Abstract: Provided herein are compositions or compounds comprising therapeutic proteins or peptides for treating metabolic diseases or disorders and/or for reducing weight in a subject in need thereof, and methods of using thereof.

Abstract: A delivery system includes an insertion device and an implant. The insertion device includes a body comprising a push button, a pusher wire, a backbone and a pushing mechanism. The pusher wire comprises a first end and a second end. The second end of the pusher wire is coupled to the pushing mechanism. The insertion device further includes an inserter tip comprising a needle. The inserter tip is configured to affix to the body. The implant is configured to be loaded into the insertion device. Upon depression of the push button, the pushing mechanism is activated and the pushing mechanism pushes the pusher wire into the implant and through the needle at a constant velocity and a predefined distance.

Abstract: Apparatuses, methods, and systems are disclosed for preparing CSI. One apparatus includes a processor and a memory with instructions executable by the processor to cause the apparatus to determine a total number of non-zero coefficients associated with a CSI codebook over a set of transmission layers and encode an indication of the total number of non-zero coefficients by selecting a codeword from a plurality of candidate codewords in which the selected codeword identifies the total number of non-zero coefficients. The instructions are executable by the processor to prepare CSI based on the CSI codebook and to transmit the CSI to a base station unit, where the CSI codebook includes a plurality of precoding matrices, and where the CSI includes the selected codeword.

Abstract: Provided herein are compounds having the structure of Formula Ia, wherein the compounds comprise a therapeutic agent having the sequence of SEQ ID NO: 35, and the compounds have an anion:cation molar ratio of from about 1:1 to about 1:7, and methods of using thereof for the treatment of metabolic diseases or disorders, including type 1 diabetes, type 2 diabetes, obesity, overweight, and nonalcoholic steatohepatitis, and for reducing weight in a subject in need thereof.

Abstract: Provided herein are compounds having the structure of Formula Ia, wherein the compounds comprise a therapeutic agent having the configuration of [diacid]-[linker]-[an amylin analog], in which the amylin analog has the amino acid sequence of SEQ ID NO: 20, with a proviso that the amino acid sequence comprises one or more of the following amino acid substitutions: N14E, V17R, Y37P, F15E, L16E, V17E, or any combination thereof, and the compounds have an anion: cation molar ratio of from about 1:1 to about 1:3, and methods of using thereof for the treatment of metabolic diseases or disorders, including type 1 diabetes, type 2 diabetes, obesity, overweight, and nonalcoholic steatohepatitis, and for reducing weight in a subject in need thereof.

Abstract: Provided herein are compounds having the structure of Formula I, wherein the compounds comprises a therapeutic agent having the sequence of SEQ ID NO: 35, and the compounds have an anion:cation molar ratio of from about 1:1 to about 1:7, and methods of using thereof for the treatment of metabolic diseases or disorders, including type 1 diabetes, type 2 diabetes, obesity, overweight, and nonalcoholic steatohepatitis, and for reducing weight in a subject in need thereof.

Abstract: The invention relates to recombinant viral vectors for the insertion and expression of foreign genes for use in safe immunizations to protect against a variety of pathogens. The invention also relates to multivalent compositions or vaccine comprising one or more recombinant viral vectors for protection against a variety of pathogens. The present invention relates to methods of making an using said recombinant viral vectors.

Abstract: The present disclosure relates to media compositions and/or supplements to be added into an organoid medium, and to methods for generating apical-out organoids. Apical-out organoids exhibit an apical surface thereof facing the external environment, and an inwardly disposed basolateral surface. Apical-out organoids may be formed in organoid media comprise a basal medium and one or more of an inhibitor of notch signaling and an inhibitor of signaling through a TGF. Apical-out organoids formed in accordance with the disclosed methods or in the disclosed media may be used to assay host responses to pathogens.

Abstract: Provided herein are compositions or compounds comprising ionic liquids and therapeutic proteins or peptides, and methods of use thereof for the treatment of diseases or disorders.

Abstract: Generating a channel state information (CSI) feedback report is provided. A set of reference signals is received. A plurality of entries that are included in the CSI feedback report are computed, where the entries of the CSI feedback report include at least a set of coefficients. Each coefficient is associated with a set of indices including at least one or more of a spatial domain basis index, a frequency domain basis index, and a layer index. The plurality of entries of the CSI feedback report are arranged in an order known to both the user equipment and the network entity. The plurality of entries of the CSI feedback report are prioritized using indices corresponding to the set of indices, where a subset of the set of indices are permuted based on predefined permutations of the subset of the set of indices.

Abstract: Provided herein are compositions or compounds comprising ionic liquids and therapeutic proteins or peptides, and methods of use thereof for the treatment of diseases or disorders.

Abstract: Provided herein are compositions or compounds comprising ionic liquids and therapeutic proteins or peptides, and methods of use thereof for the treatment of diseases or disorders.

Abstract: Provided herein are compositions or compounds comprising ionic liquids and therapeutic proteins or peptides, and methods of use thereof for the treatment of diseases or disorders.

Abstract: A system and method for generating recommendations of a vehicle corresponding to a driver's driving behavior includes receiving driving behavior data of the vehicle, receiving data related to ownership of the vehicle, receiving vehicle sales market data, generating an asset valuation, generating a recommendation to a user, and providing the recommendation to the user through a user device. The driving behavior data is generated from vehicle sensors and is received with one or more processors communicatively coupled to a vehicle. A trained machine-learning model is implemented by the one or more processors and generates an asset valuation. The trained machine-learning model generates a recommendation to a user based on the asset valuation and the driving behavior data. The recommendation includes a new or used vehicle for purchase or leasing. The recommendation is provided to a user though a user device.

Abstract: One apparatus for providing high-resolution CSI feedback includes a processor and a radio transceiver. The processor computes sets of amplitude and phase parameters for one or more matrices corresponding to a CSI codebook. Here, each matrix corresponds to one transmission layer of a multiple-layer transmission, where each matrix is comprised of one or more column vectors. The radio transceiver sends indications of the sets of amplitude and phase parameters to one or more network entities is a mobile communication network.

Abstract: Provided herein are compositions or compounds comprising ionic liquids and therapeutic proteins or peptides, and methods of use thereof for the treatment of diseases or disorders.

Abstract: According to a possible embodiment, a control channel can be received in a first downlink slot. The control channel can contain DCI with a downlink DCI format. The DCI can contain a CSI report trigger that triggers a CSI report. The DCI can schedule PDSCH transmissions repeated a number of times in a set of downlink slots. Each PDSCH transmission of the repeated PDSCH transmissions can be in a separate downlink slot. A CSI report can be generated in response to receiving the CSI report trigger. At least one uplink resource to transmit the generated CSI report can be determined. The at least one uplink resource can be determined based on the number of repeated PDSCH transmissions. The generated CSI report can be transmitted in the determined at least one uplink resource.

Abstract: Disclosed herein are ionic liquids and deep eutectic liquids for the treatment of diabetes and related diseases including obesity and metabolic disorders.

Abstract: Embodiments of the present disclosure include a method that accesses various portions of data related to an event in which a user was involved. The method further determines, for the event, which informatory elements related to the event meet at least a minimum significance threshold. The method next presents to the user, via a graphical user interface, one or more informational prompts associated with the event to obtain supporting information related to those informatory elements associated with the event that were determined to meet the minimum significance threshold. The method also generates a digital data structure that includes at least a portion of dynamically written language related to the event and further includes at least a portion of the supporting information received from the user in response to the informational prompts. Other corresponding systems and computer-readable media are provided.

Abstract: An ice making assembly includes an ice mold and a pump assembly for urging an ice-building spray into the ice mold to form an ice billet. A controller operates the pump assembly to provide the ice-building spray at a first flow rate until the ice billet reaches a predetermined thickness and then operates the pump assembly to provide the ice-building spray at a second flow rate that is less than the first flow rate.