Patents by Inventor Tzu-Chih Chen
Tzu-Chih Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11964881Abstract: A method for making iridium oxide nanoparticles includes dissolving an iridium salt to obtain a salt-containing solution, mixing a complexing agent with the salt-containing solution to obtain a blend solution, and adding an oxidating agent to the blend solution to obtain a product mixture. A molar ratio of a complexing compound of the complexing agent to the iridium salt is controlled in a predetermined range so as to permit the product mixture to include iridium oxide nanoparticles.Type: GrantFiled: July 27, 2020Date of Patent: April 23, 2024Assignee: NATIONAL YANG MING CHIAO TUNG UNIVERSITYInventors: Pu-Wei Wu, Yi-Chieh Hsieh, Han-Yi Wang, Kuang-Chih Tso, Tzu-Ying Chan, Chung-Kai Chang, Chi-Shih Chen, Yu-Ting Cheng
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Publication number: 20240128252Abstract: The present application discloses a semiconductor structure. The semiconductor structure a top die and a bottom die, and the maximum die size is constrained to reticle dimension. Each die includes (1) core: computation circuits, (2) phy: analog circuit connecting to memory, (3) I/O: analog circuit connecting output elements, (4) SERDES: serial high speed analog circuit, (5) intra-stack connection circuit, and (6) cache memory. This semiconductor structure can be chapleted design for high wafer yield with least tape out masks for cost saving. The intra-stack connection circuit connects the top die and the bottom die in the shortest distance (about tens of micrometers), so as to provide high signal quality and power efficiency.Type: ApplicationFiled: October 17, 2022Publication date: April 18, 2024Inventors: TZU-WEI CHIU, CHUN-WEI CHANG, SHANG-PIN CHEN, WEI-CHIH CHEN, CHE-YEN HUANG
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Publication number: 20240120282Abstract: The present application discloses a semiconductor structure and methods for manufacturing semiconductor structures. The semiconductor structure includes a plurality of bottom dies and a top die stacked on the bottom dies. The bottom dies receive power supplies through tiny through silicon vias (TSVs) formed in backside substrates of the bottom dies, while the top die receives power supplies through dielectric vias (TDVs) formed in a dielectric layer that covers the bottom dies. By enabling backside power delivery to the bottom die, more space can be provided for trace routing between stacked dies. Therefore, greater computation capability can be achieved within a smaller chip area with less power loss.Type: ApplicationFiled: February 20, 2023Publication date: April 11, 2024Inventors: TZU-WEI CHIU, CHUN-WEI CHANG, SHANG-PIN CHEN, WEI-CHIH CHEN, CHE-YEN HUANG
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Publication number: 20240111827Abstract: The present disclosure provides a matrix device and an operation method thereof. The matrix device includes a transpose circuit and a memory. The transpose circuit is configured to receive a first element string representing a native matrix from a matrix source, wherein all elements in the native matrix are arranged in the first element string in one of a “row-major manner” and a “column-major manner”. The transpose circuit transposes the first element string into a second element string, wherein the second element string is equivalent to an element string in which all elements of the native matrix are arranged in another one of the “row-major manner” and the “column-major manner”. The memory is coupled to the transpose circuit to receive the second element string.Type: ApplicationFiled: November 2, 2022Publication date: April 4, 2024Applicant: NEUCHIPS CORPORATIONInventors: Huang-Chih Kuo, YuShan Ruan, Jian-Wen Chen, Tzu-Jen Lo
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Patent number: 10493126Abstract: The invention generally relates to an immunomodulatory protein and a chemotherapeutic agent for simultaneous, contemporaneous or sequential use in the treatment of diseases, more particularly of proliferative diseases, still more particularly of cancer(s), to a combination of an FIP and a chemotherapeutic agent, as well as to the medical and biotechnological applications thereof, more particularly in the field of the treatment of diseases, more particularly of proliferative diseases, still more particularly of cancer(s).Type: GrantFiled: March 12, 2015Date of Patent: December 3, 2019Assignee: YEASTERN BIOTECH CO., LTD.Inventors: Jiunn-Liang Ko, Ting-Yi Hou, Ming-Fang Wu, Tzu-Chih Chen
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Publication number: 20170368119Abstract: The present invention provides the use of a fungal immunomodulatory protein (FIP) in manufacturing a medicament for inhibiting hepatocyte growth factor receptor (HGFR) activity in a cell, and for treating HGFR-associated cancer.Type: ApplicationFiled: August 28, 2015Publication date: December 28, 2017Applicant: YEASTERN BIOTECH CO., LTDInventors: Wen-Sheng Wu, Jia-Ru Wu, Chi-Tan Hu, Ren-In You, Pei-Ling Ma, Tzu-Chih Chen
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Publication number: 20170173110Abstract: The invention generally relates to an immunomodulatory protein and a chemotherapeutic agent for simultaneous, contemporaneous or sequential use in the treatment of diseases, more particularly of proliferative diseases, still more particularly of cancer(s), to a combination of an FIP and a chemotherapeutic agent, as well as to the medical and biotechnological applications thereof, more particularly in the field of the treatment of diseases, more particularly of proliferative diseases, still more particularly of cancer(s).Type: ApplicationFiled: March 12, 2015Publication date: June 22, 2017Applicant: YEASTERN BIOTECH CO., LTDInventors: Jiunn-Liang Ko, Ting-Yi Hou, Ming-Fang Wu, Tzu-Chih Chen
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Patent number: 8629096Abstract: This invention relates to a method for stimulation or an activation of immunological function directed to activate natural killer cells and macrophages or increase production of serum antibody in a patient in need of such stimulation or activation, comprising administering an isolated and/or purified polypeptide of a fungal immunomodulatory protein. This invention also relates to a method for suppressing proliferation of a cancer cell and a method for suppressing a tumor cell mobility, comprising providing to the tumor cell a purified polypeptide of a fungal immunomodulatory protein.Type: GrantFiled: March 16, 2012Date of Patent: January 14, 2014Assignee: Yeastern Biotech Co., Ltd.Inventors: Jiunn-Liang Ko, Tzu-Chih Chen
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Patent number: 8628785Abstract: The present invention relates to a method for augmenting the immunogenicity of an antigen in a mammal, comprising immunizing the mammal with a composition comprising the antigen, and an adjuvant in an amount of effective to augment the immunogenicity of said antigen, wherein the adjuvant comprises a Ling-Zhi-8 (LZ-8) protein.Type: GrantFiled: June 17, 2011Date of Patent: January 14, 2014Assignee: Yeastern Biotech Co., LtdInventors: Ching-Liang Chu, Tzu-Chih Chen
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Publication number: 20130344105Abstract: The present invention relates to a method for augmenting the immunogenicity of an antigen in a mammal, comprising immunizing the mammal with a composition comprising the antigen, and an adjuvant in an amount of effective to augment the immunogenicity of said antigen, wherein the adjuvant comprises a Ling-Zhi-8 (LZ-8) protein.Type: ApplicationFiled: August 12, 2013Publication date: December 26, 2013Inventors: Ching-Liang Chu, Tzu-Chih Chen
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Publication number: 20120177674Abstract: This invention relates to a method for stimulation or an activation of immunological function directed to activate natural killer cells and macrophages or increase production of serum antibody in a patient in need of such stimulation or activation, comprising administering an isolated and/or purified polypeptide of a fungal immunomodulatory protein. This invention also relates to a method for suppressing proliferation of a cancer cell and a method for suppressing a tumor cell mobility, comprising providing to the tumor cell a purified polypeptide of a fungal immunomodulatory protein.Type: ApplicationFiled: March 16, 2012Publication date: July 12, 2012Applicant: YEASTERN BIOTECH CO., LTD.Inventors: Jiunn-Liang Ko, Tzu-Chih Chen
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Patent number: 8163519Abstract: The invention relates to an improved nucleic acid molecule encoding fungal immunomodulatory protein (FIP) that is better expressed in fungi, to vectors comprising the nucleic acid molecule, to hosts transformed with said vectors, to processes of expressing the protein of the invention in said transformed hosts, to the protein of the invention produced by said processes, to uses of said hosts comprising the protein of the invention and to a process of purifying FIP. The protein of the invention has wide immunomodulatory activity. Thus, the present invention further relates to uses of the protein of the invention in cosmetic or pharmaceutical compositions and to food or feed additives comprising the protein of the invention. Finally, the invention relates to the method of modulating immunological activities by orally administering FIP or proteins fused with FIP to a subject.Type: GrantFiled: September 14, 2004Date of Patent: April 24, 2012Inventors: Jiunn-Liang Ko, Yu-Lu Huang, Tzu-Chih Chen, Hsu-Wei Hung, Ho-Lung Jiang, Ching-Lung Hu, Cheng-Chun Kuan, Hsuan-Ju Thou
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Publication number: 20110280906Abstract: The present invention relates to a method for augmenting the immunogenicity of an antigen in a mammal, comprising immunizing the mammal with a composition comprising the antigen, and an adjuvant in an amount of effective to augment the immunogenicity of said antigen, wherein the adjuvant comprises a Ling-Zhi-8 (LZ-8) protein.Type: ApplicationFiled: June 17, 2011Publication date: November 17, 2011Applicant: YEASTERN BIOTECH CO., LTDInventors: Ching-Liang Chu, Tzu-Chih Chen
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Patent number: 7820443Abstract: The invention relates to a fast method of transforming competent cells, comprising: a. mixing a plasmid DNA with the competent cells suspending within ionic solution to form a mixture; b. plating the mixture on a warm selective medium; and c. culturing the mixture on the medium; wherein the ionic solution comprises divalent cation selected from the group consisting of Ca2+, Mg2+, Mn2+, Zn2+, Cu2+, Cd2+, Fe2+, Sr2+ and Co2+, and provided that the ionic solution does not include Ca2+ alone.Type: GrantFiled: March 8, 2006Date of Patent: October 26, 2010Assignee: Yeastern Biotech Co., Ltd.Inventor: Tzu-Chih Chen
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Publication number: 20100009915Abstract: This invention relates to a method for stimulation or an activation of immunological function directed to activate natural killer cells and macrophages or increase production of serum antibody in a patient in need of such stimulation or activation, comprising administering an isolated and/or purified polypeptide of a fungal immunomodulatory protein. This invention also relates to a method for suppressing proliferation of a cancer cell and a method for suppressing a tumor cell mobility, comprising providing to the tumor cell a purified polypeptide of a fungal immunomodulatory protein.Type: ApplicationFiled: July 6, 2009Publication date: January 14, 2010Applicant: YEASTERN BIOTECH CO., LTD.Inventors: JIUNN-LIANG KO, TZU-CHIH CHEN
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Publication number: 20090285789Abstract: The present invention is related to a method for enhancing innate and adaptive immunity by activating dendritic cells (DCs) and macrophages, comprising administering a subject LZ-8 protein. The present invention is also related to a composition for enhancing innate and adaptive immunity, comprising LZ-8 protein.Type: ApplicationFiled: May 15, 2009Publication date: November 19, 2009Applicant: YEASTERN BIOTECH CO., LTDInventors: Ching-Liang Chu, Tzu-Chih Chen
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Publication number: 20090042776Abstract: The invention relates to an improved nucleic acid molecule encoding fungal immunomodulatory protein (FIP) that is better expressed in fungi, to vectors comprising the nucleic acid molecule, to hosts transformed with said vectors, to processes of expressing the protein of the invention in said transformed hosts, to the protein of the invention produced by said processes, to uses of said hosts comprising the protein of the invention and to a process of purifying FIP. The protein of the invention has wide immunomodulatory activity. Thus, the present invention further relates to uses of the protein of the invention in cosmetic or pharmaceutical compositions and to food or feed additives comprising the protein of the invention. Finally, the invention relates to the method of modulating immunological activities by orally administering FIP or proteins fused with FIP to a subject.Type: ApplicationFiled: September 14, 2004Publication date: February 12, 2009Inventors: Jiunn-Liang Ko, Yu-Lu Huang, Tzu-Chih Chen, Hsu-Wei Hung, Ho-Lung Jiang, Ching-Lung Hu, Cheng-Chun Kuan, Hsuan-Ju Thou
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Patent number: 7364883Abstract: The present invention is directed to a process of producing novel fatty acids in oleaginous yeast by producing oleaginous yeast by introducing into the yeast genes coding for enzymes selected from the group consisting of D5-desaturase, D6-desaturase, D12-desaturase, D15-desaturase and elongase; and culturing the yeast in the medium containing high levels of carbon sources. The present invention is further directed to a residue or fatty acid that is obtained from pressing the oleaginous yeast produced by the process of the invention.Type: GrantFiled: May 6, 2005Date of Patent: April 29, 2008Assignee: Yeastern BioTech Co., Ltd.Inventor: Tzu-Chih Chen
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Publication number: 20070212783Abstract: The invention relates to a fast method of transforming competent cells, comprising: a. mixing a plasmid DNA with the competent cells suspending within ionic solution to form a mixture; b. plating the mixture on a warm selective medium; and c. culturing the mixture on the medium; wherein the ionic solution comprises divalent cation selected from the group consisting of Ca2+, Mg2+, Mn2+, Zn2+, Cu2+, Cd2+, Fe2+, Sr2+ and Co2+, and provided that the ionic solution does not include Ca2+ alone.Type: ApplicationFiled: March 8, 2006Publication date: September 13, 2007Inventor: Tzu-Chih Chen
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Patent number: 7098033Abstract: A fast method of transforming competent cells is described. The competent cells are thawed at room temperature or in a water bath. Plasmid DNAs and competent cells are mixed together, then the mixture is subject to heat shock treatment. After plating the mixture on a low-temperature selective medium by a low-temperature plating tool, the competent cells are cultured on the selective medium.Type: GrantFiled: January 26, 2005Date of Patent: August 29, 2006Assignee: Yeastern Biotech Co., Ltd.Inventors: Tzu-Chih Chen, Wei-Ni Hua