Patents by Inventor Tyler Ames

Tyler Ames has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phosphaplatin compounds as immuno-modulatory agents and therapeutic uses thereof
    Patent number: 11439619
    Abstract: Use of (pyrophosphato)platinum(II) or platinum(IV) complexes (“phosphaplatins”), especially 1,2-cyclohexanediamine(pyrophosphato) platinum(II), as immunogenic cell death (ICD) inducing agents and their combination with immune checkpoint protein inhibitors for treatment of cancers, and the mechanistic rationale for the methods thereof, are disclosed.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: September 13, 2022
    Assignee: Phosplatin Therapeutics Inc.
    Inventors: Tyler Ames, Matthew Price
  • Phosphaplatin Compounds as Immuno-Modulatory Agents and Therapeutic Uses Thereof
    Publication number: 20210121434
    Abstract: Use of (pyrophosphato)platinum(II) or platinum(IV) complexes (“phosphaplatins”), especially 1,2-cyclohexanediamine(pyrophosphato) platinum(II), as immunogenic cell death (ICD) inducing agents and their combination with immune checkpoint protein inhibitors for treatment of cancers, and the mechanistic rationale for the methods thereof, are disclosed.
    Type: Application
    Filed: September 7, 2018
    Publication date: April 29, 2021
    Applicant: Phosplatin Therapeutics LLC
    Inventors: Tyler Ames, Matthew Price
  • Phosphaplatin Liquid Formulations
    Publication number: 20200323810
    Abstract: Pharmaceutical compositions of phosphaplatin compounds, in particular buffered stable liquid formulations of pyrodach-2 ready for use in the treatment of various cancers, and methods of preparation are disclosed.
    Type: Application
    Filed: April 5, 2017
    Publication date: October 15, 2020
    Applicant: Phosplatin Therapeutics LLC
    Inventors: Wayne D. Luke, Tyler Ames
  • Phosphaplatin compounds as therapeutic agents for treatment of bone or blood cancers
    Patent number: 10668080
    Abstract: Use of (pyrophosphato)platinum(II) or (pyrophosphato)platinum(IV) complexes (“phosphaplatin compounds”), especially (R,R)-1,2-cyclohexanediamine-(dihydrogen pyrophosphato)platinum(II) (or “PT-112”), as therapeutic agents for treatment of bone and blood cancers, or cancers that metastasize to bones, and methods thereof, are disclosed.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: June 2, 2020
    Assignee: Phosplatin Therapeutics LLC
    Inventors: Matthew Price, Tyler Ames
  • PHOSPHAPLATIN COMPOUNDS AS THERAPEUTIC AGENTS FOR TREATMENT OF BONE OR BLOOD CANCERS
    Publication number: 20190328748
    Abstract: Use of (pyrophosphato)platinum(II) or (pyrophosphato)platinum(IV) complexes (“phosphaplatin compounds”), especially (R,R)1,2-cyclohexanediamine-(dihydrogen pyrophosphato)platinum(II) (or “PT-112”), as therapeutic agents for treatment of bone and blood cancers, or cancers that metastasize to bones, and methods thereof, are disclosed.
    Type: Application
    Filed: January 5, 2018
    Publication date: October 31, 2019
    Inventors: Matthew Price, Tyler Ames
  • Fluoride-responsive riboswitches, fluoride transporters, and methods of use
    Patent number: 9580713
    Abstract: Disclosed are compounds, compositions, and methods relating to fluoride aptamers, fluoride-responsive riboswitches, fluoride-regulated expression constructs, fluoride transporters, nucleic acids encoding fluoride transporters, expression constructs encoding fluoride transporters, and cells containing or including any combination of these.
    Type: Grant
    Filed: September 17, 2012
    Date of Patent: February 28, 2017
    Assignee: Yale University
    Inventors: Ronald Breaker, Jenny Baker, Narasimhan Sudarsan, Zasha Weinberg, Adam Roth, Tyler Ames, James Nelson
  • FLUORIDE-RESPONSIVE RIBOSWITCHS, FLUORIDE TRANSPORTERS, AND METHODS OF USE
    Publication number: 20150023889
    Abstract: Disclosed are compounds, compositions, and methods relating to fluoride aptamers, fluoride-responsive riboswitches, fluoride-regulated expression constructs, fluoride transporters, nucleic acids encoding fluoride transporters, expression constructs encoding fluoride transporters, and cells containing or including any combination of these.
    Type: Application
    Filed: September 17, 2012
    Publication date: January 22, 2015
    Inventors: Ronald Breaker, Jenny Baker, Narasimhan Sudarsan, Zasha Weinberg, Adam Roth, Tyler Ames, James Nelson
  • Purification of biochemically derived 1,3-propanediol
    Publication number: 20050277792
    Abstract: The invention discloses a hydrogenation process for removing impurities and controlling acid for use in downstream processing of biochemically-derived 1,3-propanediol. Preferably, the biochemically-derived 1,3-propanediol, before the contacting, has an initial color and, after the contracting, has a color that is lower than the initial color.
    Type: Application
    Filed: August 12, 2005
    Publication date: December 15, 2005
    Inventors: Mayis Seapan, George Diffendall, Robert Trotter, Tyler Ames, F. Gallagher
  • Purification of chemical 1,3-propanediol
    Publication number: 20050272962
    Abstract: Disclosed is a process comprising contacting chemical 1,3-propanediol with hydrogen in the presence of a hydrogenation catalyst. Preferably, the chemical 1,3-propanediol, before the contacting has an initial color and, after the contacting, has a color that is lower than the initial color.
    Type: Application
    Filed: August 12, 2005
    Publication date: December 8, 2005
    Inventors: Hari Sunkara, Mayis Seapan, George Diffendall, Tyler Ames
  • Purification of biologically-produced 1,3-propanediol
    Publication number: 20050069997
    Abstract: A process for purifying 1,3-propanediol from the fermentation broth of a cultured E. coli that has been bioengineered to synthesize 1,3-propanediol from sugar is provided. The basic process entails filtration, ion exchange and distillation of the fermentation broth product stream, preferably including chemical reduction of the product during the distillation procedure. Also provided are highly purified compositions of 1,3-propanediol.
    Type: Application
    Filed: May 5, 2004
    Publication date: March 31, 2005
    Inventors: Dennis Adkesson, Albert Alsop, Tyler Ames, Luis Chu, James Disney, Bryan Dravis, Patrick Fitzgibbon, James Gaddy, F. Gallagher, William Lehnhardt, Jefferson Lievense, Michael Luyben, Mayis Seapan, Robert Trotter, Gregory Wenndt, Eugene Yu