Abstract: IL-12 variants are provided. Also provided are antibodies that specifically bind to PD1. Also provided are fusion proteins of IL-12 variants and anti-PD1 antibodies. Also provided are uses of these IL-12 variants, anti-PD1 antibodies, fusion proteins, and related compositions and methods.

Abstract: A brain tumor types distinguish system includes an image outputting device and a server computing device. The image outputting device outputs at least three brain images captured from the position of a brain tumor. The server computing device pre-stores a plurality of distinguish pathways corresponding to different types of brain tumors. The server computing device includes an image receiving module, an image pre-processing module, a data comparison module and a distinguish module. The image receiving module receives the brain images. The image pre-processing module pre-processes the brain images to obtain corresponding processed images thereof. The data comparison module compares the brain images and the processed images with the distinguish pathways to obtain at least three comparison results. The distinguish module statistically analyzes the comparison results to obtain a distinguish result.

Abstract: A benign tumor development trend assessment system includes an image outputting device and a server computing device. The image outputting device outputs first/second images captured from the same position in a benign tumor. The server computing device includes an image receiving module, an image pre-processing module, a target extracting module, a feature extracting module and a trend analyzing module. The image receiving module receives the first/second images. The image pre-processing module pre-processes the first/second images to obtain first/second local images. The target extracting module automatically detects and delineates tumor regions from the first/second local images to obtain first/second region of interest (ROI) images. The feature extracting module automatically identifies the first/second ROI images to obtain at least one first/second features. The trend analyzing module analyzes the first/second features to obtain a tumor development trend result.

Abstract: A method for enhancing an accuracy of a benign tumor development trend assessment system includes: a first processing procedure, an image captured before the treatment is inputted to and be processed by a server computing device of the benign tumor development trend assessment system to obtain a first processing result; a second processing procedure, the images captured before and in at least one period after the treatment are inputted to and processed by the server computing device to obtain a second processing result; a trend analyzing procedure, the trend analyzing module of the server computing device analyzes the first processing result, the second processing result and the trend pathways to obtain a tumor development trend result; and a storing procedure, the first processing result, the second processing result and the tumor development trend result are transformed to an individual trend pathway which is stored in the trend analyzing module.

Abstract: A benign tumor development trend assessment system includes an image outputting device and a server computing device. The image outputting device outputs first/second images captured from the same position in a benign tumor. The server computing device includes an image receiving module, an image pre-processing module, a target extracting module, a feature extracting module and a trend analyzing module. The image receiving module receives the first/second images. The image pre-processing module pre-processes the first/second images to obtain first/second local images. The target extracting module automatically detects and delineates tumor regions from the first/second local images to obtain first/second region of interest (ROI) images. The feature extracting module automatically identifies the first/second ROI images to obtain at least one first/second features. The trend analyzing module analyzes the first/second features to obtain a tumor development trend result.

Abstract: A pressure sensor includes a conductive substrate, a ring-shaped spacer, an inner spacer and a sensing circuit substrate. The conductive substrate includes a conductive-substrate body and a conductive layer. The conductive layer is disposed on the conductive-substrate body. The ring-shaped spacer and the inner spacer are disposed on the conductive-substrate body. The sensing-circuit substrate, disposed on the ring-shaped spacer and the inner spacer, includes a circuit-substrate body, a first sensing circuit and a second sensing circuit. The first sensing circuit and the second sensing circuit are disposed on opposing sides of the circuit-substrate body, and a plurality of first finger circuits of the first sensing circuit and a plurality of second finger circuits of the second sensing circuit are interlaced. The first sensing circuit and the second sensing circuit are densely arranged at the center of the conductive layer and less densely arranged on both sides of the conductive layer.

Abstract: A pressure sensor includes a conductive substrate, a ring-shaped spacer, an inner spacer and a sensing circuit substrate. The conductive substrate includes a conductive-substrate body and a conductive layer. The conductive layer is disposed on the conductive-substrate body. The ring-shaped spacer and the inner spacer are disposed on the conductive-substrate body. The sensing-circuit substrate, disposed on the ring-shaped spacer and the inner spacer, includes a circuit-substrate body, a first sensing circuit and a second sensing circuit. The first sensing circuit and the second sensing circuit are disposed on opposing sides of the circuit-substrate body, and a priority of first finger circuits of the first sensing circuit and a priority of second finger circuits of the second sensing circuit are interlaced. The first sensing circuit and the second sensing circuit are densely arranged at the center of the conductive layer and less densely arranged on both sides of the conductive layer.

Abstract: A stretch sensor includes a first elastic insulating layer, a first elastic conductive layer, an elastic dielectric layer, a second elastic conductive layer and a second elastic insulating layer sequentially piled together thereon. The first and the second elastic insulating layers include the same elastic resin, and the first and the second elastic conductive layer include the same elastic resin and the same conductive material. The elastic dielectric layer includes the elastic resin and a dielectric material, in which the dielectric material comprises at least one of an Sr1-xCaxTiO3 compound, an Sr1-yBayTiO3 compound, and a BaTiO3 compound so as to make the dielectric constant of the dielectric material within 15.65-2087.3 F/m.

Abstract: A bend sensor includes a flexible circuit substrate, an insulation pad and a flexible conductive substrate. The flexible circuit substrate includes an insulating body, a first circuit and a second circuit. The first and second circuits are disposed on opposing sides of the insulating body. The first circuit has first fingers, while the second circuit has second fingers. The insulation pad disposed on the insulating body exposes the first and second fingers. The flexible conductive substrate disposed on the insulating pad has a conductive layer separated from the first fingers and the second fingers. While the bend sensor is bent, the conductive layer on the flexible conductive substrate would deform toward the flexible circuit substrate so as to form multiple contacts with the first and second fingers. Through these contacts, a number of resistors are formed to contribute a detectable resistance for the corresponding bending amplitude to be further realized.

Abstract: A lamination type stretch sensor includes a first elastic insulating layer, a first elastic conductive layer, an elastic dielectric layer, a second elastic conductive layer and a second elastic insulating layer sequentially piled together thereon. The first elastic conductive layer includes a plurality of first coupling sections and a plurality of first connecting sections. The second elastic conductive layer includes a plurality of second coupling sections and a plurality of second connecting sections disposed between the second coupling sections. The elastic dielectric layer is deposited between the first elastic conductive layer and the second elastic conductive layer.

Abstract: A slide type variable resistor with a resistance adjusting member, comprising a housing, two side rails, a circuit module, a control member and a base. The housing includes a housing limiting hole and a space. The two side rails are disposed in the space. The circuit module is disposed in the space and has a resistive circuit. The control member is disposed in the space. The control member includes an object, at least one metal brush, a handle and an elastic member. The object having a bump, and the elastic member is sleeved at the bump.

Abstract: A variable resistor with a light emitting element includes a circuit board, a housing and a slide assembly. The circuit board extending in a longitudinal direction has a circuit arrangement surface to arrange thereon a resistive circuit and a power circuit. The housing fixed to the circuit board so as to form a slide space has a sliding slot extending in the longitudinal direction. The slide assembly further includes a slidable member, a fader set, a light emitting element, a resistive circuit brush and two light-emitting element brushes. The fader set fixed at the slidable member penetrates the sliding slot. The light emitting element in an accommodating groove of the slidable member projects a light beam toward the fader set. The resistive circuit brush electrically connects the resistive circuit. The two light-emitting element brushes electrically bridge the power circuit and the light emitting element.

Abstract: A finger movement-sensing assembly includes a flexible substrate, a bend-sensing circuit structure and a depression-sensing circuit structure. The flexible substrate extends in a first direction for use on a finger. The flexible substrate has an outer extension section and an inner deflection section. The outer extension section is applied to be mounted onto a back of the finger, and the inner deflection section is applied to be mounted onto a pulp of the finger. The bend-sensing circuit structure is disposed on the outer extension section to produce a bend-sensing signal. The depression-sensing circuit structure is disposed on the inner deflection section to produce a depression-sensing signal.

Abstract: Novel chimeric moieties that show significant efficacy against cancers are provided. In certain embodiments the chimeric moieties comprise a targeting moiety attached to an interferon. In certain embodiments, the chimeric moieties comprise fusion proteins where an antibody that specifically binds to a cancer marker is fused to interferon alpha (IFN-?) or interferon beta (IFN-?).

Abstract: A rotary variable resistor includes a resistance circuit module, a fixation frame, a brush assembly and a rotor shaft. The resistance circuit module has a circuit board, an output circuit, three input circuits and a resistance ring. The output circuit includes a brush contact port having an annular brush contact area and an output port extending out from the brush contact port. Each input circuit has a resistor contact end and an input port. The three resistor contact ends are evenly annularly separated. The resistance ring co-axially and annularly spaced to the brush contact port contacts the resistor contact ends. The fixation frame is fixedly mounted on the resistance circuit module. The brush assembly rotatably restrained by the fixation frame bridges the annular brush contact area and the resistance ring. The rotor shaft for driving the brush assembly is connected with the brush assembly.

Abstract: A finger movement-sensing assembly includes a flexible substrate, a bend-sensing circuit structure and a depression-sensing circuit structure. The flexible substrate extends in a first direction for use on a finger. The flexible substrate has an outer extension section and an inner deflection section. The outer extension section is applied to be mounted onto a back of the finger, and the inner deflection section is applied to be mounted onto a pulp of the finger. The bend-sensing circuit structure is disposed on the outer extension section to produce a bend-sensing signal. The depression-sensing circuit structure is disposed on the inner deflection section to produce a depression-sensing signal.

Abstract: A tone map selecting device includes: a bit-number-per-symbol providing circuit, providing a plurality of bit numbers per symbol, each of which associated with a tone map; a calculating circuit, performing a predetermined calculation on the bit numbers per symbol to generate a calculation result; and a selecting circuit, identifying one of the bit numbers per symbol that satisfies a predetermined relationship with the calculation result, and selecting the tone map associated with the bit number per symbol satisfying the predetermined relationship as a default tone map.

Abstract: A lamination type stretch sensor includes a first elastic insulating layer, a first elastic conductive layer, an elastic dielectric layer, a second elastic conductive layer and a second elastic insulating layer sequentially piled together thereon. The first elastic conductive layer includes a plurality of first coupling sections and a plurality of first connecting sections. The second elastic conductive layer includes a plurality of second coupling sections and a plurality of second connecting sections disposed between the second coupling sections. The elastic dielectric layer is deposited between the first elastic conductive layer and the second elastic conductive layer.

Abstract: A stretch sensor includes a first elastic insulating layer, a first elastic conductive layer, an elastic dielectric layer, a second elastic conductive layer and a second elastic insulating layer sequentially piled together thereon. The first and the second elastic insulating layers include the same elastic resin, and the first and the second elastic conductive layer include the same elastic resin and the same conductive material. The elastic dielectric layer includes the elastic resin and a dielectric material, in which the dielectric material comprises at least one of an Sr1-xCaxTiO3 compound, an Sr1-yBayTiO3 compound, and a BaTiO3 compound so as to make the dielectric constant of the dielectric material within 15.65-2087.3 F/m.

Abstract: A transmitting circuit is disposed in an electronic device, which performs signal transmission with another electronic device through an Ethernet over Coax (EoC) system. The transmitting circuit includes a control circuit, a gain adjusting circuit and an output circuit. The control circuit obtains a tone map from the other electronic device, calculates a signal quality parameter according to the tone map, and determines a gain according to the signal quality parameter. The gain adjusting circuit, coupled to the control circuit, adjusts the strength of a signal according to the gain to generate an adjusted signal. The output circuit, coupled to the gain adjusting circuit, transmits the adjusted signal to the other electronic device.