Patents by Inventor Tyrone Chad Otgaar

Tyrone Chad Otgaar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds for use in the treatment of telomere related diseases and/or telomere related medical conditions
    Patent number: 11896645
    Abstract: The invention relates to compounds for use in the treatment of telomere related diseases and/or telomere related medical conditions, particularly wherein said telomere related diseases and/or telomere related medical conditions are cancer and cellular ageing. Particularly, herein is disclosed 37 kDa/67 kDa laminin receptor precursor/high affinity laminin receptor (LRP/LR) and/or a fragment thereof for use in the treatment and/or prevention of cellular ageing.
    Type: Grant
    Filed: February 17, 2021
    Date of Patent: February 13, 2024
    Assignee: UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG
    Inventors: Stefan Franz Thomas Weiss, Boitelo Theresiah Letsolo, Kerrilyn Naidoo, Tyrone Chad Otgaar
  • A METHOD OF DECREASING CONCENTRATION OF TAU (T) PROTEIN AND/OR PHOSPHORYLATED TAU (T) PROTEIN
    Publication number: 20230212250
    Abstract: This disclosure relates to a method of decreasing concentration of tau (?) protein and/or phosphorylated tau (?) protein in a target cell of a human or animal subject having Alzheimer's Disease (AD). The disclosure extends to use of biopharmaceutical agents including (i). 37 kDa/67 kDa laminin receptor precursor/high affinity laminin receptor (LRP/LR) and/or a fragment thereof, or (ii). a transfecting agent for the expression of LRP/LR, for use in treating Alzheimer's Disease (AD).
    Type: Application
    Filed: May 11, 2020
    Publication date: July 6, 2023
    Applicant: UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG
    Inventors: Stefan Franz Thomas WEISS, Katelyn CUTTLER, Tyrone Chad OTGAAR, Eloise VAN DER MERWE, Monique J. BIGNOUX
  • BIOPHARMACEUTICAL AGENTS FOR USE IN REDUCING LIPID CONTENT IN CELLS
    Publication number: 20210277084
    Abstract: A biopharmaceutical agent including a 37 kDa/67 kDa laminin receptor precursor/high affinity laminin receptor (LRP/LR) and/or a fragment thereof for use in treatment and/or prevention of atherosclerosis and/or obesity and/or insulin resistance and/or diabetes. The biopharmaceutical agent may be encapsulated by functionalized or non-functionalized nanoparticles, and further may be formulated to include a carrier to provide a pharmaceutical composition for parental or non-parental administration. In use, the biopharmaceutical agent reduces lipid content in target cells. Also, a method of decreasing lipid concentration in a target cell of a human or animal subject.
    Type: Application
    Filed: July 8, 2019
    Publication date: September 9, 2021
    Applicant: UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG
    Inventors: Stefan Franz Thomas WEISS, Tyrone Chad OTGAAR, Eloise VAN DER MERWE, Martin BERNERT, Gavin MORRIS
  • COMPOUNDS FOR USE IN THE TREATMENT OF TELOMERE RELATED DISEASES AND/OR TELOMERE RELATED MEDICAL CONDITIONS
    Publication number: 20210169974
    Abstract: The invention relates to compounds for use in the treatment of telomere related diseases and/or telomere related medical conditions, particularly wherein said telomere related diseases and/or telomere related medical conditions are cancer and cellular ageing. Particularly, herein is disclosed 37 kDa/67 kDa laminin receptor precursor/high affinity laminin receptor (LRP/LR) and/or a fragment thereof for use in the treatment and/or prevention of cellular ageing.
    Type: Application
    Filed: February 17, 2021
    Publication date: June 10, 2021
    Inventors: Stefan Franz Thomas Weiss, Boitelo Theresiah Letsolo, Kerrilyn Naidoo, Tyrone Chad Otgaar
  • COMPOUNDS FOR USE IN THE TREATMENT OF TELOMERE RELATED DISEASES AND/OR TELOMERE RELATED MEDICAL CONDITIONS
    Publication number: 20180325997
    Abstract: The invention relates to compounds for use in the treatment of telomere related diseases and/or telomere related medical conditions, particularly wherein said telomere related diseases and/or telomere related medical conditions are cancer and cellular ageing. Particularly, herein is disclosed 37 kDa/67 kDa laminin receptor precursor/high affinity laminin receptor (LRP/LR) and/or a fragment thereof for use in the treatment and/or prevention of cellular ageing.
    Type: Application
    Filed: November 7, 2016
    Publication date: November 15, 2018
    Inventors: Stefan Franz Thomas Weiss, Boitelo Theresiah Letsolo, Kerrilyn Naidoo, Tyrone Chad Otgaar