Patents by Inventor Tyler S. Klann

Tyler S. Klann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYSTEMS AND METHODS FOR GENOME-WIDE ANNOTATION OF GENE REGULATORY ELEMENTS LINKED TO CELL FITNESS
    Publication number: 20240058425
    Abstract: Disclosed herein are compositions and methods for targeting a novel regulatory element of a gene. The compositions may be used in methods of modifying growth of a cell, decreasing cell fitness, increasing cell fitness, and/or treating cancer such as leukemia.
    Type: Application
    Filed: March 8, 2023
    Publication date: February 22, 2024
    Inventors: Charles A. Gersbach, Alejandro Barrera, Tyler S. Klann, Maria ter Weele, Gregory E. Crawford, Timothy E. Reddy
  • High-throughput screening of regulatory element function with epigenome editing technologies
    Patent number: 10676735
    Abstract: Disclosed herein are methods of using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) 9-based epigenomic editing systems for high-throughput screening of regulatory element function.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: June 9, 2020
    Assignee: Duke University
    Inventors: Charles A. Gersbach, Gregory E. Crawford, Timothy E. Reddy, Tyler S. Klann
  • HIGH-THROUGHPUT SCREENING OF REGULATORY ELEMENT FUNCTION WITH EPIGENOME EDITING TECHNOLOGIES
    Publication number: 20180291370
    Abstract: Disclosed herein are methods of using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) 9-based epigenomic editing systems for high-throughput screening of regulatory element function.
    Type: Application
    Filed: July 22, 2016
    Publication date: October 11, 2018
    Inventors: Charles A. Gersbach, Gregory E. Crawford, Timothy E. Reddy, Tyler S. Klann