Abstract: A method, system, and computer program product are disclosed for performance monitoring of a smart fluid injector system having at least one sensor configured for detecting operation data. The operation data includes one or more operation parameters associated with at least one of: one or more drive components of the fluid injector system and at least one disposable component configured for use with the fluid injector system. The fluid injector system further includes a control device having at least one processor programmed or configured to: receive the operation data, and determine a component status for at least one of: the drive component(s), the disposable component(s), and administration line(s) by comparing the received operation data with stored operation data. The component status includes one or more predictions of an operation failure or a misuse of at least one of: the drive component(s), the disposable component(s), and administration line(s).