Patents by Inventor Uisuk JEONG

Uisuk JEONG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NEW SMALL-MOLECULE COMPOUNDS FOR CONTROLLING ENDOSOMAL TOLL-LIKE RECEPTORS AND THERAPEUTIC AGENT FOR AUTOIMMUNE DISEASES USING SAME
    Publication number: 20240018139
    Abstract: Antagonistic small-molecule compounds having a function of inhibiting endosomal Toll-like receptors (TLRs), more specifically, a small-molecule compound for inhibiting TLR3/7/8/9 signaling pathways, a composition for inhibiting Toll-like receptors, containing the compound; and a composition for preventing or treating autoimmune diseases, inflammatory diseases, or viral diseases are disclosed. The novel compound shows very significant results in a systemic lupus erythematosus animal model by not only preventing TNF-? secretion induced by poly I:C (TLR3 agonist), imiquimod (TLR7 agonist), TL8-506 (TLR8 agonist), or ODN2395 (TLR9 agonist), but also inhibiting the production of inflammatory cytokines. This suggests that the compound is also useful for the prevention or treatment of TLR3, TLR7, TLR8 or TLR9-associated autoimmune diseases, inflammatory diseases and viral diseases.
    Type: Application
    Filed: November 25, 2021
    Publication date: January 18, 2024
    Applicant: S&K THERAPEUTICS
    Inventors: Sangdun CHOI, Chang Hee SUH, Uisuk JEONG, Yangseon CHOI, Wook-Young BAEK, Kevin Jaesuk CHOI, Chun Yong IM, Doohyun LEE, Nam Hui KIM, Seungyeon LEE, Hyo-Ji KIM, Sang Kyoon KIM, Yoojin OH, So Young KIM, Ye Ri HAN