Abstract: The present invention relates to a blood flow restriction system, comprising: —a tourniquet cuff (C) or band to be placed around a limb, proximally to a target muscle, tightened so as to apply a specific pressure during a blood flow restriction exercise regimen; and —measuring and monitoring means (M, P) made and arranged to measure and monitor microvascular blood flow within the target muscle, to guide safety and performance parameters of the blood flow restriction exercise regimen according to hemodynamic criteria. The present invention also relates to a method adapted to use the system of the invention, and to a computer program with code instructions to implement the steps of the method of the invention.

Abstract: System and computer-implemented method for detecting and categorizing pathologies through an analysis of pulsatile blood flow. The method has a pulsatile blood flow signal of a subject, extracting a set of features from the pulsatile blood flow signal; and categorizing a pathology based on the extracted features. The extracted features may be predetermined features or features learned through a machine learning algorithm. For the categorization, a classification or a regression algorithm may be used to provide an index or a value score as a biomarker. Additional static features of the subject may be used in the categorization.

Abstract: Speckle contrast method and system that discriminates photons based on their path length in tissue, the method comprising the steps of: directing light from a pulsed light into a sample by optical elements; synchronizing the time between the pulse injection to sample and the detection unit; collecting the photons that have travelled through the sample by optics, and conveying the photons of a single or a limited number of speckles from the sample to one or more detection elements; time-tagging photons thanks to the synchronization of the detector element and/or the time-tagging electronics with the laser pulse emission; estimating each photon time-of-flight by the difference between its time tag and the laser pulse emission; categorizing the detected photons based on the value of the time-of-flight in a certain number of time gates; measuring the speckle contrast.

Abstract: Speckle contrast method and system that discriminates photons based on their path length in tissue, the method comprising the steps of: directing light from a pulsed light into a sample by optical elements; synchronizing the time between the pulse injection to sample and the detection unit; collecting the photons that have travelled through the sample by optics, and conveying the photons of a single or a limited number of speckles from the sample to one or more detection elements; time-tagging photons thanks to the synchronization of the detector element and/or the time-tagging electronics with the laser pulse emission; estimating each photon time-of-flight by the difference between its time tag and the laser pulse emission; categorizing the detected photons based on the value of the time-of-flight in a certain number of time gates; measuring the speckle contrast

Abstract: System and computer-implemented method for detecting and categorizing pathologies through an analysis of pulsatile blood flow. The method has a pulsatile blood flow signal of a subject, extracting a set of features from the pulsatile blood flow signal; and categorizing a pathology based on the extracted features. The extracted features may be predetermined features or features learned through a machine learning algorithm. For the categorization, a classification or a regression algorithm may be used to provide an index or a value score as a biomarker. Additional static features of the subject may be used in the categorization.

Abstract: Speckle contrast optical tomography system provided with at least one point source and multiple detectors, means for providing different source positions, the point source having a coherence length of at least the source position-detector distance and means for arranging the source position-detector pairs over a sample to be inspected, the system being further provided with means for measuring the speckle contrast; the speckle contrast system of the invention thus capable of obtaining 3D images.

Abstract: Speckle contrast optical tomography system provided with at least one point source and multiple detectors, means for providing different source positions, the point source having a coherence length of at least the source position-detector distance and means for arranging the source position-detector pairs over a sample to be inspected, the system being further provided with means for measuring the speckle contrast; the speckle contrast system of the invention thus capable of obtaining 3D images.

Abstract: An embodiment of the invention includes a device, system and method for determining the characteristics of deep tissue. The novel method includes measuring blood flow rate and oxygenation characteristics of the tissue, and determining oxygen metabolism of the tissue as a function of the measure blood flow rate and measure oxygenation. The blood flow rate characteristics are measured as a function of light fluctuations caused by the tissue, while the oxygenation characteristics are measured as a function of transmission of light through the tissue with respect to the wavelength of light. The tissue may be layered tissue, for example, a portion of a brain. The tissue characteristics may be measured during times of varying levels of exercise intensity.

Abstract: An embodiment of the invention includes a device, system and method for determining the characteristics of deep tissue. The novel method includes measuring blood flow rate and oxygenation characteristics of the tissue, and determining oxygen metabolism of the tissue as a function of the measure blood flow rate and measure oxygenation. The blow flow rate characteristics are measured as a function of light fluctuations caused by the tissue, while the oxygenation characteristics are measured as a function of transmission of light through the tissue with respect to the wavelength of light. The tissue may be layered tissue, for example, a portion of a brain. The tissue characteristics may be measured during times of varying levels of exercise intensity.