Patents by Inventor Twinkle R. Christian

Twinkle R. Christian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods directed to crystalline biomolecules
    Patent number: 11958882
    Abstract: Disclosed herein are methods of preparing a composition comprising crystalline biomolecules, for example, crystalline antibodies. In exemplary embodiments, the method comprises forming a fluidized bed of crystalline biomolecules using, for example, a counter-flow centrifuge to exchange buffer and/or to concentrate the crystalline biomolecules in a solution. Also provided are methods of detecting crystalline biomolecules and/or amorphous biomolecules in a sample.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: April 16, 2024
    Assignee: AMGEN INC.
    Inventors: Rizwan Sharnez, William Trieu, Marc A. Caporini, Ron C. Kelly, Neill Burt, Laura Nicholson, Twinkle R. Christian
  • METHOD OF MAKING LYOPHILIZED PROTEIN FORMULATIONS
    Publication number: 20230310324
    Abstract: Disclosed herein are methods of preparing lyophilized formulations comprising a protein, such as an antibody or a bispecific antibody construct, that exhibits improved storage stability.
    Type: Application
    Filed: September 14, 2021
    Publication date: October 5, 2023
    Inventors: Arnold McAuley, Michael J. Treuheit, Twinkle R. Christian, Bharadwaj Jagannathan
  • Crystalline antibody formulations
    Patent number: 11773184
    Abstract: Described herein are anti-PCSK9 antibody crystals, methods of making such antibody crystals and formulations comprising the antibody crystals.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: October 3, 2023
    Inventors: Twinkle R. Christian, Christi L. Clogston, Timothy David Osslund
  • PHARMACEUTICAL FORMULATION
    Publication number: 20230167176
    Abstract: Described herein are stable high concentration bispecific antibody construct formulations, wherein the formulations have less than 2% high molecular weight species of the bispecific antibody construct in the formulation under storage conditions at various time points.
    Type: Application
    Filed: April 28, 2021
    Publication date: June 1, 2023
    Applicant: AMGEN INC.
    Inventors: Twinkle R. Christian, Bharadwaj Jagannathan
  • PHARMACEUTICAL FORMULATION
    Publication number: 20230167175
    Abstract: The present disclosure describes stable aqueous formulations comprising, e.g., a bispecific antibody construct, a buffer, a saccharide and a surfactant, the formulation having a pH 4.8-5.5.
    Type: Application
    Filed: April 28, 2021
    Publication date: June 1, 2023
    Inventors: Twinkle R. Christian, Bharadwaj Jagannathan, Andrew Dykstra
  • SYSTEMS AND APPROACHES FOR DRUG DELIVERY
    Publication number: 20220362104
    Abstract: An approach for determining material compatibility for components of a drug delivery system is provided that includes using surface zeta-potential analytical method to evaluate surface interactions between a desired molecule and at least one material present within a given IV-bag system.
    Type: Application
    Filed: October 23, 2020
    Publication date: November 17, 2022
    Inventors: Cornelius Pompe, Nicholas J. Clark, Wei Qi, Arnold J. McAuley, MIchael Schneider, Chia-Jung Wu, Twinkle R. Christian, Heather N. Franey, Bharadwaj Jagannathan, Jeffrey Abel, Franz Dietzel
  • Reduced viscosity protein pharmaceutical formulations
    Patent number: 11459401
    Abstract: Described herein are therapeutic protein formulations comprising N-methyl pyrrolidone (NMP), methods related to reducing viscosity of pharmaceutical formulations and methods related to stabilizing pharmaceutical formulations using NMP.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: October 4, 2022
    Assignee: Amgen Inc.
    Inventors: Alona Teran, Qahera Munaim, Nazer Khalaf, Rahul Rajan Kaushik, Christi L. Clogston, Twinkle R. Christian, William J. Callahan
  • Anti-Sclerostin Antibody Formulations
    Publication number: 20220275073
    Abstract: The present disclosure is directed to pharmaceutical compositions comprising an anti-sclerostin antibody.
    Type: Application
    Filed: August 7, 2020
    Publication date: September 1, 2022
    Inventor: Twinkle R. Christian
  • LOW PH PHARMACEUTICAL ANTIBODY FORMULATION
    Publication number: 20210047407
    Abstract: The present disclosure describes low pH formulations comprising, e.g., an antigen-binding protein that binds CD3, at least one buffer agent, at least one saccharide and at least one surfactant.
    Type: Application
    Filed: February 8, 2019
    Publication date: February 18, 2021
    Inventors: Twinkle R. Christian, Daxian Shan
  • CRYSTALLINE ANTIBODY FORMULATIONS
    Publication number: 20200299410
    Abstract: Described herein are anti-PCSK9 antibody crystals, methods of making such antibody crystals and formulations comprising the antibody crystals.
    Type: Application
    Filed: February 24, 2020
    Publication date: September 24, 2020
    Applicant: AMGEN INC.
    Inventors: Twinkle R. CHRISTIAN, Christi L. CLOGSTON, Timothy David OSSLUND
  • METHODS DIRECTED TO CRYSTALLINE BIOMOLECULES
    Publication number: 20200157141
    Abstract: Disclosed herein are methods of preparing a composition comprising crystalline biomolecules, for example, crystalline antibodies. In exemplary embodiments, the method comprises forming a fluidized bed of crystalline biomolecules using, for example, a counter-flow centrifuge to exchange buffer and/or to concentrate the crystalline biomolecules in a solution. Also provided are methods of detecting crystalline biomolecules and/or amorphous biomolecules in a sample.
    Type: Application
    Filed: March 14, 2018
    Publication date: May 21, 2020
    Inventors: Rizwan Sharnez, William Trieu, Marc A. Caporini, Ron C. Kelly, Neill Burt, Laura Nicholson, Twinkle R. Christian
  • Crystalline antibody formulations
    Patent number: 10611850
    Abstract: Described herein are anti-PCSK9 antibody crystals, methods of making such antibody crystals and formulations comprising the antibody crystals.
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: April 7, 2020
    Assignee: Amgen Inc.
    Inventors: Twinkle R. Christian, Christi L. Clogston, Timothy David Osslund
  • REDUCED VISCOSITY PROTEIN PHARMACEUTICAL FORMULATIONS
    Publication number: 20200024363
    Abstract: Described herein are therapeutic protein formulations comprising N-methyl pyrrolidone (NMP), methods related to reducing viscosity of pharmaceutical formulations and methods related to stabilizing pharmaceutical formulations using NMP.
    Type: Application
    Filed: October 6, 2017
    Publication date: January 23, 2020
    Inventors: Alona Teran, Qahera Muniam, Nazer Khalaf, Rahul Rajan Kaushik, Christi L. Clogston, Twinkle R. Christian, William J. Callahan
  • CRYSTALLINE ANTIBODY FORMULATIONS
    Publication number: 20170198058
    Abstract: Described herein are anti-PCSK9 antibody crystals, methods of making such antibody crystals and formulations comprising the antibody crystals.
    Type: Application
    Filed: July 13, 2015
    Publication date: July 13, 2017
    Inventors: Twinkle R. CHRISTIAN, Christi L. CLOGSTON, Timothy David OSSLUND
  • Sclerostin antibody crystals and formulations thereof
    Patent number: 9617333
    Abstract: Described herein are anti-sclerostin antibody crystals, methods of making such antibody crystals and formulations comprising the antibody crystals.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: April 11, 2017
    Assignee: AMGEN INC.
    Inventors: Christi L. Clogston, Twinkle R. Christian, Timothy D. Osslund, Elisabeth Freeman
  • SCLEROSTIN ANTIBODY CRYSTALS AND FORMULATIONS THEREOF
    Publication number: 20160083460
    Abstract: Described herein are anti-sclerostin antibody crystals, methods of making such antibody crystals and formulations comprising the antibody crystals.
    Type: Application
    Filed: August 21, 2015
    Publication date: March 24, 2016
    Inventors: Christi L. Clogston, Twinkle R. Christian, Timothy D. Osslund, Elisabeth Freeman
  • Sclerostin antibody crystals and formulations thereof
    Patent number: 9145457
    Abstract: Described herein are anti-sclerostin antibody crystals, methods of making such antibody crystals and formulations comprising the antibody crystals.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: September 29, 2015
    Assignee: AMGEN INC.
    Inventors: Christi L. Clogston, Twinkle R. Christian, Timothy David Osslund, Elisabeth Freeman