009
    Publication date: January 7, 2010
    Inventors: Tully Michael UNDERHILL, Andrea Dawn WESTON
  • Composition and use of RAR antagonists for promoting chondrogenesis
    Patent number: 7608281
    Abstract: The invention provides compositions comprising a RAR antagonist for promoting chondrogenesis and to methods employing such compositions for treating cartilage and associated bone abnormalities resulting from injury or disease and for ex vivo tissue engineering.
    Type: Grant
    Filed: January 12, 2007
    Date of Patent: October 27, 2009
    Assignee: T. Michael Underhill
    Inventors: Tully Michael Underhill, Andrea Dawn Weston
  • Composition and use of RAR antagonists for promoting chondrogenesis
    Patent number: 7186418
    Abstract: The invention provides compositions comprising an RAR antagonist for promoting chondrogenesis and methods employing such compositions for treating cartilage and associated bone abnormalities resulting from injury or disease and for ex vivo tissue engineering.
    Type: Grant
    Filed: November 19, 1999
    Date of Patent: March 6, 2007
    Assignee: University of Western Ontario
    Inventors: Tully Michael Underhill, Andrea Dawn Weston
  • Assay for identifying modulators of chondrogenesis
    Publication number: 20020061514
    Abstract: A screening assay for identifying modulators of chondrogenesis is described. The assay comprises providing cells capable of differentiating into chondroblasts; transfecting the cells with a nucleic acid construct comprising a reporter gene that is detectable upon chondroblast differentiation; adding a test compound to the transfected cells; and determining the effect of the test compound on chondroblast differentiation. The reporter gene is preferably responsive to the transcription factor Sox9. The modulators may be useful as therapeutic agents that can inhibit or enhance cartilage formation. The assay may also be used to diagnose, monitor or prognose diseases associated with abnormal cartilage formation.
    Type: Application
    Filed: September 21, 2001
    Publication date: May 23, 2002
    Inventors: Tully Michael Underhill, Andrea Dawn Weston