Abstract: The present disclosure provides compositions comprising a thermosensitive hydrogel formulation of funapide and a tri-block polymer, and methods of use and manufacture of the compositions for management of acute pain or pain associated with surgical procedure.

Abstract: An artificial intelligence (AI)-based system and method for autonomous navigation of robotic devices in dynamic human-centric environments are disclosed. The AI-based system comprises an object tracking subsystem, a probabilistic estimation subsystem, a socially compliant behavior subsystem, a constrained space navigation subsystem, a commands processing subsystem, a virtual cost-map layer subsystem, and a path-planning subsystem. The AI-based system obtains sensor data using sensors. The AI-based system employs artificial intelligence (AI) models and machine learning (ML) models for computing probabilistic position data and generating convex hulls. The AI-based system generates high-cost zones for identifying boundaries associated with groups to plan navigation paths. The AI-based system generates waypoints for the robotic devices based on detecting constrained spaces in the dynamic human-centric environments by analyzing the sensor data.

Abstract: The present disclosure provides compositions comprising a thermosensitive hydrogel formulation of anesthetic drugs and a triblock copolymer component, and methods of use and manufacture of the compositions for management of acute pain or pain associated with surgical procedure.

Abstract: The present disclosure provides compositions comprising a thermosensitive hydrogel formulation of funapide and a tri-block polymer, and methods of use and manufacture of the compositions for management of acute pain or pain associated with surgical procedure.

Abstract: This disclosure relates to extended-release fluticasone propionate (FP) formulations that include small microparticles and/or nanoparticles and methods of using these extended-release FP formulations for treating pain and/or inflammation in a subject.

Abstract: The present disclosure generally relates to lyophilized pharmaceutical compositions comprising polymeric nanoparticles which, upon reconstitution, have low levels of greater than 10 micron size particles. Other aspects of the invention include methods of making such nanoparticles.

Abstract: The present disclosure generally relates to nanoparticles comprising an endo-lysosomal escape agent, a nucleic acid, and a polymer. Other aspects include methods of making and using such nanoparticles.

Abstract: Embodiments of the present invention feature methods for screening parenteral formulations which require small quantities of drug and rapid results. The method features steps of identifying one or more solutions for reconstitution and applying the solutions to lyophilized drug, excipient and diluent combinations.