Abstract: Bioactive molecules have been coated on nanotubular structured titanium substrates by molecular plasma deposition. The coatings promote cell adhesion and are particularly suited for orthopedic implants that provide improved bone cell adhesion and new tissue growth. Nanodimensional features on titanium substrates are engineered using electrochemical anodization techniques. The nanostructured surfaces provide superior support for a wide selection of polypeptide coatings.

Abstract: Nanotubular structured titanium (Ti) substrates have been coated with nanoparticulate hydroxyapatite (nano-HA). The nano-HA surface is highly adherent to the nanotubular Ti surface and is free of microparticles. The nano-HA coated nanotubular Ti surface promotes osteoblast cell adhesion and is particularly suitable for orthopedic and dental implants where deposition of osteoblasts and other proteins is important in bone formation.

Abstract: Substrates coated with several classes of bioactive agents, including antimicrobial agents, are described. The coating technique is based on a molecular plasma discharge deposition method such that the deposited materials retain biological activity and/or structure. The deposited biomaterials can be selected for a variety of medical uses, including coated implants for in situ release of pharmaceuticals.

Abstract: A molecular plasma discharge deposition method for depositing colloidal suspensions of biomaterials such as amino acids or other carbon based substances onto metal or nonmetal surfaces without loss of biological activity and/or structure is described. The method is based on generating a charged corona plasma which is then introduced into a vacuum chamber to deposit the biomaterial onto a biased substrate. The deposited biomaterials can be selected for a variety of medical uses, including coated implants for in situ release of pharmaceuticals.