Abstract: Methods, systems and adaptors for multiphoton imaging of, and laser-tissue interactions with, non-transparent tissue, such as ocular and periocular tissue, are provided. Aspects of the present invention include methods of imaging a structure through non-transparent tissue, such as ocular or periocular tissue, comprising: deploying an excitation source to transmit light energy to a structure through non-transparent tissue, such as ocular or periocular tissue, detecting light emitted from the structure via multiphoton excitation through the non-transparent tissue, such as ocular or periocular tissue, and imaging the structure based on the detected light.

Abstract: An ophthalmoscope for viewing an eye of a patient, including an optical device with a housing having a bottom window, a rear window, and a front wall including a reflective inner surface. A top wall may include a first portion, and a second portion wherein the first portion includes a reflective inner surface. A pair of side walls extends between side edges of the bottom window, the rear window, the top wall, and the front wall. The reflective inner surfaces of the top wall and the front wall are configured to direct light rays that enter the bottom window from the eye of the patient out of the rear window into the eyes of the ophthalmologist.