Abstract: The present invention discloses apparatus and methods for a lightweight subsea intervention package. In one embodiment, the system comprises a lower riser package for controlling the subsea well which utilizes a plurality of hydraulically activated well barriers. An emergency disconnect package is secured to the lower riser package and is electrically connected to the lower riser package. The emergency disconnect package is operable to seal the bottom of a riser and minimize environmental leakage of fluid from the riser. The lower riser package and emergency disconnect package each contain a closed loop system of fluid operable to control the system without fluid from the surface. Each is operable to control the well barriers. Either an electrical connection or an acoustic control system may be utilized to control the system. The lower riser package can be operated from the surface when the emergency disconnect package has been disconnected.

Abstract: A locking mechanism for a subsea cutting/sealing device to seal a wellbore and cut any drill pipe in the wellbore. The subsea cutting/sealing device locks two pipe cutters in a closed position utilizing locking mechanisms on two position rods. The position rods are part of a visual indicator that an ROV camera or diver may use to determine whether the pipe cutter is closed or open position. The locking mechanism operates according to a sequence of operation for opening/closing the pipe cutters. An ROV tool can be used that is capable of operating the locking mechanism as well as opening and closing the subsea cutting sealing device.

Abstract: An intervention package for servicing a subsea well has an emergency disconnect package mountable to a riser and a lower riser package connectable to the subsea well. One or more compact cutting devices are utilized on the lower riser package. The intervention package can be used without a BOP. The compact cutting device has a throughbore going through the body that is connectable to the wellbore. Mounted in the body are two gates that are continuously in contact with each other. Each gate has a blank portion and an opening. For each gate, a piston and piston chamber are on the opposite side of gate from the bore that goes through the body.

Abstract: The present invention discloses apparatus and methods for a lightweight subsea intervention package. In one embodiment, the system comprises a lower riser package for controlling the subsea well which utilizes a plurality of hydraulically activated well barriers. An emergency disconnect package is secured to the lower riser package and is electrically connected to the lower riser package. The emergency disconnect package is operable to seal the bottom of a riser and minimize environmental leakage of fluid from the riser. The lower riser package and emergency disconnect package each contain a closed loop system of fluid operable to control the system without fluid from the surface. Each is operable to control the well barriers. Either an electrical connection or an acoustic control system may be utilized to control the system. The lower riser package can be operated from the surface when the emergency disconnect package has been disconnected.

Abstract: A subsea compact cutting system operable for cutting pipe utilizing two gates. Each gate preferably has a blanking portion and an opening through the gate. A first gate is moveable only between an open throughbore position and a partially open throughbore position. A second gate is moveable between an open throughbore position and a closed throughbore position. To cut pipe and seal off the throughbore, the first gate is moved to a position where a cutting element on the first gate is centrally located in the throughbore. The second gate moves to seal the throughbore. A cutting element on the second gate interacts with the cutting element on the first gate to cut pipe in the throughbore.

Abstract: As compared to a BOP, a compact lightweight cutting system may have two gates with cutters moveable in opposite directions to cut drill pipe. The system utilizes a relatively short stroke and relatively less hydraulic oil for subsea operation. The system utilizes two gates with flat surfaces for sealing with the two corresponding upper and lower seats. The compact cutting system with a gate valve can be used to substitute for a BOP to significantly reduce the size and weight required in an intervention system.

Abstract: A locking mechanism for a subsea cutting/sealing device to seal a wellbore and cut any drill pipe in the wellbore. The subsea cutting/sealing device locks two pipe cutters in a closed position utilizing locking mechanisms on two position rods. The position rods are part of a visual indicator that an ROV camera or diver may use to determine whether the pipe cutter is closed or open position. The locking mechanism operates according to a sequence of operation for opening/closing the pipe cutters. An ROV tool can be used that is capable of operating the locking mechanism as well as opening and closing the subsea cutting sealing device.

Abstract: An intervention package for servicing a subsea well has an emergency disconnect package mountable to a riser and a lower riser package connectable to the subsea well. One or more compact cutting device are utilized on the lower riser package. The intervention package can be used without a BOP to avoid the weight, size, and complexity of the BOP. The BOP requires maintenance after each cut, while the CCD does not, which is a major advantage for subsea projects. Due to decreased size and weight as compared to a BOP, the CCD can be easily transported and installed using less expensive methods, reducing overall time and costs for subsea projects.

Abstract: The present invention provides an improved process for the preparation of Ferric carboxymaltose (FCM) complex. In this process the oxidation of maltodextrins are carried out by using an organic hypo halite in the presence of a catalyst and a phase transfer catalyst and later complex formation with ferric salt or ferric hydroxide or iron hydroxide maltodextrin complex.

Abstract: A subsea compact cutting system operable for cutting pipe utilizing two gates. Each gate preferably has a blanking portion and an opening through the gate. A first gate is moveable only between an open throughbore position and a partially open throughbore position. A second gate is moveable between an open throughbore position and a closed throughbore position. To cut pipe and seal off the throughbore, the first gate is moved to a position where a cutting element on the first gate is centrally located in the throughbore. The second gate moves to seal the throughbore. A cutting element on the second gate interacts with the cutting element on the first gate to cut pipe in the throughbore.

Abstract: The present invention generally relates to solid forms of tyrosine kinase inhibitors, in particular combinations of tyrosine kinase inhibitors with anti-oxidative acids, processes for its preparation and a pharmaceutical compositions containing the same.

Abstract: As compared to a BOP, a compact lightweight cutting system may have two gates with cutters moveable in opposite directions to cut drill pipe. The system utilizes a relatively short stroke and relatively less hydraulic oil for subsea operation. The system utilizes two gates with flat surfaces for sealing with the two corresponding upper and lower seats. The compact cutting system with a gate valve can be used to substitute for a BOP to significantly reduce the size and weight required in an intervention system.

Abstract: As compared to a BOP, a compact lightweight cutting system may have two gates with cutters moveable in opposite directions to cut drill pipe. The system utilizes a relatively short stroke and relatively less hydraulic oil for subsea operation. An opening through the gates surrounds the wellbore in the open position. The cutting elements are mounted within the openings. The piston rods and pistons are vertically offset with respect to each other. The compact cutting system with a gate valve can be used to substitute for a BOP to significantly reduce the size and weight required in an intervention system.

Abstract: The present invention relates to process for the preparation of 7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R,5S)-dihydroxy-(E)-6-heptenoic acid calcium having formula (I). The compound of formula (I) has adopted name “Rosuvastatin Calcium”. The present invention is also related to novel intermediates of formula (4) and formula (5) used in preparation of formula (I), and process of their preparation.

Abstract: The present invention relates to process for the preparation of 7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R,5S)-dihydroxy-(E)-6-heptenoic acid calcium having formula (I). The compound of formula (I) has adopted name “Rosuvastatin Calcium”. The present invention is also related to novel intermediates of formula (4) and formula (5) used in preparation of formula (I), and process of their preparation.

Abstract: As compared to a BOP, a compact lightweight cutting system comprises two gates with cutters moveable in opposite directions to cut drill pipe. In one embodiment, the system comprises a relatively short stroke and utilizes relatively less hydraulic oil for subsea operation. In one embodiment, an opening through the gates surrounds the wellbore in the open position. The cutting elements are mounted within the openings. The piston rods and pistons are vertically offset with respect to each other. The compact cutting system with a gate valve can be used to substitute for a BOP to significantly reduce the size and weight required in an intervention system.

Abstract: The present invention generally relates to solid forms of tyrosine kinase inhibitors, in particular combinations of tyrosine kinase inhibitors with anti-oxidative acids, processes for its preparation and a pharmaceutical compositions containing the same.

Abstract: The invention relates to an improved process for the preparation of Losartan. The process comprising reacting 2-n-butyl-4-chloro-5-formyl imidazole with 2-(4-bromomethyl) benzonitrile in the presence of a phase transfer catalyst and an alkali, and reducing the resulting cyano aldehyde to produce a cyano alcohol which is further reacted with sodium azide in N-methyl pyrrolidinone and a salt to produce Losartan.

Abstract: The invention relates to a improved process for the preparation of Losartan and its potassium salt, which comprises: (i) reacting bromo OTBN with BCFI in the presence of a base and a phase transfer catalyst to produce a cyano aldehyde; reacting the formed cyano aldehyde with sodium azide in the presence of tributyl tin chloride to produce aldehyde tetrazole; reducing the formed aldehyde tetrazole with sodium borohydride to produce Losartan; and, if desired, converting the formed Losartan to its potassium salt by known method.

Abstract: The invention relates to an improved process for the preparation of Losartan. The process comprising reacting 2-n-butyl-4-chloro-5-formyl imidazole with 2-(4-bromomethyl) benzonitrile in the presence of a phase transfer catalyst and an alkali, and reducing the resulting cyano aldehyde to produce a cyano alcohol which is further reacted with sodium azide in N-methyl pyrrolidinone and a salt to produce Losartan.