Abstract: Methods of detecting nucleic acids, including methods of detecting two or more nucleic acids in multiplex branched-chain DNA assays, are provided. Nucleic acids captured on a solid support are detected, for example, through cooperative hybridization events that result in specific association of a label with the nucleic acids. Compositions, kits, and systems related to the methods are also described.

Abstract: A method for processing a call placed to a telephony identifier. The method comprises: obtaining information regarding an origin of the call; identifying a group of identities that is associated with the telephony identifier, each identity designating a party reachable by calling the telephony identifier; determining, based on the information regarding the origin of the call, that the call is intended for a particular identity among the group of identities; and causing routing of the call based on information associated with the particular identity. The party designated by each identity may be a different person. Also provided a system for processing a call placed to a telephony identifier.

Abstract: A suture passer including a tubular member having a proximal end and a distal end and a central axis defined therethrough, in which the tubular member includes at least one lumen formed therein, an eyelet configured to receive a suture, a movable jaw formed on the distal end of the tubular member configured to move between an open position and a closed position, in which the movable jaw includes a plurality of portions, and an actuator configured to be received within the at least one lumen of the tubular member, in which the actuator is configured to move along the central axis of the tubular member between a first position and a second position, in which, in the first position, the movable jaw is in the closed position, and in which, in the second position, the movable jaw is in the open position.

Abstract: The present invention provides fused ring heterocycles as kinase modulators, pharmaceutical compositions containing these modulators, and methods of using these modulators to treat diseases mediated by kinase activity.

Abstract: Methods of detecting various types of nucleic acids, including methods of detecting two or more nucleic acids in multiplex branched-chain DNA assays, are provided. Detection assays may be conducted at least in vitro, in cellulo, and in situ. Nucleic acids which are optionally captured on a solid support are detected, for example, through cooperative hybridization events that result in specific association of a label probe system with the nucleic acids. Various label probe system embodiments are provided. Compositions, kits, and systems related to the methods are also described.

Abstract: Methods of detecting various types of nucleic acids, including methods of detecting two or more nucleic acids in multiplex branched-chain DNA assays, are provided. Detection assays may be conducted at least in vitro, in cellulo, and in situ. Nucleic acids which are optionally captured on a solid support are detected, for example, through cooperative hybridization events that result in specific association of a label probe system with the nucleic acids. Various label probe system embodiments are provided. Compositions, kits, and systems related to the methods are also described.

Abstract: Devices, systems and methods for separation of magnetic particles with either hand held devices or automated instruments. Specifically, the production of magnetic fields for the separation of the particles within containers such as microtiter plates with a magnetic field that is substantially consistent for each well. Certain embodiments produce a magnetic field that is substantially uniform across each well bottom, while other embodiments produce a magnetic field that is stronger toward the outer region of each well.

Abstract: The present disclosure relates to an anchor assembly. The anchor assembly includes an anchor defining a cavity and an opening to the cavity; and a headless insertion member configured for arrangement within the anchor cavity, the insertion member including a body having a threaded proximal portion, a non-threaded distal portion, and a cannulation extending a partial length of the insertion member. Other anchor assemblies, anchors, and delivery devices are also disclosed.

Abstract: Methods of detecting nucleic acids, including methods of detecting two or more nucleic acids in multiplex branched-chain DNA assays, are provided. Nucleic acids captured on a solid support are detected, for example, through cooperative hybridization events that result in specific association of a label with the nucleic acids. Compositions, kits, and systems related to the methods are also described.

Abstract: Methods of detecting nucleic acids, including methods of detecting two or more nucleic acids in multiplex branched-chain DNA assays, are provided. Nucleic acids captured on a solid support are detected, for example, through cooperative hybridization events that result in specific association of a label with the nucleic acids. Compositions, kits, and systems related to the methods are also described.

Abstract: A system and a method for processing calls. The system comprises a database including: a plurality of telephony identifiers; and for each telephony identifier, information regarding a group of persons that is associated with the telephony identifier, each person of the group of persons being reachable by placing a call to the telephony identifier, the information comprising, for each person of the group of persons, information related to processing of calls involving the person. The system also comprises a processing element having access to the database and being operative for: determining that a given call involves a particular person of the group of persons that is associated with a given one of the telephony identifiers: and processing the given call based on the information related to processing of calls involving the particular person.

Abstract: A method for processing a call placed to a telephony identifier. The method comprises: obtaining information regarding an origin of the call; identifying a group of identities that is associated with the telephony identifier, each identity designating a party reachable by calling the telephony identifier; determining, based on the information regarding the origin of the call, that the call is intended for a particular identity among the group of identities; and causing routing of the call based on information associated with the particular identity. The party designated by each identity may be a different person. Also provided a system for processing a call placed to a telephony identifier.

Abstract: A method for allowing a calling party to leave a message for a called party. The method comprises: receiving a command provided by the calling party and indicative of a desire of the calling party to leave a message for the called party; obtaining message destination information associated with the called party; receiving a voice message provided by the calling party; generating an electronic message representative of the voice message; and causing transmission of the electronic message based on the message destination information. An apparatus for implementing the method is also provided.

Abstract: Methods of detecting nucleic acids, including methods of detecting two or more nucleic acids in multiplex branched-chain DNA assays, are provided. Nucleic acids captured on a solid support are detected, for example, through cooperative hybridization events that result in specific association of a label with the nucleic acids. Compositions, kits, and systems related to the methods are also described.

Abstract: The present invention provides fused ring heterocycles as kinase modulators, pharmaceutical compositions containing these modulators, and methods of using these modulators to treat diseases mediated by kinase activity.

Abstract: Methods of detecting nucleic acids, including methods of detecting two or more nucleic acids in multiplex branched-chain DNA assays, are provided. Nucleic acids captured on a solid support are detected, for example, through cooperative hybridization events that result in specific association of a label with the nucleic acids. Compositions, kits, and systems related to the methods are also described.

Abstract: The invention provides isolated nucleic acids that encode RGL3, and fragments thereof, vectors for propagating and expressing RGL3 nucleic acids, host cells comprising the nucleic acids and vectors of the present invention, proteins, protein fragments, and protein fusions of the novel RGL3 isoforms, and antibodies thereto. The invention further provides transgenic cells and non-human organisms comprising human RGL3 nucleic acids, and transgenic cells and non-human organisms with targeted disruption of the endogenous orthologue of the human RGL3 gene. The invention further provides pharmaceutical formulations of the nucleic acids, proteins, and antibodies of the present invention, and diagnostic, investigational, and therapeutic methods based on the RGL3 nucleic acids, proteins, and antibodies of the present invention.

Abstract: A method of forwarding a call properly for a wireless terminal when the wireless terminal is roaming in a different region (or country) than where its home location register resides is disclosed. In particular, this is accomplished by having the home location register and the serving wireless switching system implement procedures for internationalizing, when appropriate, forward-to numbers, and for nationalizing, when appropriate the same forward-to numbers.

Abstract: The invention provides isolated nucleic acids that encode MDZ3, MDZ4, MDZ7 and MDZ12, and fragments thereof, vectors for propagating and expressing MDZ3, MDZ4, MDZ7 and MDZ12 nucleic acids, host cells comprising the nucleic acids and vectors of the present invention, proteins, protein fragments, and protein fusions of the novel MDZ3, MDZ4, MDZ7 and MDZ12 isoforms, and antibodies thereto. The invention further provides transgenic cells and non-human organisms comprising human MDZ3, MDZ4, MDZ7 and MDZ12 nucleic acids, and transgenic cells and non-human organisms with targeted disruption of the endogenous orthologue of the human MDZ3, MDZ4, MDZ7 or MDZ12 gene. The invention further provides pharmaceutical formulations of the nucleic acids, proteins, and antibodies of the present invention, and diagnostic, investigational, and therapeutic methods based on the MDZ3, MDZ4, MDZ7 or MDZ12 nucleic acids, proteins, and antibodies of the present invention.

Abstract: A stabilized fluid conductivity measurement system includes a threaded metal housing with an inner portion having two probes for contacting the fluid to be measured and having an outer portion in which electrical circuitry is mounted. The circuitry includes a balanced square wave generator providing excitation to a modified Wheatstone bridge, including first and second input excitation terminals, and first and second output terminals. Fixed resistances may be located in 3 arms of the Wheatstone bridge, and the fourth arm may have two resistances with an intermediate tap; and one of the two probes is connected to this tap while the other probe is connected to one of the input excitation points.