Patents by Inventor Tyler Lahusen

Tyler Lahusen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for the activation of gamma-delta T-cells
    Patent number: 10772905
    Abstract: The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular, can be used in the treatment of various cancers and infectious diseases.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: September 15, 2020
    Assignee: American Gene Technologies International Inc.
    Inventors: Charles David Pauza, Haishan Li, Tyler Lahusen, Mei-Ling Liou
  • Combination vectors and methods for treating cancer
    Patent number: 10767183
    Abstract: A composition for treating cancer is disclosed. The composition includes a lentiviral particle and an aminobisphosphonate drug. The lentiviral particle is capable of infecting a target cell, such as a cancer cell, and includes an envelope protein optimized for targeting such target cell and a viral vector. The viral vector includes a small RNA optimized to target an FDPS mRNA sequence. The aminobisphosphonate drug includes zoledronic acid.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: September 8, 2020
    Assignee: American Gene Technologies International Inc.
    Inventors: Tyler Lahusen, Mei-Ling Liou, Lingzhi Xiao, Haishan Li, Charles David Pauza
  • METHODS AND COMPOSITIONS FOR THE ACTIVATION OF TUMOR CYTOTOXICITY VIA HUMAN GAMMA-DELTA T-CELLS
    Publication number: 20200181645
    Abstract: The present disclosure relates generally to methods and compositions for activating gamma-delta (GD) T cells. Such methods and compositions can be used to treat cancer.
    Type: Application
    Filed: June 15, 2018
    Publication date: June 11, 2020
    Inventors: Charles David Pauza, Tyler Lahusen, Haishan Li, Mei-Ling Liou, Lingzhi Xiao
  • HIV PRE-IMMUNIZATION AND IMMUNOTHERAPY
    Publication number: 20200109417
    Abstract: The present invention relates generally to immunization and immunotherapy for the treatment or prevention of HIV. In particular, the methods include in vivo and/or ex vivo enrichment of HIV-specific CD4+ T cells.
    Type: Application
    Filed: October 4, 2019
    Publication date: April 9, 2020
    Inventors: Charles David Pauza, Haishan Li, Tyler Lahusen, Jeff Galvin
  • COMPOSITIONS AND METHODS FOR TREATING PHENYLKETONURIA
    Publication number: 20200087682
    Abstract: A lentiviral vector system for expressing a lentiviral particle is disclosed. The lentiviral vector system includes a therapeutic vector. The therapeutic vector comprises a phenylalanine hydroxylase (PAH) sequence for expressing at least one of PAH or a variant thereof, wherein the PAH sequence is truncated.
    Type: Application
    Filed: April 2, 2018
    Publication date: March 19, 2020
    Inventors: Tyler Lahusen, Charles David Pauza
  • METHODS AND COMPOSITIONS FOR THE ACTIVATION OF GAMMA-DELTA T-CELLS
    Publication number: 20200063161
    Abstract: The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular, can be used in the treatment of various cancers and infectious diseases.
    Type: Application
    Filed: September 6, 2019
    Publication date: February 27, 2020
    Inventors: Charles David Pauza, Haishan Li, Tyler Lahusen, Mei-Ling Liou
  • METHODS AND COMPOSITIONS FOR THE ACTIVATION OF GAMMA-DELTA T-CELLS
    Publication number: 20190388456
    Abstract: The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular, can be used in the treatment of various cancers and infectious diseases.
    Type: Application
    Filed: August 2, 2019
    Publication date: December 26, 2019
    Inventors: Charles David Pauza, Haishan Li, Tyler Lahusen, Mei-Ling Liou
  • HIV pre-immunization and immunotherapy
    Patent number: 10494647
    Abstract: The present invention relates generally to immunization and immunotherapy for the treatment or prevention of HIV. In particular, the methods include in vivo and/or ex vivo enrichment of HIV-specific CD4+ T cells.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: December 3, 2019
    Assignee: American Gene Technologies International Inc.
    Inventors: Charles David Pauza, Haishan Li, Tyler Lahusen, Jeff Galvin
  • Methods and compositions for the activation of gamma-delta T-cells
    Patent number: 10472649
    Abstract: The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular, can be used in the treatment of various cancers and infectious diseases.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: November 12, 2019
    Assignee: American Gene Technologies International Inc.
    Inventors: Charles David Pauza, Haishan Li, Tyler Lahusen, Mei-Ling Liou
  • Methods and compositions for the activation of gamma-delta T-cells
    Patent number: 10428350
    Abstract: The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular, can be used in the treatment of various cancers and infectious diseases.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: October 1, 2019
    Assignee: American Gene Technologies International Inc.
    Inventors: Charles David Pauza, Haishan Li, Tyler Lahusen, Mei-Ling Liou
  • Methods and compositions for the activation of gamma-delta T-cells
    Patent number: 10420789
    Abstract: The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular, can be used in the treatment of various cancers and infectious diseases.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: September 24, 2019
    Assignee: American Gene Technologies International Inc.
    Inventors: Charles David Pauza, Haishan Li, Tyler Lahusen, Mei-Ling Liou
  • VIRAL VECTORS FOR TREATING PARKINSON'S DISEASE
    Publication number: 20190282639
    Abstract: A lentiviral vector system for expressing a lentiviral particle is disclosed. The lentiviral vector system includes a therapeutic vector, an envelope plasmid, and at least one helper plasmid. The lentiviral vector system can produce a lentiviral particle for inhibiting PARP expression in neuron cells of a subject afflicted with Parkinson's disease.
    Type: Application
    Filed: July 20, 2017
    Publication date: September 19, 2019
    Inventors: Tyler Lahusen, Charles David Pauza
  • NON-INTEGRATING VIRAL DELIVERY SYSTEM AND METHODS RELATED THERETO
    Publication number: 20190264226
    Abstract: A non-integrating viral delivery system is disclosed. The system includes a viral carrier, wherein the viral carrier contains a defective integrase gene; a heterologous viral episomal origin of replication; a sequence encoding at least one initiator protein specific for the heterologous viral episomal origin of replication, wherein expression of the sequence encoding the at least one initiator protein specific for the heterologous viral episomal origin of DNA replication is inducible; and at least one gene, gene product, shRNA, siRNA, miRNA, or other RNA of interest.
    Type: Application
    Filed: December 12, 2016
    Publication date: August 29, 2019
    Inventors: Charles David Pauza, Tyler Lahusen
  • NON-INTEGRATING VIRAL DELIVERY SYSTEM AND METHODS RELATED THERETO
    Publication number: 20190255190
    Abstract: A non-integrating viral delivery system is disclosed. The system includes a viral carrier, wherein the viral carrier contains a defective integrase gene; a heterologous viral episomal origin of replication; a sequence encoding at least one initiator protein specific for the heterologous viral episomal origin of replication, wherein expression of the sequence encoding the at least one initiator protein specific for the heterologous viral episomal origin of DNA replication is inducible; and at least one gene, gene product, shRNA, siRNA, miRNA, or other RNA of interest.
    Type: Application
    Filed: June 7, 2017
    Publication date: August 22, 2019
    Inventors: Charles David Pauza, Tyler Lahusen
  • HIV PRE-IMMUNIZATION AND IMMUNOTHERAPY
    Publication number: 20190218573
    Abstract: The present invention relates generally to immunization and immunotherapy for the treatment or prevention of HIV. In particular, the methods include in vivo and/or ex vivo enrichment of HIV-specific CD4+ T cells.
    Type: Application
    Filed: December 12, 2018
    Publication date: July 18, 2019
    Inventors: Charles David Pauza, Haishan Li, Tyler Lahusen, Jeff Galvin
  • HIV PRE-IMMUNIZATION AND IMMUNOTHERAPY
    Publication number: 20190201523
    Abstract: The present invention relates generally to immunization and immunotherapy for the treatment or prevention of HIV. In particular, the methods include in vivo and/or ex vivo enrichment of HIV-specific CD4+ T cells.
    Type: Application
    Filed: July 7, 2017
    Publication date: July 4, 2019
    Inventors: Charles David Pauza, Haishan Li, Tyler Lahusen, Gary Mansfield
  • METHODS AND COMPOSITIONS FOR THE ACTIVATION OF GAMMA-DELTA T-CELLS
    Publication number: 20190083523
    Abstract: The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular, can be used in the treatment of various cancers and infectious diseases.
    Type: Application
    Filed: September 14, 2018
    Publication date: March 21, 2019
    Inventors: Charles David Pauza, Haishan Li, Tyler Lahusen, Mei-Ling Liou
  • HIV pre-immunization and immunotherapy
    Patent number: 10233464
    Abstract: The present invention relates generally to immunization and immunotherapy for the treatment or prevention of HIV. In particular, the methods include in vivo and/or ex vivo enrichment of HIV-specific CD4+ T cells.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: March 19, 2019
    Assignee: American Gene Technologies International Inc.
    Inventors: Charles David Pauza, Haishan Li, Tyler Lahusen, Jeff Galvin
  • COMBINATION VECTORS AND METHODS FOR TREATING CANCER
    Publication number: 20190078096
    Abstract: A composition for treating cancer is disclosed. The composition includes a lentiviral particle and an aminobisphosphonate drug. The lentiviral particle is capable of infecting a target cell, such as a cancer cell, and includes an envelope protein optimized for targeting such target cell and a viral vector. The viral vector includes a small RNA optimized to target an FDPS mRNA sequence. The aminobisphosphonate drug includes zoledronic acid.
    Type: Application
    Filed: March 9, 2017
    Publication date: March 14, 2019
    Inventors: Tyler Lahusen, Mei-Ling Liou, Lingzhi Xiao, Haishan Li, Charles David Pauza
  • METHODS AND COMPOSITIONS FOR THE ACTIVATION OF GAMMA-DELTA T-CELLS
    Publication number: 20190062786
    Abstract: The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular, can be used in the treatment of various cancers and infectious diseases.
    Type: Application
    Filed: November 6, 2018
    Publication date: February 28, 2019
    Inventors: Charles David Pauza, Haishan Li, Tyler Lahusen, Mei-Ling Liou