Patents by Inventor Udo F. Axen
Udo F. Axen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4212986Abstract: 2,2-Difluoro prostaglandin E, F.sub..alpha., F.sub..beta., A, and B analogs are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they have two fluoro atoms at the C-2 position in place of the two hydrogen atoms at C-2 in the prostaglandins. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.Type: GrantFiled: September 17, 1976Date of Patent: July 15, 1980Assignee: The Upjohn CompanyInventor: Udo F. Axen
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Patent number: 4209637Abstract: 2,2-Difluoro prostaglandin E, F.sub..alpha., F.sub..beta., A, and B analogs are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they have two fluoro atoms at the C-2 position in place of the two hydrogen atoms at C-2 in the prostaglandins. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.Type: GrantFiled: September 17, 1976Date of Patent: June 24, 1980Assignee: The Upjohn CompanyInventor: Udo F. Axen
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Patent number: 4207420Abstract: 2,2-Difluoro prostanglandin E, F.sub..alpha., F.sub..beta., A, and B analogs are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they have two fluoro atoms at the C-2 position in place of the two hydrogen atoms at C-2 in the prostaglandins. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.Type: GrantFiled: September 17, 1976Date of Patent: June 10, 1980Assignee: The Upjohn CompanyInventor: Udo F. Axen
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Patent number: 4205178Abstract: Prostaglandin E (PGE)-type derivatives and analogs having a 6-keto feature are disclosed, including processes for preparing them and the appropriate intermediates, said derivatives having pharmacological activity.A typical 6-keto compound is 6-keto-PGE.sub.Type: GrantFiled: September 2, 1977Date of Patent: May 27, 1980Assignee: The Upjohn CompanyInventor: Udo F. Axen
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Patent number: 4197257Abstract: Prostaglandin (PG.sub.1) derivatives having (1) a 6-keto feature, for example ##STR1## and amides thereof or (2) a 9-deoxy-6,9-epoxy feature together with a 5-halo or 6-hydroxy feature, for example ##STR2## said derivatives having pharmacological activity. Processes for preparing them and the appropriate intermediates are disclosed.Type: GrantFiled: November 9, 1978Date of Patent: April 8, 1980Assignee: The Upjohn CompanyInventor: Udo F. Axen
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Patent number: 4191824Abstract: Prostaglandin (PG.sub.1) derivatives having (1) a 6-keto feature, for example ##STR1## or (2) a 9-deoxy-6,9-epoxy feature together with a 5-halo or 6-hydroxy feature, for example ##STR2## said derivatives having pharmacological activity. Processes for preparing them and the appropriate intermediates are disclosed.Type: GrantFiled: November 9, 1978Date of Patent: March 4, 1980Assignee: The Upjohn CompanyInventor: Udo F. Axen
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Patent number: 4187224Abstract: 2-Decarboxy-2-hydroxymethyl-5,6-dihydro-prostacyclin analogs (PGI.sub.1 derivatives) illustrated by a compound of the formula ##STR1## wherein .about. indicates alpha or beta configuration, and the processes for producing them, said analogs having pharmacological utility.Type: GrantFiled: June 19, 1978Date of Patent: February 5, 1980Assignee: The Upjohn CompanyInventor: Udo F. Axen
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Patent number: 4170598Abstract: Mercury derivatives of 5,6-dihydroprostacyclins are disclosed, illustrated for example by ##STR1## wherein G is nitrato, iodo, chloro, bromo, acetato, trifluoroacetato, or benzoato, and wherein .about. indicates alpha or beta configuration, said products having pharmacological activity.Type: GrantFiled: June 19, 1978Date of Patent: October 9, 1979Assignee: The Upjohn CompanyInventor: Udo F. Axen
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Patent number: 4158667Abstract: Prostaglandin (PG.sub.1) derivatives having (1) a 6-keto feature, for example ##STR1## or (2) a 9-deoxy-6,9-epoxy feature together with a 5-halo or 6-hydroxy feature, for example ##STR2## said derivatives having pharmacological activity. Processes for preparing them and the appropriate intermediates are disclosed.Type: GrantFiled: July 28, 1977Date of Patent: June 19, 1979Assignee: The Upjohn CompanyInventor: Udo F. Axen
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Patent number: 4125712Abstract: Processes for preparing 5,6-dihydro-prostacyclin analogs, which are 9-deoxy-6,9-cyclic ethers of prostaglandin F.sub.1.alpha. -type compounds, illustrated for example, by a compound of the formula ##STR1## wherein .about. indicates alpha or beta configuration; including the products and intermediates produced therein, said products having pharmacological utility.There are also provided mercury derivatives of these 5,6-dihydro-prostacyclins, illustrated, for example, by a compound of the formula ##STR2## wherein G is nitrato, iodo, chloro, bromo, acetato, trifluoroacetato, or benzoato, and wherein .about. indicates alpha or beta configuration, said products having pharmacological activity, and useful as intermediates in preparing the above compounds.Type: GrantFiled: December 5, 1977Date of Patent: November 14, 1978Assignee: The Upjohn CompanyInventor: Udo F. Axen
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Patent number: 4097519Abstract: 2,2-Difluoro prostaglandin E, F.sub..alpha., F.sub..beta., A and B analogs are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they have two fluoro atoms at the C-2 position in place of the two hydrogen atoms at C-2 in the prostaglandins. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.Type: GrantFiled: September 17, 1976Date of Patent: June 27, 1978Assignee: The Upjohn CompanyInventor: Udo F. Axen
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Patent number: 4073803Abstract: 2,2-Difluoro prostaglandin E, F.sub..alpha., F.sub..beta., A, and B analog are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they have two fluoro atoms at the C-2 position in place of the two hydrogen atoms at C-2 in the prostaglandins. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.Type: GrantFiled: September 17, 1976Date of Patent: February 14, 1978Assignee: The Upjohn CompanyInventor: Udo F. Axen
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Patent number: 4068083Abstract: 2,2-Difluoro prostaglandin E, F.sub..alpha., F.sub..beta., A, and B analogs are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they have two fluoro atoms at the C-2 position in place of the two hydrogen atoms at C-2 in the prostaglandins. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.Type: GrantFiled: September 17, 1976Date of Patent: January 10, 1978Assignee: The Upjohn CompanyInventor: Udo F. Axen
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Patent number: 4065633Abstract: 2,2-Difluoro prostaglandin E, F.sub..alpha., F.sub..beta., A, and B analogs are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they have two fluoro atoms at the C-2 position in place of the two hydrogen atoms at C-2 in the prostaglandins. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.Type: GrantFiled: September 17, 1976Date of Patent: December 27, 1977Assignee: The Upjohn CompanyInventor: Udo F. Axen
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Patent number: 4064160Abstract: 2,2-Difluoro prostaglandin E, F.sub..alpha., F.sub..beta., A, and B analog are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they have two fluoro atoms at the C-2 position in place of the two hydrogen atoms at C-2 in the prostaglandins. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.Type: GrantFiled: September 17, 1976Date of Patent: December 20, 1977Assignee: The Upjohn CompanyInventor: Udo F. Axen
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Patent number: 4061866Abstract: 2,2-Difluoro prostaglandin E, F.sub..alpha., F.sub..beta., A, and B analogs are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they have two fluoro atoms at the C-2 position in place of the two hydrogen atoms at C-2 in the prostaglandins. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.Type: GrantFiled: September 17, 1976Date of Patent: December 6, 1977Assignee: The Upjohn CompanyInventor: Udo F. Axen
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Patent number: 4059614Abstract: 2,2-Difluoro prostaglandin E, F.sub..alpha., F.sub..beta., A, and B analogs are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they have two fluoro atoms at the C-2 position in place of the two hydrogen atoms at C-2 in the prostaglandins. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.Type: GrantFiled: September 17, 1976Date of Patent: November 22, 1977Assignee: The Upjohn CompanyInventor: Udo F. Axen
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Patent number: 4057574Abstract: 2,2-Difluoro prostaglandin E, F.sub..alpha., F.sub..beta., A and B analog are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they have two fluoro atoms at the C-2 position in place of the two hydrogen atoms at C-2 in the prostaglandins. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.Type: GrantFiled: September 17, 1976Date of Patent: November 8, 1977Assignee: The Upjohn CompanyInventor: Udo F. Axen
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Patent number: 4056556Abstract: 2,2-Difluoro prostaglandin E, F.sub..alpha., F.sub..beta., A, and B analog are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they have two fluoro atoms at the C-2 position in place of the two hydrogen atoms at C-2 in the prostaglandins. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.Type: GrantFiled: September 17, 1976Date of Patent: November 1, 1977Assignee: The Upjohn CompanyInventor: Udo F. Axen
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Patent number: 4056555Abstract: 2,2-Difluoro prostaglandin E, F.sub..alpha., F.sub..beta., A, and B analogs are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they have two fluoro atoms at the C-2 position in place of the two hydrogen atoms at C-2 in the prostaglandins. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.Type: GrantFiled: September 17, 1976Date of Patent: November 1, 1977Assignee: The Upjohn CompanyInventor: Udo F. Axen