Patents by Inventor Tza-Huei J. Wang

Tza-Huei J. Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • System and method for screening a library of samples
    Patent number: 10739366
    Abstract: A continuous throughput microfluidic system includes an input system configured to provide a sequential stream of sample plugs; a droplet generator arranged in fluid connection with the input system to receive the sequential stream of sample plugs and configured to provide an output stream of droplets; a droplet treatment system arranged in fluid connection with the droplet generator to receive the output stream of droplets in a sequential order and configured to provide a stream of treated droplets in the sequential order; a detection system arranged to obtain detection signals from the treated droplets in the sequential order; a control system configured to communicate with the input system, the droplet generator, and the droplet treatment system; and a data processing and storage system configured to communicate with the control system and the detection system.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: August 11, 2020
    Assignee: The Johns Hopkins University
    Inventors: Tza-huei J. Wang, Tushar Dnyandeo Rane, Helena Claire Zec, Wen-Chy Chu
  • SYSTEM AND METHOD FOR SCREENING A LIBRARY OF SAMPLES
    Publication number: 20190154715
    Abstract: A continuous throughput microfluidic system includes an input system configured to provide a sequential stream of sample plugs; a droplet generator arranged in fluid connection with the input system to receive the sequential stream of sample plugs and configured to provide an output stream of droplets; a droplet treatment system arranged in fluid connection with the droplet generator to receive the output stream of droplets in a sequential order and configured to provide a stream of treated droplets in the sequential order; a detection system arranged to obtain detection signals from the treated droplets in the sequential order; a control system configured to communicate with the input system, the droplet generator, and the droplet treatment system; and a data processing and storage system configured to communicate with the control system and the detection system.
    Type: Application
    Filed: January 18, 2019
    Publication date: May 23, 2019
    Applicants: The Johns Hopkins University, Pioneer Hi-Bred International, Inc.
    Inventors: Tza-huei J. Wang, Tushar Dnyandeo Rane, Helena Claire Zec, Wen-Chy Chu
  • System and method for screening a library of samples
    Patent number: 10222392
    Abstract: A continuous throughput microfluidic system includes an input system configured to provide a sequential stream of sample plugs; a droplet generator arranged in fluid connection with the input system to receive the sequential stream of sample plugs and configured to provide an output stream of droplets; a droplet treatment system arranged in fluid connection with the droplet generator to receive the output stream of droplets in a sequential order and configured to provide a stream of treated droplets in the sequential order; a detection system arranged to obtain detection signals from the treated droplets in the sequential order; a control system configured to communicate with the input system, the droplet generator, and the droplet treatment system; and a data processing and storage system configured to communicate with the control system and the detection system.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: March 5, 2019
    Assignees: The Johns Hopkins University, Pioneer Hi-Bred International, Inc.
    Inventors: Tza-huei J. Wang, Tushar Dnyandeo Rane, Helena Claire Zec, Wen-Chy Chu
  • Multiplexed, continuous-flow, droplet-based platform for high-throughput genetic detection
    Patent number: 10041112
    Abstract: The present application relates to a continuous droplet flow microfluidic system, including a microfluidic chip including an optical detection section; a stage assembly including a microfluidic chip holder configured to receive the microfluidic chip and a plurality of heating elements arranged to heat a plurality of separate sections of the microfluidic chip to a corresponding plurality of different temperatures; and an optical detection system arranged to detect fluorescent light emitted from said optical detection section of the microfluidic chip.
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: August 7, 2018
    Assignees: The Johns Hopkins University, Pioneer Hi-Bred International, Inc.
    Inventors: Tza-Huei J. Wang, Kuangwen Hsieh, Helena C. Zec, Lingshu Liu, Aniruddha M. Kaushik, Yue Yun
  • MULTIPLEXED, CONTINUOUS-FLOW, DROPLET-BASED PLATFORM FOR HIGH-THROUGHPUT GENETIC DETECTION
    Publication number: 20160298173
    Abstract: The present application relates to a continuous droplet flow microfluidic system, including a microfluidic chip including an optical detection section; a stage assembly including a microfluidic chip holder configured to receive the microfluidic chip and a plurality of heating elements arranged to heat a plurality of separate sections of the microfluidic chip to a corresponding plurality of different temperatures; and an optical detection system arranged to detect fluorescent light emitted from said optical detection section of the microfluidic chip.
    Type: Application
    Filed: April 13, 2016
    Publication date: October 13, 2016
    Applicants: The Johns Hopkins University, Pioneer Hi-Bred International, Inc.
    Inventors: Tza-Huei J. Wang, Kuangwen Hsieh, Helena C. Zee, Lingshu Liu, Aniruddha M. Kaushik, Yue Yun