Patents by Inventor Tzong-Yuan Wu
Tzong-Yuan Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220196673Abstract: Disclosed herein are recombinant baculoviruses suitable for detecting the presence of arthropod-borne viruses in a biological sample of a test subject. The information derived from the detection may also be used to render a diagnosis on whether the test subject is infected with the arthropod-borne viruses or not, so that proper course of treatment may be assigned to the subject.Type: ApplicationFiled: March 9, 2022Publication date: June 23, 2022Applicant: Chung Yuan Christian UniversityInventors: Tzong-Yuan WU, Szu-Cheng KUO, Pei-Yun SHU, Chang-Chi LIN, Der-Jiang CHIAO, Ying-Ju CHEN, Yi-Ting LIN, Shu-Fen CHANG, Chien-Ling SU
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Publication number: 20220111032Abstract: The present invention is directed to novel immunogenic compositions that protect swine from disease caused by porcine epidemic diarrhea virus (PEDV). The compositions of the invention provide virus-like particles (VLPs) whose effectiveness is enhanced by the selection of preferred adjuvants.Type: ApplicationFiled: October 8, 2020Publication date: April 14, 2022Applicants: Chung Yuan Christian University, Academia SinicaInventors: Tzong-Yuan WU, Ming-Hao CHANG, Hui-Wen CHANG, Yu-Chan CHAO, Wei-Ting HSU
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Publication number: 20200300856Abstract: Disclosed herein are recombinant baculoviruses suitable for detecting the presence of arthropod-borne viruses in a biological sample of a test subject. The information derived from the detection may also be used to render a diagnosis on whether the test subject is infected with the arthropod-borne viruses or not, so that proper course of treatment may be assigned to the subject.Type: ApplicationFiled: June 4, 2020Publication date: September 24, 2020Applicant: Chung Yuan Christian UniversityInventors: Tzong-Yuan WU, Szu-Cheng KUO, Pei-Yun SHU, Chang-Chi LIN, Der-Jiang CHIAO, Ying-Ju CHEN, Yi-Ting LIN, Shu-Fen CHANG, Chien-Ling SU
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Patent number: 10718771Abstract: Disclosed herein are recombinant baculoviruses suitable for detecting the presence of arthropod-borne viruses in a biological sample of a test subject. The information derived from the detection may also be used to render a diagnosis on whether the test subject is infected with the arthropod-borne viruses or not, so that proper course of treatment may be assigned to the subject.Type: GrantFiled: February 9, 2018Date of Patent: July 21, 2020Assignee: Chung Yuan Christian UniversityInventors: Tzong-Yuan Wu, Szu-Cheng Kuo, Pei-Yun Shu, Chang-Chi Lin, Der-Jiang Chiao, Ying-Ju Chen, Yi-Ting Lin, Shu-Fen Chang, Chien-Ling Su
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Publication number: 20190365852Abstract: Disclosed herein are recombinant baculoviruses suitable for introducing an exogenous gene into a pest insect, particularly, disease-transmitting mosquitos. The recombinant baculovirus is characterized in having a promotor that is any of a HzNV-1 viral early expressing gene pag1, a ceropin gene b1, a defensin gene a4, or hp70 gene; and an exogenous gene operably linked thereto the promoter. Also disclosed herein is a method of introducing an exogenous gene into a pest insect. The method includes transducing the pest insect with a recombinant baculovirus without suppressing the production of microRNAs (miRNAs) in the pest insect, wherein the recombinant baculovirus comprises a promoter of pag1, cecropin b1, defensin gene a, or hp70.Type: ApplicationFiled: May 30, 2018Publication date: December 5, 2019Applicants: Academia Sinica, Chung Yuan Christian University, National Defense Medical CenterInventors: Yu-Chan CHAO, Nenavath Gopal NAIK, Tzong-Yuan WU, Chang-Chi LIN, Szu-Cheng KUO
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Publication number: 20190250161Abstract: Disclosed herein are recombinant baculoviruses suitable for detecting the presence of arthropod-borne viruses in a biological sample of a test subject. The information derived from the detection may also be used to render a diagnosis on whether the test subject is infected with the arthropod-borne viruses or not, so that proper course of treatment may be assigned to the subject.Type: ApplicationFiled: February 9, 2018Publication date: August 15, 2019Applicant: Chung Yuan Christian UniversityInventors: Tzong-Yuan WU, Szu-Cheng KUO, Pei-Yun SHU, Chang-Chi LIN, Der-Jiang CHIAO, Ying-Ju CHEN, Yi-Ting LIN, Shu-Fen CHANG, Chien-Ling SU
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Publication number: 20160250166Abstract: Disclosed herein is a method for the treatment of an infection with, or disease caused by, Chikungunya virus in a subject. The method includes administering to the subject a therapeutically effective amount of suramin as the active agent.Type: ApplicationFiled: May 10, 2016Publication date: September 1, 2016Inventors: Szu-Cheng KUO, Tzong-Yuan WU, Chang-Chi LIN, Yu-Ming WANG, Ying-Ju CHEN
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Patent number: 9381175Abstract: Disclosed herein is a method for the treatment of an infection with, or disease caused by, Chikungunya virus in a subject. The method includes administering to the subject a therapeutically effective amount of suramin as the active agent.Type: GrantFiled: May 28, 2014Date of Patent: July 5, 2016Assignees: CHUNG YUAN CHRISTIAN UNIVERSITY, NATIONAL DEFENSIVE MEDICAL CENTERInventors: Szu-Cheng Kuo, Tzong-Yuan Wu, Chang-Chi Lin, Yu-Ming Wang, Ying-Ju Chen
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Patent number: 9328147Abstract: Disclosed herein is a recombinant viral construct and its uses thereof. The recombinant viral construct is capable of simultaneously expressing three exogenous proteins, including a classical swine fever virus (CSFV) antigen, a porcine circovirus type 2 (PCV2) antigen, and an immunomodulatory protein. The recombinant viral construct is hence useful as a bio-tool for simultaneously producing multiple antigens of a bi-subunit vaccine.Type: GrantFiled: September 5, 2014Date of Patent: May 3, 2016Assignee: CHUNG YUAN CHRISTIAN UNIVERSITYInventors: Tzong-Yuan Wu, Mean-Shine Chen, Chao-Yi Teng, Ying-Ju Chen
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Publication number: 20160068575Abstract: Disclosed herein is a recombinant viral construct and its uses thereof. The recombinant viral construct is capable of simultaneously expressing three exogenous proteins, including a classical swine fever virus (CSFV) antigen, a porcine circovirus type 2 (PCV2) antigen, and an immunomodulatory protein. The recombinant viral construct is hence useful as a bio-tool for simultaneously producing multiple antigens of a bi-subunit vaccine.Type: ApplicationFiled: September 5, 2014Publication date: March 10, 2016Inventors: TZONG-YUAN WU, MEAN-SHINE CHEN, CHAO-YI TENG, YING-JU CHEN
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Patent number: 9267113Abstract: Disclosed herein is an Autographa californica multiple nucleopolyhedrovirus (AcMNPV) based hybrid baculovirus and its uses thereof. The AcMNPV based hybrid baculovirus is capable of infecting different hosts, and comprises Maruca vitrata multiple nucleopolyhedrovirus (MaviMNPV) genes of lef1, orf1629, pk1, CDS1, CDS2, and lef2; and AcMNPV/MaviMNPV-hybrid genes of egt and orf152. The AcMNPV based hybrid baculovirus is therefore useful as a bio-insecticide by its capability of delivering genes of toxic proteins to be expressed in at least two different insect hosts.Type: GrantFiled: March 10, 2014Date of Patent: February 23, 2016Assignee: CHUNG YUAN CHRISTIAN UNIVERSITYInventors: Tzong-Yuan Wu, Mean-Shine Chen, Chao-Yi Teng, Ying-Ju Chen, Chung-Hsiung Wang
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Publication number: 20150342911Abstract: Disclosed herein is a method for the treatment of an infection with, or disease caused by, Chikungunya virus in a subject. The method includes administering to the subject a therapeutically effective amount of suramin as the active agent.Type: ApplicationFiled: May 28, 2014Publication date: December 3, 2015Applicants: National Defensive Medical Center, Chung Yuan Christian UniversityInventors: Szu-Cheng Kuo, Tzong-Yuan Wu, Chang-Chi Lin, Yu-Ming Wang, Ying-Ju Chen
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Patent number: 9157072Abstract: Disclosed herein is an Autographa californica multiple nucleopolyhedrovirus (AcMNPV) based hybrid baculovirus and its uses thereof. The AcMNPV based hybrid baculovirus is capable of infecting different hosts, and comprises Bombyx mori nuclear polyhedrosis virus (BmNPV) genes of lef9, vlf1, p6.9, and vp80; Maruca vitrata multiple nucleopolyhedrovirus (MaviMNPV) genes of lef2, orf1629, and pe38; and AcMNPV/BmNPV/MaviMNPV-hybrid genes of pk1, lef8, DNA pol, GP41, helicase, orf94, VP1054, orf65, lef4, lef5, and orf99. The AcMNPV based hybrid baculovirus is therefore useful as a bio-tool or bio-insecticide for its capability of delivering genes for production or expression of toxic proteins in at least three different insect hosts.Type: GrantFiled: May 15, 2014Date of Patent: October 13, 2015Assignee: CHUNG YUAN CHRISTIAN UNIVERSITYInventors: Tzong-Yuan Wu, Mean-Shine Chen, Chao-Yi Teng, Ying-Ju Chen
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Publication number: 20150252332Abstract: Disclosed herein is an Autographa californica multiple nucleopolyhedrovirus (AcMNPV) based hybrid baculovirus and its uses thereof. The AcMNPV based hybrid baculovirus is capable of infecting different hosts, and comprises Maruca vitrata multiple nucleopolyhedrovirus (MaviMNPV) genes of lef1, orf1629, pk1, CDS1, CDS2, and lef2; and AcMNPV/MaviMNPV-hybrid genes of egt and orf152. The AcMNPV based hybrid baculovirus is therefore useful as a bio-insecticide by its capability of delivering genes of toxic proteins to be expressed in at least two different insect hosts.Type: ApplicationFiled: March 10, 2014Publication date: September 10, 2015Applicant: CHUNG YUAN CHRISTIAN UNIVERSITYInventors: Tzong-Yuan Wu, Mean-Shine Chen, Chao-Yi Teng, Ying-Ju Chen, Chung-Hsiung Wang
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Publication number: 20150252333Abstract: Disclosed herein is an Autographa californica multiple nucleopolyhedrovirus (AcMNPV) based hybrid baculovirus and its uses thereof. The AcMNPV based hybrid baculovirus is capable of infecting different hosts, and comprises Bombyx mori nuclear polyhedrosis virus (BmNPV) genes of lef9, vlf1, p6.9, and vp80; Maruca vitrata multiple nucleopolyhedrovirus (MaviMNPV) genes of lef2, orf1629, and pe38; and AcMNPV/BmNPV/MaviMNPV-hybrid genes of pk1, lef8, DNA pol, GP41, helicase, orf94, VP1054, orf65, lef4, lef5, and orf99. The AcMNPV based hybrid baculovirus is therefore useful as a bio-tool or bio-insecticide for its capability of delivering genes for production or expression of toxic proteins in at least three different insect hosts.Type: ApplicationFiled: May 15, 2014Publication date: September 10, 2015Applicant: CHUNG YUAN CHRISTIAN UNIVERSITYInventors: Tzong-Yuan Wu, Mean-Shine Chen, Chao-Yi Teng, Ying-Ju Chen
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Publication number: 20140087372Abstract: Disclosed herein is a hairpin probe for detecting a target pathogenic microorganism in a sample. The hairpin probe includes a microbead and an oligonucleotide having its 3?-end coupled to the microbead. The oligonucleotide includes, from 5? to 3?, a Tag sequence hybridizable to a specific identification sequence of the pathogenic microorganism, an internal control sequence having at least four words each having 4 nucleotides with a 75% AT-content, an anti-Tag sequence being a reverse complement of the Tag sequence, and a tail having at least two consecutive thymidine residues. The Tag and anti-Tag sequences are operable to form a stem of the hairpin probe with the internal control sequence being a loop. Also disclosed herein are, a kit including the hairpin probe and a method for using the kit in the detection of a target pathogenic microorganism.Type: ApplicationFiled: September 27, 2012Publication date: March 27, 2014Applicant: CHUNG YUAN CHRISTIAN UNIVERSITYInventors: Chung-Yung CHEN, Tzong-Yuan WU
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Patent number: 8679808Abstract: The present invention discloses a method for fabricating aerogels, a method for fabricating surface-modified aerogels, and a method for fabricating biocomposites. Take the fabricating method of biocomposites for example, first, a precursor solution is provided and the precursor solution comprises a hydrophilic ionic liquid, a catalyzed hydrolysis and/or condensation reagent, at least one biomolecule. Next, a curing process is performed for the precursor solution to hydrolyze and polymerize the at least one alkoxide monomer and/or aryloxide monomer to wrap at least one biomolecule and thus form biocomposite. Afterwards, an extracting process is performed by a solvent for the biocomposite to substitute the ionic liquid in the biocomposite. Finally, a drying process for the biocomposite is carried out after the extracting process so as to remove the solvent in the biocomposite. Therefore, the biocomposite is formed.Type: GrantFiled: November 17, 2010Date of Patent: March 25, 2014Assignee: Chung Yuan Christian UniversityInventors: Yui-Whei Chen-Yang, Yen-Kuang Li, Ching-Yao Yuan, Tzong-Yuan Wu
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Patent number: 8367404Abstract: An improved baculovirus vector capable of expressing genes in mammalian or insect host cells, and the uses thereof are disclosed. The improved baculovirus vector includes in sequence: a promoter; a first nucleic acid operably linked to the promoter for expressing a first protein in the mammalian or insect host cells; a chimera internal ribosomal entry site (IRES) comprising a portion of an enterovirus (EV) IRES sequence at least 90% identical to SEQ ID NO: 1 and a portion of a Rhopalosiphum padi virus (RhPV) IRES sequence at least 90% identical to SEQ ID NO: 2; and a second nucleic acid operable linked to the portion of the RhPV IRES sequence for expressing a second protein in the mammalian or insect host cells.Type: GrantFiled: March 13, 2011Date of Patent: February 5, 2013Assignee: Chung Yuan Christian UniversityInventors: Tzong-Yuan Wu, Ming-Kun Liu
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Publication number: 20120231536Abstract: An improved baculovirus vector capable of expressing genes in mammalian or insect host cells, and the uses thereof are disclosed. The improved baculovirus vector includes in sequence: a promoter; a first nucleic acid operably linked to the promoter for expressing a first protein in the mammalian or insect host cells; a chimera internal ribosomal entry site (IRES) comprising a portion of an enterovirus (EV) IRES sequence at least 90% identical to SEQ ID NO: 1 and a portion of a Rhopalosiphum padi virus (RhPV) IRES sequence at least 90% identical to SEQ ID NO: 2; and a second nucleic acid operable linked to the portion of the RhPV IRES sequence for expressing a second protein in the mammalian or insect host cells.Type: ApplicationFiled: March 13, 2011Publication date: September 13, 2012Applicant: Chung Yuan Christian UniversityInventors: Tzong-Yuan WU, Ming-Kun Liu
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Publication number: 20120107192Abstract: The present invention discloses a biochip comprising a substrate and a three-dimensional mesoporous layer on top of it, wherein the mesoporous layer on top is chemically modified to recognize labeling DNAs, proteins, peptides, saccharides, and cells. In addition, this invention also discloses a method for forming the biochip with a three-dimensional mesoporous layer, including a blending process, a heating process, a coating process, a gelation process, a drying process, and a surface modification process.Type: ApplicationFiled: December 23, 2011Publication date: May 3, 2012Applicant: CHUNG YUAN CHRISTIAN UNIVERSITYInventors: YUI-WHEI CHEN-YANG, TZONG-YUAN WU, YEN-KUANG LI, HUAN-CHING YANG