Patents by Inventor Tyler Grove

Tyler Grove has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AND METHODS FOR TREATMENT OF BACTERIAL INFECTIONS
    Publication number: 20250197344
    Abstract: This document discloses a novel class of compounds for inhibiting bacterial growth and treating bacterial infection. The compounds target a key step of the futalosine pathway and therefore are effective for the selective inhibition of certain bacterial species and genera with reduced side effect in comparison with conventional antibiotics.
    Type: Application
    Filed: March 7, 2025
    Publication date: June 19, 2025
    Inventors: Steven C. Almo, Tyler Grove, Lawrence D. Harris, Gary B. Evans
  • Compounds and methods for treatment of bacterial infections
    Patent number: 12258304
    Abstract: This document discloses a novel class of compounds for inhibiting bacterial growth and treating bacterial infection. The compounds target a key step of the futalosine pathway and therefore are effective for the selective inhibition of certain bacterial species and genera with reduced side effect in comparison with conventional antibiotics.
    Type: Grant
    Filed: May 20, 2020
    Date of Patent: March 25, 2025
    Assignees: Albert Einstein College of Medicine, Victoria Link Limited
    Inventors: Steven C. Almo, Tyler Grove, Lawrence D. Harris, Gary B. Evans
  • ANTIVIRAL NUCLEOSIDE ANALOGUES
    Publication number: 20240287123
    Abstract: Compounds of the Formula (I), pharmaceutical compositions comprising compounds of the Formula (I), and their use for treating or preventing an infection caused by Human Cytomegalovirus (HCMV), Epstein-Barr virus (EBV), or Human Immunodeficiency Virus (HIV):
    Type: Application
    Filed: May 31, 2022
    Publication date: August 29, 2024
    Inventors: Steven C. Almo, Tyler Grove, Gary Brian Evans, Lawrence Daniel Harris, Rinu Shrestha, James Michael Wood
  • BIOTIN SYNTHASES FOR EFFICIENT PRODUCTION OF BIOTIN
    Publication number: 20220348974
    Abstract: A recombinant microorganism includes a transgene encoding a polypeptide of a Type II biotin synthase, wherein a holo-protein of the Type II biotin synthase comprises per polypeptide chain a first [4Fe—4S] cluster (radical SAM (RS) cluster) coordinated to a CxxxCxxC motif in the polypeptide chain and a second [4Fe—4S] cluster. The Type II biotin synthase contains a serine to cysteine swap in its holo-protein amino acid sequence, that is the amino acid at the position corresponding to Ser-43 in the E. coli K12 Type I biotin synthase holo-protein is a Cysteine and the amino acid corresponding to Cys-97 in the E. coli K12 Type I biotin synthase holo-protein is a Serine. A method for producing biotin includes cultivating the recombinant microorganism in a growth medium to produce a culture; and recovering biotin from the culture.
    Type: Application
    Filed: September 4, 2020
    Publication date: November 3, 2022
    Inventors: Steven C. ALMO, Tyler GROVE
  • COMPOUNDS AND METHODS FOR TREATMENT OF BACTERIAL INFECTIONS
    Publication number: 20220234995
    Abstract: This document discloses a novel class of compounds for inhibiting bacterial growth and treating bacterial infection. The compounds target a key step of the futalosine pathway and therefore are effective for the selective inhibition of certain bacterial species and genera with reduced side effect in comparison with conventional antibiotics.
    Type: Application
    Filed: May 20, 2020
    Publication date: July 28, 2022
    Applicants: Albert Einstein College of Medicine, Victoria Link Limited
    Inventors: Steven C. Almo, Tyler Grove, Lawrence D. Harris, Gary B. Evans
  • Broad spectrum viral inhibitor
    Patent number: 11279728
    Abstract: Compounds and methods for treating viral infections and reducing viral multiplication, including flaviviruses. Provided is a derivative of a compound or a pharmaceutical salt thereof, wherein the compound comprises a 3?,4-didehydroribose.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: March 22, 2022
    Assignees: Albert Einstein College of Medicine, The Penn State Research Foundation
    Inventors: Steven C. Almo, Tyler Grove, Anthony Gizzi, Craig E. Cameron, James J. Arnold
  • BROAD SPECTRUM VIRAL INHIBITOR
    Publication number: 20200361982
    Abstract: Compounds and methods for treating viral infections and reducing viral multiplication, including flaviviruses. Provided is a derivative of a compound or a pharmaceutical salt thereof, wherein the compound comprises a 3?,4-didehydroribose.
    Type: Application
    Filed: August 21, 2018
    Publication date: November 19, 2020
    Inventors: Steven C. Almo, Tyler Grove, Anthony Gizzi, Craig E. Cameron, James J. Arnold