Patents by Inventor Ugo Pradere

Ugo Pradere has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PURINE MONOPHOSPHATE PRODRUGS FOR TREATMENT OF VIRAL INFECTIONS
    Publication number: 20140212382
    Abstract: The present invention is directed to compounds, compositions and methods for treating or preventing viral infections using nucleoside analog monophosphate prodrugs. More specifically, HCV, Norovirus, Saporovirus, Dengue virus, Chikungunya virus and Yellow fever in human patients or other animal hosts. The compounds are certain 2,6-diamino 2-C-methyl purine nucleoside monophosphate prodrugs and modified prodrug analogs, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HCV, Norovirus, Saporovirus, Dengue virus, Chikungunya virus and Yellow fever. This invention teaches how to modify the metabolic pathway of 2,6-diamino 2?-C-methyl purine and deliver nucleotide triphosphate(s) to polymerases at heretofore unobtainable therapeutically-relevant concentrations.
    Type: Application
    Filed: May 16, 2012
    Publication date: July 31, 2014
    Applicants: EMORY UNIVERSITY, RFS PHARMA, LLC
    Inventors: Raymond F. Schinazi, Jong Hyun Cho, Longhu Zhou, Hongwang Zhang, Ugo Pradere, Steven J. Coats
  • Phosphonates synthons for the synthesis of phosphonates derivatives showing better bioavailability
    Patent number: 8785629
    Abstract: Synthons for the synthesis of phosphonates prodrugs POM and POC, especially for direct Cross Metathesis.
    Type: Grant
    Filed: June 17, 2010
    Date of Patent: July 22, 2014
    Assignees: Centre National de la Recherche Scientifique, Universite d'Orleans
    Inventors: Luigi A. Agrofoglio, Vincent Roy, Ugo Pradere
  • PHOSPHONATES SYNTHONS FOR THE SYNTHESIS OF PHOSPHONATES DERIVATIVES SHOWING BETTER BIOAVAILABILITY
    Publication number: 20120142897
    Abstract: Synthons for the synthesis of phosphonates prodrugs POM and POC, especially for direct Cross Metathesis.
    Type: Application
    Filed: June 17, 2010
    Publication date: June 7, 2012
    Applicants: UNIVERSITE D'ORLEANS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Luigi A. Agrofoglio, Vincent Roy, Ugo Pradere