Abstract: A wide variety of scenarios are supported for per-biosample aggregation of sequencing yield. A sequencing system can sequence a plurality of biosamples in parallel. As sequencing yield results are acquired, they can be matched to biosamples and sequencing progress for the biosamples can be monitored. A target amount of yield can be specified so that a sequencing yield analysis application is automatically launched when aggregated yield reaches the target. Other features related to quality control and yield-in-progress can result in more efficient sequencing activities and reduction in waste.