Abstract: The present invention discloses pharmaceutical preparations for treatment of eye disorders containing an alpha 2 adrenergic agonist, to processes for producing the pharmaceutical preparations and methods for treatment of various eye disorders including dry eye and Meibomian gland dysfunction and a medicinal applicator for topical application of an alpha 2 adrenergic agonist to a subject, a package assembly for the medicinal applicator and methods of using the medicinal applicator to treat eye disorders.

Abstract: Methods and systems to regulate a voltage with multiple selectable voltage regulator (VR) modes, using multiple corresponding circuits and/or a configurable circuit. The circuit may be configurable for one or more of a power-gate VR mode, a switched-capacitor VR (SCVR) mode, and a linear mode, such as a low drop-out (LDO) VR mode. A feedback controller, such as a proportional-integral-derivative (PID) controller, may configure and/or control a multi-mode VR for a selected VR mode. The feedback controller may select a VR mode based on a reference voltage and voltage ranges associated with the VR modes. The circuit may be configurable as banks of VRs, and the controller may be implemented to transition between VR modes by switching sub-banks between modes until the transition is complete.

Abstract: Compositions and methods for targeted delivery of therapeutic agents, and particularly for mucosal, oral, nasal, or parenteral delivery of therapeutic agents. The compositions comprise carrier particles containing or encapsulating a therapeutic agent or agents, which have been modified on their surface to contain one or more targeting moieties that enable the enhanced uptake and transport of the therapeutic agent via receptor-mediated processes such as endocytosis or transcytosis.

Abstract: Described is an apparatus comprising: first and second processing cores; and a PCU which is operable to: generate a first VID for an off-die regulator external to the apparatus, the first VID resulting in a first power supply for the first processing core; and generate a second VID different from the first VID, the second VID resulting in a second power supply for the second processing core. Described is an apparatus comprising: a plurality of power-gate transistors controllable by a digital bus, the plurality of power-gate transistors operable to provide a first power supply to a processing core, and to receive a second power supply as input; an ADC to receive the first power supply and to generate a digital output representative of the first power supply; and a controller to receive the digital output representative and to generate the digital bus for controlling the plurality of power-gate transistors.

Abstract: Compositions and methods for targeted delivery of therapeutic agents, and particularly for mucosal, oral, nasal, or parenteral delivery of therapeutic agents. The compositions comprise carrier particles containing or encapsulating a therapeutic agent or agents, which have been modified on their surface to contain one or more targeting moieties that enable the enhanced uptake and transport of the therapeutic agent via receptor-mediated processes such as endocytosis or transcytosis.

Abstract: The present invention is a system and method for searching a large database of dig location tickets for tickets of particular interest. A user can locate an area of concern on an on-screen map and can view a list of tickets received for a given date range of the map. For example, when underground plant damage occurs in a particular region, users need not text-search in the database to locate a particular ticket that may have caused the damage, but can instead locate the ticket using the enhanced on-screen map of the invention.