Patents by Inventor Udo Gräfe

Udo Gräfe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HKI10311129, novel antibiotic, method for producing the same and the use thereof
    Patent number: 7557091
    Abstract: The invention relates to the novel antibiotic HKI10311129 which has a molecular weight of 1113 and the summation formula C56H75NO22. The invention also relates to a method for producing said antibiotic using the microorganism Streptomyces spec. DSM 13059, and to the use thereof as an antibacterial substance which is especially effective against infections with Gram positive bacteria, especially antibiotic-resistant germs.
    Type: Grant
    Filed: February 2, 2005
    Date of Patent: July 7, 2009
    Assignee: Leibniz-Institut fuer Naturstoff-Forschung und Infektionsbiologie e.V. Hans-Knoell-Institut
    Inventors: Ute Moellmann, Kerstin Herold, Martin Roth, Ingrid Groth, Friedrich Gollmick, Karin Brigitte Charlotte Graefe, legal representative, Andrea Graefe, legal representative, Susanna Graefe, legal representative, Udo Graefe
  • Method for treating neurological conditions and inducing immunosuppression with cephaibols
    Patent number: 7041649
    Abstract: Embodiments of the present invention relate to administering cephaibols to treat conditions of the nervous system and to treat those conditions in which suppressing the immune system would have beneficial effect.
    Type: Grant
    Filed: May 21, 2003
    Date of Patent: May 9, 2006
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Mathias Schiell, Laszio Vertesy, Joachim Wink, Brigitte Schlegel, Albert Haertl, Udo Graefe
  • Method for treating neurological conditions and inducing immunosuppression with cephaibols
    Publication number: 20040023886
    Abstract: Embodiments of the present invention relate to administering cephaibols to treat conditions of the nervous system and to treat those conditions in which suppressing the immune system would have beneficial effect.
    Type: Application
    Filed: May 21, 2003
    Publication date: February 5, 2004
    Applicant: Aventis Pharma Deutschland Gmbh
    Inventors: Mathias Schiell, Laszio Vertesy, Joachim Wink, Brigitte Schlegel, Albert Haertl, Udo Graefe
  • Use of maduraohtalazine derivatives as inhibitors of proinflammatory cytokines
    Patent number: 6440968
    Abstract: The maduraphthalazine derivatives of the formula (4) are able to inhibit the effect of the cytokines interleukin-2, interleukin-4 and interleukin-5 and are suitable for the production of pharmaceuticals.
    Type: Grant
    Filed: April 13, 2000
    Date of Patent: August 27, 2002
    Assignee: Elbion G.m.b.H.
    Inventors: Regina Draheim, Thomas Kronbach, Lothar Heinisch, Ernst Roemer, Norbert Höfgen, Hildegard Poppe, Peter Jütten, Wolfgang Haas, Walter Werner, Udo Gräfe
  • Polycyclic phthalazine compounds and their use
    Patent number: 6124290
    Abstract: Polycyclic phthalazines, in particular 2-substituted maduraphthalazines (10,12,15,16-tetrahydroxy-8-methoxy-11-methyl-1,9,14-trioxo-1,2,6,7,9,14-h exahydronaphthaceno-1,2-g-phthalazines), of formula I and their use against gram-positive bacterial strains, particularly against multi-resistant staphylococci (MRSA) and against glycopeptide-resistant, for example vancomycin-resistant, enterococci. The polycyclic phthalazines are thus suitable for preparing anti-bacterially effective pharmaceutical compositions. In formula I, R.sup.1 is carboxyalkyl or carboxyaryl, and R.sup.2 and R.sup.3 represent H or acyl (for example CO-alkyl or COO-alkyl), with R.sup.1 being different from optionally substituted carboxyphenyl when R.sup.3 represents C.sub.1-8 alkanoyl. The invention also relates to salts, amides and esters of compounds of formula I.
    Type: Grant
    Filed: January 28, 2000
    Date of Patent: September 26, 2000
    Assignee: Gruenenthal GmbH
    Inventors: Lothar Heinisch, Ute Moellmann, Wolfgang Witte, Christiane Cuny, Ernst Roemer, Walter Werner, Udo Graefe