Abstract: The invention provides a method of investigating the spatial organisation of proteins in or on cells, and the use of that spatial organisation information to inform decisions about medical interventions, especially in relation to cancer treatments including CAR-T therapy. The method involves detecting one or more species of proteins on each of the plurality of cells; obtaining respective spatial coordinates of the detected proteins within the plurality of cells; detecting boundaries of the plurality of cells; and constructing a data vector based on the obtained spatial coordinates and the detected boundaries.

Abstract: Apparatus and methods are described that include ultrasound imaging devices, which may operate in a transmissive ultrasound imaging modality, and which may be used to detect properties of interest of a subject such as index of refraction, density and/or speed of sound. Devices suitable for performing high intensity focused ultrasound (HIFU), as well as HIFU and ultrasound imaging, are also described.

Abstract: Apparatus and methods are described that include ultrasound imaging devices, which may operate in a transmissive ultrasound imaging modality, and which may be used to detect properties of interest of a subject such as index of refraction, density and/or speed of sound. Devices suitable for performing high intensity focused ultrasound (HIFU), as well as HIFU and ultrasound imaging, are also described.