Patents by Inventor Tyler Bywaters Rice
Tyler Bywaters Rice has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11800990Abstract: Methods and apparatus for measuring perfusion using transmission laser speckle imaging are provided. The apparatus comprises a coherent light source and a detector configured to measure transmitted light associated with an unfocused image at one or more locations. The coherent light source and detector are positioned in a transmission geometry. The apparatus further comprises means for securing the coherent light source and the detector to the tissue sample in a fixed transmission geometry relative to the tissue sample. The apparatus may further comprise at least one processor to receive information from the detector and process detected variations in transmitted light intensity to determine a single metric of perfusion. The method may comprise the steps transilluminating a tissue sample with coherent light, recording spatial and/or temporal variations in the transmitted light signal, determining speckle contrast value(s), and computing a metric of perfusion.Type: GrantFiled: December 21, 2017Date of Patent: October 31, 2023Assignee: Covidien AGInventors: Sean Michael White, Bruce Yee Yang, Tyler Bywaters Rice
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Patent number: 11759116Abstract: In some examples, a system includes processing circuitry configured to generate a laser speckle contrast signal based on a received signal indicative of detected light, wherein the detected light is scatted by tissue from a coherent light source. The processing circuitry may also determine, from the laser speckle contrast signal, a flow value and determine, from the laser speckle contrast signal, a waveform metric. Based on the flow value and the waveform metric, the processing circuitry may determine a blood flow metric for the tissue and output a representation of the blood flow metric.Type: GrantFiled: November 6, 2020Date of Patent: September 19, 2023Assignee: Covidien AGInventors: Sean Michael White, Bruce Yee Yang, Tyler Bywaters Rice
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Patent number: 11709120Abstract: Devices, systems, and methods are disclosed for improved laser speckle imaging of samples, such as vascularized tissue, for the determination of the rate of movement of light scattering particles within the sample. The system includes a structure adjoining a light source and a photo-sensitive detector. The structure can be positioned adjacent the sample (e.g., coupled to the sample) and configured to orient the light source and detector relative the sample such that surface reflections, including specular reflections and diffuse reflections, are discouraged from entering the detection field of the detector. The separation distance along the structure between the light source and the detector may further enable selective depth penetration into the sample and biased sampling of multiply scattered photons. The system includes an operably coupled processor programmed to derive contrast metrics from the detector and to relate the contrast metrics to a rate of movement of the light scattering particles.Type: GrantFiled: April 4, 2017Date of Patent: July 25, 2023Assignee: Covidien AGInventors: Tyler Bywaters Rice, Sean Michael White, Bruce Yee Yang
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Patent number: 11579004Abstract: Disclosed herein are systems, methods, and devices for calibrating contrast measurements from laser speckle imaging systems to accurately determine unknown particle motion characteristics, such as flow rate. The calibration stores to memory calibration data, which may include a set of measurements from samples with known particle characteristics and/or estimates of noise, including the effects on contrast arising from undesired signals unrelated to the unknown particle motion characteristics. The calibration data may be accessed and used to correct an empirical measurement of contrast and/or interpolate a value of the unknown particle motion characteristic. The system may include a light source, photodetector, processor, and memory, which can be combined into a single device, such as a wearable device, for providing calibrated flow measurements. The device may be used, for example, to measure blood flow, cardiac output, and heart rate, and can be used to amplify the pulsatile signal.Type: GrantFiled: March 22, 2021Date of Patent: February 14, 2023Assignee: COVIDIEN AGInventors: Tyler Bywaters Rice, Sean Michael White, Bruce Yee Yang
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Publication number: 20210293595Abstract: Disclosed herein are systems, methods, and devices for calibrating contrast measurements from laser speckle imaging systems to accurately determine unknown particle motion characteristics, such as flow rate. The calibration stores to memory calibration data, which may include a set of measurements from samples with known particle characteristics and/or estimates of noise, including the effects on contrast arising from undesired signals unrelated to the unknown particle motion characteristics. The calibration data may be accessed and used to correct an empirical measurement of contrast and/or interpolate a value of the unknown particle motion characteristic. The system may include a light source, photodetector, processor, and memory, which can be combined into a single device, such as a wearable device, for providing calibrated flow measurements. The device may be used, for example, to measure blood flow, cardiac output, and heart rate, and can be used to amplify the pulsatile signal.Type: ApplicationFiled: March 22, 2021Publication date: September 23, 2021Inventors: Tyler Bywaters Rice, Sean Michael White, Bruce Yee Yang
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Publication number: 20210177283Abstract: In some examples, a system includes processing circuitry configured to generate a laser speckle contrast signal based on a received signal indicative of detected light, wherein the detected light is scatted by tissue from a coherent light source. The processing circuitry may also determine, from the laser speckle contrast signal, a flow value and determine, from the laser speckle contrast signal, a waveform metric. Based on the flow value and the waveform metric, the processing circuitry may determine a blood flow metric for the tissue and output a representation of the blood flow metric.Type: ApplicationFiled: November 6, 2020Publication date: June 17, 2021Inventors: Sean Michael White, Bruce Yee Yang, Tyler Bywaters Rice
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Patent number: 10955275Abstract: Disclosed herein are systems, methods, and devices for calibrating contrast measurements from laser speckle imaging systems to accurately determine unknown particle motion characteristics, such as flow rate. The calibration stores to memory calibration data, which may include a set of measurements from samples with known particle characteristics and/or estimates of noise, including the effects on contrast arising from undesired signals unrelated to the unknown particle motion characteristics. The calibration data may be accessed and used to correct an empirical measurement of contrast and/or interpolate a value of the unknown particle motion characteristic. The system may include a light source, photodetector, processor, and memory, which can be combined into a single device, such as a wearable device, for providing calibrated flow measurements. The device may be used, for example, to measure blood flow, cardiac output, and heart rate, and can be used to amplify the pulsatile signal.Type: GrantFiled: April 18, 2017Date of Patent: March 23, 2021Assignee: Covidien LPInventors: Tyler Bywaters Rice, Sean Michael White, Bruce Yee Yang
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Publication number: 20210022623Abstract: Systems and methods are disclosed for determining physiological information in a subject. The system includes; a light source positionable along a first location outside of the subject; a photo-sensitive detector positionable along a second location outside of the subject and configured to detect scattered light and generate a signal; a processor having a program and a memory, wherein the processor is operably coupled to the detector and configured to receive and store the signals generated over a period of time; wherein the processor is programmed to derive contrast metrics from the stored signals, calculate a waveform from the contrast metrics, decompose the waveform into basis functions and respective amplitudes, and compare the basis function amplitudes to determine the physiological information.Type: ApplicationFiled: October 12, 2020Publication date: January 28, 2021Inventors: Tyler Bywaters Rice, Michael Ghijsen, Bruce J. Tromberg, Bruce Yee Yang, Sean Michael White
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Patent number: 10813597Abstract: Systems and methods are disclosed for determining physiological information in a subject. The system includes: a light source positionable along a first location outside of the subject; a photo-sensitive detector positionable along a second location outside of the subject and configured to detect scattered light and generate a signal; a processor having a program and a memory, wherein the processor is operably coupled to the detector and configured to receive and store the signals generated over a period of time; wherein the processor is programmed to derive contrast metrics from the stored signals, calculate a waveform from the contrast metrics, decompose the waveform into basis functions and respective amplitudes, and compare the basis function amplitudes to determine the physiological information.Type: GrantFiled: April 14, 2017Date of Patent: October 27, 2020Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, COVIDIEN LPInventors: Tyler Bywaters Rice, Michael Ghijsen, Bruce J. Tromberg, Bruce Yee Yang, Sean Michael White
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Publication number: 20200158548Abstract: Disclosed herein are systems, methods, and devices for calibrating contrast measurements from laser speckle imaging systems to accurately determine unknown particle motion characteristics, such as flow rate. The calibration stores to memory calibration data, which may include a set of measurements from samples with known particle characteristics and/or estimates of noise, including the effects on contrast arising from undesired signals unrelated to the unknown particle motion characteristics. The calibration data may be accessed and used to correct an empirical measurement of contrast and/or interpolate a value of the unknown particle motion characteristic. The system may include a light source, photodetector, processor, and memory, which can be combined into a single device, such as a wearable device, for providing calibrated flow measurements. The device may be used, for example, to measure blood flow, cardiac output, and heart rate, and can be used to amplify the pulsatile signal.Type: ApplicationFiled: April 18, 2017Publication date: May 21, 2020Inventors: Tyler Bywaters Rice, Sean Michael White, Bruce Yee Yang
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Publication number: 20190086316Abstract: Devices, systems, and methods are disclosed for improved laser speckle imaging of samples, such as vascularized tissue, for the determination of the rate of movement of light scattering particles within the sample. The system includes a structure adjoining a light source and a photo-sensitive detector. The structure can be positioned adjacent the sample (e.g., coupled to the sample) and configured to orient the light source and detector relative the sample such that surface reflections, including specular reflections and diffuse reflections, are discouraged from entering the detection field of the detector. The separation distance along the structure between the light source and the detector may further enable selective depth penetration into the sample and biased sampling of multiply scattered photons. The system includes an operably coupled processor programmed to derive contrast metrics from the detector and to relate the contrast metrics to a rate of movement of the light scattering particles.Type: ApplicationFiled: April 4, 2017Publication date: March 21, 2019Inventors: Tyler Bywaters Rice, Sean Michael White, Bruce Yee Yang
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Publication number: 20180296168Abstract: Systems and methods are disclosed for determining physiological information in a subject. The system includes: a light source positionable along a first location outside of the subject; a photo-sensitive detector positionable along a second location outside of the subject and configured to detect scattered light and generate a signal; a processor having a program and a memory, wherein the processor is operably coupled to the detector and configured to receive and store the signals generated over a period of time; wherein the processor is programmed to derive contrast metrics from the stored signals, calculate a waveform from the contrast metrics, decompose the waveform into basis functions and respective amplitudes, and compare the basis function amplitudes to determine the physiological information.Type: ApplicationFiled: April 14, 2017Publication date: October 18, 2018Inventors: Tyler Bywaters Rice, Michael Ghijsen, Bruce J. Tromberg, Bruce Yee Yang, Sean Michael White
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Publication number: 20180199829Abstract: Methods and apparatus for measuring perfusion using transmission laser speckle imaging are provided. The apparatus comprises a coherent light source and a detector configured to measure transmitted light associated with an unfocused image at one or more locations. The coherent light source and detector are positioned in a transmission geometry. The apparatus further comprises means for securing the coherent light source and the detector to the tissue sample in a fixed transmission geometry relative to the tissue sample. The apparatus may further comprise at least one processor to receive information from the detector and process detected variations in transmitted light intensity to determine a single metric of perfusion. The method may comprise the steps transilluminating a tissue sample with coherent light, recording spatial and/or temporal variations in the transmitted light signal, determining speckle contrast value(s), and computing a metric of perfusion.Type: ApplicationFiled: December 21, 2017Publication date: July 19, 2018Inventors: Sean Michael White, Bruce Yee Yang, Tyler Bywaters Rice
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Patent number: 9848787Abstract: Methods and apparatus for measuring perfusion using transmission laser speckle imaging are provided. The apparatus comprises a coherent light source and a detector configured to measure transmitted light associated with an unfocused image at one or more locations. The coherent light source and detector are positioned in a transmission geometry. The apparatus further comprises means for securing the coherent light source and the detector to the tissue sample in a fixed transmission geometry relative to the tissue sample. The apparatus may further comprise at least one processor to receive information from the detector and process detected variations in transmitted light intensity to determine a single metric of perfusion. The method may comprise the steps transilluminating a tissue sample with coherent light, recording spatial and/or temporal variations in the transmitted light signal, determining speckle contrast value(s), and computing a metric of perfusion.Type: GrantFiled: February 7, 2013Date of Patent: December 26, 2017Assignee: Laser Associated Sciences, Inc.Inventors: Sean Michael White, Bruce Yee Yang, Tyler Bywaters Rice
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Publication number: 20160166161Abstract: An apparatus for measuring vital signs and various states of health using the underlying concept of Photoplethysmography (PPG). This apparatus comprises one or more light source(s) and one or more detector(s) configured to measure transmitted and/or reflected light within the digits such as a finger or toe, but can also be applied to other soft tissue elements. The apparatus comprises a means to enhance signal quality, control the volume of interrogated tissue and minimize motion artifact. The apparatus comprises a power source. The apparatus may further comprise at least one processor to receive information from the detector and process measured variations in light intensity. This information may be transmitted wirelessly through technology such as Bluetooth. The apparatus may also comprise a system utilizing inductive charging (“wireless charging”).Type: ApplicationFiled: October 9, 2015Publication date: June 16, 2016Inventors: Bruce Yang, Tyler Bywaters Rice, Sean White
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Publication number: 20130204112Abstract: Methods and apparatus for measuring perfusion using transmission laser speckle imaging are provided. The apparatus comprises a coherent light source and a detector configured to measure transmitted light associated with an unfocused image at one or more locations. The coherent light source and detector are positioned in a transmission geometry. The apparatus further comprises means for securing the coherent light source and the detector to the tissue sample in a fixed transmission geometry relative to the tissue sample. The apparatus may further comprise at least one processor to receive information from the detector and process detected variations in transmitted light intensity to determine a single metric of perfusion. The method may comprise the steps transilluminating a tissue sample with coherent light, recording spatial and/or temporal variations in the transmitted light signal, determining speckle contrast value(s), and computing a metric of perfusion.Type: ApplicationFiled: February 7, 2013Publication date: August 8, 2013Applicant: Laser Associated Sciences, LLCInventors: Sean Michael White, Bruce Yee Yang, Tyler Bywaters Rice
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Patent number: D1009627Type: GrantFiled: December 17, 2021Date of Patent: January 2, 2024Inventors: Tyler Bywaters Rice, Ryan C. Wilson