Patents by Inventor Tzu-Yin Lin
Tzu-Yin Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250079237Abstract: A metal interconnect structure includes a first metal interconnection in an inter-metal dielectric (IMD) layer on a substrate, a second metal interconnection on the first metal interconnection, and a cap layer between the first metal interconnection and the second metal interconnection. Preferably, a top surface of the first metal interconnection is even with a top surface of the IMD layer and the cap layer is made of conductive material.Type: ApplicationFiled: November 18, 2024Publication date: March 6, 2025Applicant: UNITED MICROELECTRONICS CORP.Inventors: Yi-How Chou, Tzu-Hao Fu, Tsung-Yin Hsieh, Chih-Sheng Chang, Shih-Chun Tsai, Kun-Chen Ho, Yang-Chou Lin
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Publication number: 20250079853Abstract: A power generating device and a power supplying method thereof are provided. The power generating device includes a battery set, a charge storage device, a charger and a voltage converter. The battery set has microbial fuel cell and/or solar battery, and is configured to generate a supply voltage. The charger generates a charging voltage according to the supply voltage, and provides the charging voltage through a first resistor to charge the charge storage device. The voltage converter converts a storage voltage provided by the charge storage device to generate a driving voltage, and provides the driving voltage to drive a load.Type: ApplicationFiled: October 20, 2023Publication date: March 6, 2025Applicant: National Tsing Hua UniversityInventors: Chao-I Liu, Heng-An Su, I-Chu Lin, Yao-Yu Lin, Chia-Chieh Hsu, Hsin-Tien Li, Tzu-Yin Liu, Han-Yi Chen
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Publication number: 20250079492Abstract: A plant microbial fuel cell includes a planting container, a plant, a cathode and an anode. The planting container has a culture medium therein, and a microbial population is in the culture medium. The plant is grown in the culture medium in the planting container. The cathode is disposed on a surface of the culture medium, and the anode is arranged in the culture medium close to roots of the plant. The anode includes a porous carbon material prepared from coffee grounds, and thus the overall cost of the plant microbial fuel cell may be greatly reduced, and the porous carbon material is easy to process and has high biocompatibility.Type: ApplicationFiled: October 19, 2023Publication date: March 6, 2025Applicant: National Tsing Hua UniversityInventors: Yao-Yu Lin, Hsin-Tien Li, Heng-An Su, Tzu-Yin Liu, Han-Yi Chen
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Publication number: 20250019426Abstract: The present disclosure relates to an anti-glucose-regulated protein 78 (GRP78) antibody or an antigen-binding fragment thereof. The present disclosure also relates to a method for treating and/or preventing a disease and/or disorder caused by or related to GRP78 activity or signaling, and a method or kit for detecting GRP78 or a cancer in a sample.Type: ApplicationFiled: July 3, 2024Publication date: January 16, 2025Applicant: UCT BIOSCIENCE CO., LTD.Inventors: CHIA-CHENG WU, YA-WEI TSAI, TZU-YIN LIN, CHIA-HSIANG LO
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Publication number: 20230076792Abstract: The present invention provides a compound of Formula (I) as defined herein. The present invention also provides a nanoparticle comprising a plurality of the conjugates of the present invention, and methods of using the nanoparticles for drug delivery, treating a disease, and methods of imaging.Type: ApplicationFiled: December 16, 2020Publication date: March 9, 2023Inventors: Yuanpei LI, Hao WU, Tzu-yin LIN
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Patent number: 10781265Abstract: A humanized anti-Globo H antibody, or an scFv or Fab fragment thereof, comprising a heavy-chain variable domain having three complementary regions consisting of HCDR1, HCDR2, and HCDR3 and a light-chain variable domain having three complementary regions consisting of LCDR1, LCDR2, and LCDR3, wherein the sequence of HCDR1 is GYISSDQILN (SEQ ID NO:4), the sequence of HCDR2 is RIYPVTGVTQYXHKFVG (SEQ ID NO:5, wherein X is any amino acid), and the sequence of HCDR3 is GETFDS (SEQ ID NO:6), wherein the sequence of LCDR1 is KSNQNLLX?SGNRRYZLV (SEQ ID NO:7, wherein X? is F, Y, or W, and Z is C, G, S or T), the sequence of LCDR2 is WASDRSF (SEQ ID NO:8), and the sequence of LCDR3 is QQHLDIPYT (SEQ ID NO:9).Type: GrantFiled: May 24, 2018Date of Patent: September 22, 2020Assignee: Development Center for BiotechnologyInventors: Chia-Cheng Wu, Szu-Liang Lai, Yu-Jung Chen, Chih-Yung Hu, Tzu-Yin Lin
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Publication number: 20200048365Abstract: A humanized anti-Globo H antibody, or an scFv or Fab fragment thereof, comprising a heavy-chain variable domain having three complementary regions consisting of HCDR1, HCDR2, and HCDR3 and a light-chain variable domain having three complementary regions consisting of LCDR1, LCDR2, and LCDR3, wherein the sequence of HCDR1 is GYISSDQILN (SEQ ID NO:4), the sequence of HCDR2 is RIYPVTGVTQYXHKFVG (SEQ ID NO:5, wherein X is any amino acid), and the sequence of HCDR3 is GETFDS (SEQ ID NO:6), wherein the sequence of LCDR1 is KSNQNLLX?SGNRRYZLV (SEQ ID NO:7, wherein X? is F, Y, or W, and Z is C, G, S or T), the sequence of LCDR2 is WASDRSF (SEQ ID NO:8), and the sequence of LCDR3 is QQHLDIPYT (SEQ ID NO:9).Type: ApplicationFiled: May 24, 2018Publication date: February 13, 2020Applicant: Development Center for BiotechnologyInventors: Chia-Cheng Wu, Szu-Liang Lai, Yu-Jung Chen, Chih-Yung Hu, Tzu-Yin Lin
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Publication number: 20180371088Abstract: An asymmetric heterodimeric antibody includes a knob structure formed in a CH3 domain of a first heavy chain; a hole structure formed in a CH3 domain of a second heavy chain, wherein the hole structure is configured to accommodate the knob structure so that a heterodimeric antibody is formed; and a T-cell targeting domain fused to the CH3 domain of the first heavy chain or the second heavy chain, wherein the T-cell targeting domain binds specifically to an antigen on the T-cell. The T-cell targeting domain is a ScFv or Fab derived from an anti-CD3 antibody. The asymmetric heterodimeric antibody may have L234A and L235A mutations or L235A and G237A such that its effector binding is compromised.Type: ApplicationFiled: June 22, 2018Publication date: December 27, 2018Applicant: Development Center for BiotechnologyInventors: Chia-Cheng WU, Tzu-Yin LIN, Chao-Yang HUANG, Yu-Jung CHEN, Jei-Hwa YU, Chen-Li CHIEN
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Publication number: 20180371089Abstract: A bispecific anti-Globo H antibody includes an anti-Globo H antibody that binds specifically to Globo H; and a T-cell targeting domain fused to a CH3 domain of a heavy chain of the anti-Globo H antibody, wherein the T-cell targeting domain binds specifically to an antigen on T-cells; and wherein the anti-Globo H antibody comprises mutations at an effector binding site such that the bispecific anti-Globo H antibody has a diminished effector function. The T-cell targeting domain is a ScFv or Fab from an anti-CD3 antibody.Type: ApplicationFiled: June 22, 2018Publication date: December 27, 2018Applicant: Development Center for BiotechnologyInventors: Chia-Cheng WU, Tzu-Yin LIN, Yu-Jung CHEN, Chao-Yang HUANG
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Patent number: 9965194Abstract: A data writing method, a memory control circuit unit and a memory storage apparatus are provided. The method includes: receiving a first write command and first data corresponding to the first write command, and writing the first data into a third physical erasing unit in first physical erasing units; and if a usage frequency of a fourth physical erasing unit in the first physical erasing units is less than a predetermined value, performing a data arrangement operation corresponding to the first write command to copy second data stored by the fourth physical to at least one of second physical erasing units.Type: GrantFiled: October 25, 2016Date of Patent: May 8, 2018Assignee: PHISON ELECTRONICS CORP.Inventors: Chin-Min Lin, Yueh-Hsuan Tsai, Tzu-Yin Lin
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Publication number: 20180067648Abstract: A data writing method, a memory control circuit unit and a memory storage apparatus are provided. The method includes: receiving a first write command and first data corresponding to the first write command, and writing the first data into a third physical erasing unit in first physical erasing units; and if a usage frequency of a fourth physical erasing unit in the first physical erasing units is less than a predetermined value, performing a data arrangement operation corresponding to the first write command to copy second data stored by the fourth physical to at least one of second physical erasing units.Type: ApplicationFiled: October 25, 2016Publication date: March 8, 2018Applicant: PHISON ELECTRONICS CORP.Inventors: Chin-Min Lin, Yueh-Hsuan Tsai, Tzu-Yin Lin
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Publication number: 20180036417Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.Type: ApplicationFiled: March 24, 2017Publication date: February 8, 2018Inventors: Kit S. LAM, Yuanpei LI, Chong-Xian PAN, Tzu-yin LIN
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Patent number: 9642916Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.Type: GrantFiled: March 14, 2013Date of Patent: May 9, 2017Assignee: The Regents of the University of CaliforniaInventors: Kit S. Lam, Yuanpei Li, Chong-Xian Pan, Tzu-yin Lin
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Publication number: 20150214394Abstract: An opto-electrical conversion structure includes a substrate, a first semiconductor structure, and a second semiconductor structure. The substrate has a first surface and a second surface opposite to each other. The first surface has a plurality of micro-structures and a plurality of nano-structures. The nano-structures are distributed on the surface of the micro-structures, and have heights of about 500 nm to about 900 nm. The first semiconductor structure is disposed on the first surface of the substrate. The second semiconductor structure is disposed on the second surface of the substrate.Type: ApplicationFiled: June 6, 2014Publication date: July 30, 2015Inventors: Ming-Yi HUANG, Po-Chuan YANG, Jr-Hau HE, Hsin-Ping WANG, Tzu-Yin LIN
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Publication number: 20140161719Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.Type: ApplicationFiled: March 14, 2013Publication date: June 12, 2014Applicant: The Regents of the University of CaliforniaInventors: Kit S. Lam, Yuanpei Li, ChongXian Pan, Tzu-yin Lin
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Publication number: 20110097302Abstract: This invention relates to protein-polymer conjugates described in the specification. Also disclosed are a method for preparing a protein-polymer conjugate and using such a conjugate in treating various immune disorders.Type: ApplicationFiled: July 16, 2010Publication date: April 28, 2011Inventors: Ta Tung Yuan, Shih-Hsien Chuang, Tzu-Yin Lin