Patents by Inventor Tyler Garretson

Tyler Garretson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Donor plasmid vectors
    Patent number: 11674157
    Abstract: Certain donor plasmid vectors such as pFastBac™1 and pFastBac™ Dual lack a cis DNA element upstream of the polh translation start codon (ATG) present in wild type (wt) Autographa californica multiple nucleopolyhedrovirus (AcMNPV), and contain a SV40 pA fragment. When a cis DNA element is inserted upstream of the 50 bp polh promoter and SV40 pA was replaced with a AcMNPV polh pA signal in pFastBac™1 and pFastBac™Dual, certain protein expression levels in High Five™ cells using the Bac-to-Bac® system reached that of the wt AcMNPV.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: June 13, 2023
    Assignee: Miami University
    Inventors: Xiao-Wen Cheng, Hui Shang, Tyler Garretson
  • DONOR PLASMID VECTORS
    Publication number: 20190002918
    Abstract: Certain donor plasmid vectors such as pFastBac™1 and pFastBac™ Dual lack a cis DNA element upstream of the polh translation start codon (ATG) present in wild type (wt) Autographa californica multiple nucleopolyhedrovirus (AcMNPV), and contain a SV40 pA fragment. When a cis DNA element is inserted upstream of the 50 bp polh promoter and SV40 pA was replaced with a AcMNPV polh pA signal in pFastBac™1 and pFastBac™Dual, certain protein expression levels in High Five™ cells using the Bac-to-Bac® system reached that of the wt AcMNPV.
    Type: Application
    Filed: June 19, 2018
    Publication date: January 3, 2019
    Inventors: Xiao-Wen Cheng, Hui Shang, Tyler Garretson
  • Recombinant baculovirus expression vector and cell
    Patent number: 9909106
    Abstract: A recombinant baculovirus expression vector or cell comprising an engineered baculovirus fp25k gene with one to three modified or mutated spots, the modified spots comprise the two 7-adenine mononucleotide repeats (MNR) and the 10th TTAA site. The invention also provides the method of making the vector and baculovirus.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: March 6, 2018
    Assignee: Miami University
    Inventors: Xiao-Wen Cheng, Xin-Hua Cheng, Tyler A. Garretson
  • Recombinant Baculovirus Expression Vector and Cell
    Publication number: 20160122724
    Abstract: A recombinant baculovirus expression vector or cell comprising an engineered baculovirus fp25k gene with one to three modified or mutated spots, the modified spots comprise the two 7-adenine mononucleotide repeats (MNR) and the 10th TTAA site. The invention also provides the method of making the vector and baculovirus.
    Type: Application
    Filed: February 14, 2014
    Publication date: May 5, 2016
    Inventors: Xiao-Wen Cheng, Xin-Hua Cheng, Tyler A. Garretson