Patents by Inventor Tyler Picariello

Tyler Picariello has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MUSCLE TARGETING COMPLEXES AND USES THEREOF FOR TREATING MYOTONIC DYSTROPHY
    Publication number: 20240325558
    Abstract: The present application relates to oligonucleotides (e.g., antisense oligonucleotides such as gapmers) designed to target DMPK RNAs and targeting complexes for delivering the oligonucleotides to cells (e.g., muscle cells) and uses thereof, particularly uses relating to treatment of disease. In some embodiments, the muscle-targeting agent specifically binds to an internalizing cell surface receptor on muscle cells. In some embodiments, the molecular payload inhibits expression or activity of DMPK.
    Type: Application
    Filed: July 8, 2022
    Publication date: October 3, 2024
    Applicant: Dyne Therapeutics, Inc.
    Inventors: Stefano Zanotti, Tyler Picariello, Timothy Weeden, Cody A. Desjardins, Romesh R. Subramanian, Mohammed T. Qatanani, Brendan Quinn, John Najim