Patents by Inventor Tuomas Tammela

Tuomas Tammela has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR IDENTIFYING AND TREATING HIGH-PLASTICITY CELL STATE DRIVING TUMOR PROGRESSION IN LUNG CANCER
    Publication number: 20220259673
    Abstract: The present disclosure provides methods for detecting and inhibiting high-plasticity cell state (HPCS) in patients diagnosed with or at risk for lung cancer. Also disclosed herein are methods for reducing the expression and/or activity of SLC4A11, OC2, MYC, RELB, LIF, NFKB2, FOSL2, ATF4, and/or YAP to inhibit HPCS in lung cancer.
    Type: Application
    Filed: February 8, 2022
    Publication date: August 18, 2022
    Inventor: Tuomas TAMMELA
  • THERAPEUTIC USE OF VEGFR-3 LIGANDS
    Publication number: 20160331807
    Abstract: The present invention relates to therapeutic methods, uses and compositions for treating glaucoma or ocular hypertension. More specifically, the present invention relates to methods, uses and compositions utilizing VEGFR-3 activating ligand VEGF-C.
    Type: Application
    Filed: January 20, 2015
    Publication date: November 17, 2016
    Applicant: UNIVERSITY OF HELSINKI
    Inventors: Kari ALITALO, Aleksanteri ASPELUND, Tuomas TAMMELA, Ilkka IMMONEN
  • Materials and Methods for the Treatment of Hypertension
    Publication number: 20120141424
    Abstract: The present invention is directed to materials and methods for the treatment of hypertension and ischemia comprising administering at least one therapeutic agent selected from the group consisting of vascular endothelial growth factor-C product and vascular endothelial growth factor-D product, and optionally, when treating hypertension, a standard of care anti-hypertensive agent.
    Type: Application
    Filed: January 7, 2010
    Publication date: June 7, 2012
    Applicant: VEGENICS PTY LIMITED
    Inventors: Kari Alitalo, Tuomas Tammela, Georgia Zarkada, Denis Tvorogov
  • AUTOLOGOUS LYMPH NODE TRANSFER IN COMBINATION WITH VEGF-C OR VEGF-D GROWTH FACTOR THERAPY TO TREAT SECONDARY LYMPHEDEMA AND TO IMPROVE RECONSTRUCTIVE SURGERY
    Publication number: 20120125348
    Abstract: The present invention provides materials and methods for repairing tissue and using vascular endothelial growth factor C (VEGF-C) genes and/or proteins. Methods and materials related to the use of VEGF-C for the reduction of edema and improvement of skin perfusion is provided. Also provided is are materials and methods for using VEGF-C before, during, and after reconstructive surgery.
    Type: Application
    Filed: October 21, 2011
    Publication date: May 24, 2012
    Applicant: VEGENICS LIMITED
    Inventors: KARI ALITALO, Anne Saaristo, Tuomas Tammela
  • MODIFIED VEGF-A WITH IMPROVED ANGIOGENIC PROPERTIES
    Publication number: 20120071406
    Abstract: The present invention is directed to methods and compositions for making and using chimeric polypeptides that comprise a VEGFR-2 ligand. The chimeric molecules of the present invention retain VEGFR-2 binding activity and an enhanced angiogenic activity as compared to native VEGF-A.
    Type: Application
    Filed: August 19, 2011
    Publication date: March 22, 2012
    Applicant: VEGENICS PTY LIMITED
    Inventors: KARI ALITALO, Tuomas Tammela, Salla Keskitalo, Katri Pajusola, Markku M. Jeltsch, Seppo Yla-Herttuala, Terhi Karpanen, Ulf Eriksson, Marko J. T. Uutela
  • Modified VEGF-A with improved angiogenic properties
    Patent number: 8025886
    Abstract: The present invention is directed to methods and compositions for making and using chimeric polypeptides that comprise a VEGFR-2 ligand. The chimeric molecules of the present invention retain VEGFR-2 binding activity and an enhanced angiogenic activity as compared to native VEGF-A.
    Type: Grant
    Filed: August 15, 2006
    Date of Patent: September 27, 2011
    Assignee: Vegenics Pty Ltd
    Inventors: Kari Alitalo, Tuomas Tammela, Salla Keskitalo, Katri Pajusola, Markku M. Jeltsch, Seppo Yla-Herttuala, Terhi Karpanen, Ulf Eriksson, Marko J. T. Uutela
  • Use of VEGF-C or VEGF-D in Reconstructive Surgery
    Publication number: 20100041605
    Abstract: The present invention provides materials and methods for repairing tissue and using vascular endothelial growth factor C (VEGF-C) genes and/or proteins. Methods and materials related to the use of VEGF-C for the reduction of edema and improvement of skin perfusion is provided. Also provided is are materials and methods for using VEGF-C before, during, and after reconstructive surgery.
    Type: Application
    Filed: June 23, 2009
    Publication date: February 18, 2010
    Applicant: Vegenics Limited
    Inventors: Kari Alitalo, Anne Saaristo, Marika Karkkainen, Tuomas Tammela, Sirpa Asko-Seljavaara, Seppo Yla-Herttuala, Yulong He
  • AUTOLOGOUS LYMPH NODE TRANSFER IN COMBINATION WITH VEGF-C OR VEGF-D GROWTH FACTOR THERAPY TO TREAT SECONDARY LYMPHEDEMA AND TO IMPROVE RECONSTRUCTIVE SURGERY
    Publication number: 20080267924
    Abstract: The present invention provides materials and methods for repairing tissue and using vascular endothelial growth factor C (VEGF-C) genes and/or proteins. Methods and materials related to the use of VEGF-C for the reduction of edema and improvement of skin perfusion is provided. Also provided is are materials and methods for using VEGF-C before, during, and after reconstructive surgery.
    Type: Application
    Filed: February 7, 2008
    Publication date: October 30, 2008
    Applicant: VEGENICS LIMITED
    Inventors: Kari Alitalo, Anne Saaristo, Tuomas Tammela
  • Use of VEGF-C or VEGF-D in Reconstructive Surgery
    Publication number: 20080147045
    Abstract: The present invention provides materials and methods for repairing tissue and using vascular endothelial growth factor C (VEGF-C) genes and/or proteins. Methods and materials related to the use of VEGF-C for the reduction of edema and improvement of skin perfusion is provided. Also provided is are materials and methods for using VEGF-C before, during, and after reconstructive surgery.
    Type: Application
    Filed: July 24, 2007
    Publication date: June 19, 2008
    Applicants: Licentia Ltd., Ludwig Institute for Cancer Research
    Inventors: Kari Alitalo, Anne Saaristo, Marika Karkkainen, Tuomas Tammela, Sirpa Asko-Seljavaara, Seppo Yla-Herttuala, Yulong He
  • Modified VEGF-A with improved angiogenic properties
    Publication number: 20070142282
    Abstract: The present invention is directed to methods and compositions for making and using chimeric polypeptides that comprise a VEGFR-2 ligand. The chimeric molecules of the present invention retain VEGFR-2 binding activity and an enhanced angiogenic activity as compared to native VEGF-A.
    Type: Application
    Filed: August 15, 2006
    Publication date: June 21, 2007
    Applicants: LUDWIG INSTITUTE FOR CANCER RESEARCH, LICENTIA LTD.
    Inventors: Kari Alitalo, Tuomas Tammela, Salla Keskitalo, Katri Pajusola, Markku Jeltsch, Seppo Yla-Herttuala, Terhi Karpanen, Ulf Eriksson, Marko Uutela
  • Use of VEGF-C or VEGF-D in reconstructive surgery
    Publication number: 20050043235
    Abstract: The present invention provides materials and methods for repairing tissue and using vascular endothelial growth factor C (VEGF-C) genes and/or proteins. Methods and materials related to the use of VEGF-C for the reduction of edema and improvement: of skin perfusion is provided. Also provided is are materials and methods for using VEGF-C before, during, and after reconstructive surgery.
    Type: Application
    Filed: June 14, 2004
    Publication date: February 24, 2005
    Inventors: Kari Alitalo, Anne Saaristo, Marika Karkkainen, Tuomas Tammela, Sirpa Asko-Seljavaara, Seppo Yla-Herttuala, Yulong He