Abstract: A system, method, and computer program product are provided for optimizing use of a vertex cache. In use, information is identified, where such information is associated with vertex data stored in a vertex cache. To this end, use of the vertex cache may be optimized utilizing the information. In one embodiment, the information may include new information derived from the vertex data, and optionally index data, prior to processing of the vertex data. Further, the vertex cache may optionally utilize the information to optimize performance of the vertex cache by minimizing a number of cache misses.