Patents by Inventor Tzyy-Wen Jeng
Tzyy-Wen Jeng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140302505Abstract: Disclosed are example methods and systems to determine the quantity of an analyte initially present in a chemical and or biological reaction. Also disclosed are computer implemented methods and systems to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.Type: ApplicationFiled: April 25, 2014Publication date: October 9, 2014Inventors: Eric B. Shain, John M. Clemens, Tzyy-Wen Jeng, George J. Schneider
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Patent number: 8315681Abstract: A method for noninvasive measurement of glucose in a tissue of a subject, including the steps of bringing an adaptation device, which has a shape similar to a measurement probe, into contact with a skin part of a subject for stretching the skin part of the subject under a pressure that is higher than a pressure per unit area applied by the measurement probe during the noninvasive measurement, maintaining the contact for a predetermined period of time followed by relieving the contact, bringing the measurement probe into contact with the stretched skin part of the subject for the noninvasive measurement, collecting signals emitted from the subject, and estimating a glucose concentration based on the collected signals.Type: GrantFiled: April 6, 2009Date of Patent: November 20, 2012Assignee: Toshiba Medical Systems CorporationInventors: Shoichi Kanayama, Omar S. Khalil, Tzyy-Wen Jeng, Shu-Jen Yeh
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Publication number: 20120215457Abstract: Disclosed are example methods and systems to determine the quantity of an analyte initially present in a chemical and or biological reaction. Also disclosed are computer implemented methods and systems to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.Type: ApplicationFiled: January 13, 2012Publication date: August 23, 2012Inventors: ERIC B. SHAIN, John M. Clemens, Tzyy-Wen Jeng, George J. Schneider
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Patent number: 8099243Abstract: A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.Type: GrantFiled: August 11, 2008Date of Patent: January 17, 2012Assignee: Abbott LaboratoriesInventors: Eric B. Shain, John M. Clemens, Tzyy-Wen Jeng, George J. Schneider
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Patent number: 8005625Abstract: A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.Type: GrantFiled: August 11, 2008Date of Patent: August 23, 2011Assignee: Abbott Laboratories, Inc.Inventors: Eric B. Shain, John M. Clemens, Tzyy-Wen Jeng, George J. Schneider
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Publication number: 20100016689Abstract: A method for noninvasive measurement of glucose in a tissue of a subject, including the steps of bringing an adaptation device, which has a shape similar to a measurement probe, into contact with a skin part of a subject for stretching the skin part of the subject under a pressure that is higher than a pressure per unit area applied by the measurement probe during the noninvasive measurement, maintaining the contact for a predetermined period of time followed by relieving the contact, bringing the measurement probe into contact with the stretched skin part of the subject for the noninvasive measurement, collecting signals emitted from the subject, and estimating a glucose concentration based on the collected signals.Type: ApplicationFiled: April 6, 2009Publication date: January 21, 2010Inventors: Shoichi Kanayama, Omar S. KHALIL, Tzyy-Wen JENG, Shu-Jen YEH
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Patent number: 7565250Abstract: A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.Type: GrantFiled: November 17, 2004Date of Patent: July 21, 2009Assignee: Abbott Laboratories Inc.Inventors: Eric B. Shain, John M. Clemens, Tzyy-Wen Jeng, George J. Schneider
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Publication number: 20090047679Abstract: A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.Type: ApplicationFiled: August 11, 2008Publication date: February 19, 2009Applicant: Abbott LaboratoriesInventors: Eric B. Shain, John M. Clemens, Tzyy-Wen Jeng, George J. Schneider
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Publication number: 20080299583Abstract: A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.Type: ApplicationFiled: August 11, 2008Publication date: December 4, 2008Applicant: ABBOTT LABORATORIESInventors: Eric B. Shain, John M. Clemens, Tzyy-Wen Jeng, George J. Schneider
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Patent number: 7303922Abstract: Apparatus and method for determining at least one parameter, e. g., concentration, of at least one analyte, e. g., urea, of a biological sample, e. g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample.Type: GrantFiled: April 22, 2004Date of Patent: December 4, 2007Assignee: Abbott LaboratoriesInventors: Tzyy-Wen Jeng, Larry L. McDowell, Joseph Larry Pezzaniti, Gary M. Oosta, Eric B. Shain
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Patent number: 7043287Abstract: Devices and methods for non-invasively measuring at least one parameter of a sample, such as the presence of a disease condition, progression of a disease state, presence of an analyte, or concentration of an analyte, in a biological sample, such as, for example, a body part. In these devices and methods, temperature is controlled and is varied between preset boundaries. The methods and devices measure light that is reflected, scattered, absorbed, or emitted by the sample from an average sampling depth, dav, that is confined within a region in the sample wherein temperature is controlled. According to the method of this invention, the sampling depth dav, in human tissue is modified by changing the temperature of the tissue. The sampling depth increases as the temperature is lowered below the body core temperature and decreases when the temperature is raised within or above the body core temperature. Changing the temperature at the measurement site changes the light penetration depth in tissue and hence dav.Type: GrantFiled: October 15, 1999Date of Patent: May 9, 2006Assignee: Abbott LaboratoriesInventors: Omar S. Khalil, Shu-Jen Yeh, Xiaomao Wu, Stanislaw Kantor, Charles F. Hanna, Tzyy-Wen Jeng
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Publication number: 20050130211Abstract: A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.Type: ApplicationFiled: November 17, 2004Publication date: June 16, 2005Inventors: Eric Shain, John Clemens, Tzyy-Wen Jeng, George Schneider
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Publication number: 20040197927Abstract: Apparatus and method for determining at least one parameter, e. g., concentration, of at least one analyte, e. g., urea, of a biological sample, e. g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample.Type: ApplicationFiled: April 22, 2004Publication date: October 7, 2004Inventors: Tzyy-Wen Jeng, Larry L. McDowell, Joseph Larry Pezzaniti, Gary M. Oosta, Eric B. Shain
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Patent number: 6773922Abstract: Apparatus and method for determining at least one parameter, e.g., concentration, of at least one analyte, e.g., urea, of a biological sample, e.g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample.Type: GrantFiled: July 9, 2002Date of Patent: August 10, 2004Assignee: Abbott LaboratoriesInventors: Tzyy-Wen Jeng, Larry L. McDowell, Joseph Larry Pezzaniti, Gary M. Oosta, Eric B. Shain
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Patent number: 6662031Abstract: A method for the determination of hemoglobin and hematocrit by means of an apparatus that is capable of controlling the temperature of a defined subcutaneous volume of human skin. The method involves a calculation of hemoglobin concentration and hematocrit value that takes into consideration the values of optical parameters of the sample at various pre-set temperatures. The apparatus and method employ steady state optical measurements of samples, such as, for example, human tissue, by means of a reflectance tissue photometer and localized control of the temperature of the sample. According to the method of this invention, an optical signal from a defined subcutaneous volume of human skin is measured as the temperature of this volume is controlled. The method and apparatus of this invention allow determination of hemoglobin concentration and hematocrit value non-invasively in a population of subjects having different skin colors by means of steady state reflectance measurements.Type: GrantFiled: May 8, 2000Date of Patent: December 9, 2003Assignee: Abbott LaboratoiesInventors: Omar S. Khalil, Xiaomao Wu, Shu-jen Yeh, Charles F. Hanna, Stanislaw Kantor, Tzyy-Wen Jeng
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Patent number: 6654620Abstract: A method for determining the concentration of an analyte in a biological sample comprising the steps of: (1) providing an optical measuring instrument comprising a thermally controllable optical measuring element that comes into contact with the surface of the biological sample; (2) applying a coupling agent to the optical measuring element or to the surface of the biological sample or to both so that the coupling agent will be disposed at the interface of the surface of the biological sample and the optical measuring element; (3) measuring optical properties of the biological sample by means of the optical measuring instrument; and (4) correlating the optical properties of the biological sample with the concentration of the analyte in the biological sample. The coupling agent can be selected from the group consisting of silicone oil, mineral oil, polyethylene glycols, and oils from natural resources.Type: GrantFiled: April 16, 2001Date of Patent: November 25, 2003Assignee: Abbott LaboratoriesInventors: Xiaomao Wu, Omar S. Khalil, Tzyy-Wen Jeng, Shu-Jen Yeh, Charles F. Hanna
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Patent number: 6615061Abstract: A method and apparatus for the measurement of trans-cutaneous diffuse reflectance at a single sampling distance for determining the concentration of an analyte in a biological sample, such as, for example, human tissue. The determination of the concentration of the analyte has been found to depend on the sampling distance and reaches an optimal result at a defined sampling distance for a given analyte and a given sample. The method involves measuring the light re-emitted from the sample at a distance from a light introduction site and correlating the intensity of the re-emitted light to the concentration of an analyte. For a given sample, the distance between the light collection site and a light introduction site (i.e., the sampling distance) corresponds to the depth from the surface into the sample at which scattering and absorption events significantly affect the intensity of re-emitted light (i.e., the sampling depth).Type: GrantFiled: August 3, 1999Date of Patent: September 2, 2003Assignee: Abbott LaboratoriesInventors: Omar S. Khalil, Xiaomao Wu, Shu-jen Yeh, Charles F. Hanna, Stanislaw Kantor, Tzyy-Wen Jeng
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Publication number: 20030048432Abstract: Apparatus and method for determining at least one parameter, e.g., concentration, of at least one analyte, e.g., urea, of a biological sample, e.g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample.Type: ApplicationFiled: July 9, 2002Publication date: March 13, 2003Inventors: Tzyy-Wen Jeng, Larry L. McDowell, Joseph Larry Pezzaniti, Gary M. Oosta, Eric B. Shain
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Patent number: 6426045Abstract: Apparatus and method for determining at least one parameter, e. g., concentration, of at least one analyte, e. g., urea, of a biological sample, e. g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample.Type: GrantFiled: September 28, 1999Date of Patent: July 30, 2002Assignee: Abbott LaboratoriesInventors: Tzyy-Wen Jeng, Larry L. McDowell, Joseph Larry Pezzaniti, Gary M. Oosta, Eric B. Shain
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Publication number: 20020055671Abstract: A method for determining the concentration of an analyte in a biological sample comprising the steps of:Type: ApplicationFiled: April 16, 2001Publication date: May 9, 2002Inventors: Xiaomao Wu, Omar S. Khalil, Tzyy-Wen Jeng, Shu-Jen Yeh, Charles F. Hanna