Abstract: The application is directed to a mesh nebulizer and related system including a dosing unit for providing a predetermined amount of a therapeutic agent, wherein the therapeutic agent is delivered in a portion container to be opened by pressure. The dosing unit comprises an uptake chamber with a dosing opening for dispensing the therapeutic agent, an opening for inserting a portion container and a locking body for the opening. The locking body is adapted to be moved from an open position in which the locking body releases the opening to a closed position in which the locking body closes the opening. The locking body is further adapted to be moved from the closed position to a drainage position in which the locking body applies pressure to the portion container to open the portion container and release the therapeutic agent.

Abstract: The invention relates to a nebulizer (1) comprising an aerosol generator (6), a nebulizing chamber (5) and an outlet (16), the aerosol generator (6) being designed to release an aerosol into the nebulizing chamber (5) and the outlet (16) being designed to allow the removal of the aerosol from the nebulizing chamber (5). To achieve a high output rate, a wetting surface (2) is provided in the nebulizing chamber (5).

Abstract: The invention relates to a nebulizer comprising an aerosol generator, a nebulizing chamber and an outlet, the aerosol generator being designed to release an aerosol into the nebulizing chamber and the outlet being designed to allow the removal of the aerosol from the nebulizing chamber. To achieve a high output rate, a wetting surface is provided in the nebulizing chamber.

Abstract: A valve (1, 11, 19) for an inhalation device comprising an interior volume that is delimited at least partially by a valve wall (4, 17, 21), a permanent opening (29) as well as a valve functional area (6), whereby the valve functional area (6) is configured to be at least almost closed below an opening pressure difference and to be open above an opening pressure difference such that above the opening pressure difference, a fluid can flow through the permanent opening (29) into the interior volume and out of the valve functional area (6), the valve comprising an inversion protector that is configured to impede or prevent inversion of the valve wall (4, 17, 21).

Abstract: A valve (1, 11, 19) for an inhalation device comprising an interior volume that is delimited at least partially by a valve wall (4, 17, 21), a permanent opening (29) as well as a valve functional area (6), whereby the valve functional area (6) is configured to be at least almost closed below an opening pressure difference and to be open above an opening pressure difference such that above the opening pressure difference, a fluid can flow through the permanent opening (29) into the interior volume and out of the valve functional area (6), the valve comprising an inversion protector that is configured to impede or prevent inversion of the valve wall (4, 17, 21).

Abstract: The invention relates to a nebulizer (1) comprising an aerosol generator (6), a nebulizing chamber (5) and an outlet (16), the aerosol generator (6) being designed to release an aerosol into the nebulizing chamber (5) and the outlet (16) being designed to allow the removal of the aerosol from the nebulizing chamber (5). To achieve a high output rate, a wetting surface (2) is provided in the nebulizing chamber (5).

Abstract: An inventive flanged graft for end-to-side anastomosis includes a tubular graft member and a flanged section The type and size of the flanged section is determined by various factors such as identity of the receiving artery, position of the arteriotomy on the receiving artery, and luminal diameter of the graft. The graft is preferably anastomosed to the receiving artery using continuous sutures to join the arteriotomy to the peripheral edges flanged section.

Abstract: A medical device which defines a lumen for flowing a bodily fluid from an upstream end of the device to a downstream end thereof is disclosed. The device has a luminal wall (14) that extends between the upstream and downstream ends and defines the lumen within which the fluid flows. The wall exhibits a succession of protuberances spaced from each other along the length of the device. Each protuberance has a flank facing upstream (54) and a flank facing downstream (64), the flank facing upstream extending into the fluid flow so that a radially outermost part of the flow of fluid from the upstream to the downstream end of the device impinges on the upstream flank and is thereby caused to reverse its flow, and flow upstream from the upstream flank to the downstream flank of the next adjacent protuberance upstream, creating micro-vortices between two adjacent protuberances.

Abstract: A medical device which defines a lumen for flowing a bodily fluid from an upstream end of the device to a downstream end thereof is disclosed. The device has a luminal wall (14) that extends between the upstream and downstream ends and defines the lumen within which the fluid flows. The wall exhibits a succession of protuberances spaced from each other along the length of the device. Each protuberance has a flank facing upstream (54) and a flank facing downstream (64), the flank facing upstream extending into the fluid flow so that a radially outermost part of the flow of fluid from the upstream to the downstream end of the device impinges on the upstream flank and is thereby caused to reverse its flow, and flow upstream from the upstream flank to the downstream flank of the next adjacent protuberance upstream, creating micro-vortices between two adjacent protuberances.

Abstract: An inventive flanged graft for end-to-side anastomosis includes a tubular graft member and a flanged section The type and size of the flanged section is determined by various factors such as identity of the receiving artery, position of the arteriotomy on the receiving artery, and luminal diameter of the graft. The graft is preferably anastomosed to the receiving artery using continuous sutures to join the arteriotomy to the peripheral edges flanged section.

Abstract: A medical device which defines a lumen for flowing a bodily fluid from an upstream end of the device to a downstream end thereof is disclosed. The device has a luminal wall (14) that extends between the upstream and downstream ends and defines the lumen within which the fluid flows. The wall exhibits a succession of protuberances spaced from each other along the length of the device. Each protuberance has a flank facing upstream (54) and a flank facing downstream (64), the flank facing upstream extending into the fluid flow so that a radially outermost part of the flow of fluid from the upstream to the downstream end of the device impinges on the upstream flank and is thereby caused to reverse its flow, and flow upstream from the upstream flank to the downstream flank of the next adjacent protuberance upstream, creating micro-vortices between two adjacent protuberances.

Abstract: An inventive flanged graft for end-to-side anastomosis includes a tubular graft member and a flanged section The type and size of the flanged section is determined by various factors such as identity of the receiving artery, position of the arteriotomy on the receiving artery, and luminal diameter of the graft. The graft is preferably anastomosed to the receiving artery using continuous sutures to join the arteriotomy to the peripheral edges flanged section.

Abstract: An inventive flanged graft for end-to-side anastomosis includes a tubular graft member and a flanged section The type and size of the flanged section is determined by various factors such as identity of the receiving artery, position of the arteriotomy on the receiving artery, and luminal diameter of the graft. The graft is preferably anastomosed to the receiving artery using continuous sutures to join the arteriotomy to the peripheral edges flanged section.

Abstract: An inventive flanged graft for end-to-side anastomosis includes a graft with bifurcated flanges. The bifurcated flanges may be symmetrical or asymmetrical relative to one another. The type and size of flange to be used is determined by various factors such as identity of the receiving artery, position of the arteriotomy on the receiving artery, and lumenal diameter of the graft. The graft is preferably anastomosed to the receiving artery using continuous sutures to join the arteriotomy to the peripheral edges of the bifucated flanges. In an alternate embodiment, the inventive bypass graft includes a flared skirt which extends circumferentially about the tubular graft member. The flared skirt has an elliptical shape and is offset from a central longitudinal axis of the graft member.

Abstract: An inventive flanged graft for end-to-side anastomosis includes a graft with bifurcated flanges. The bifurcated flanges may be symmetrical or asymmetrical relative to one another. The type and size of flange to be used is determined by various factors such as identity of the receiving artery, position of the arteriotomy on the receiving artery, and lumenal diameter of the graft. The graft is preferably anastomosed to the receiving artery using continuous sutures to join the arteriotomy to the peripheral edges of the bifucated flanges. In an alternate embodiment, the inventive bypass graft includes a flared skirt which extends circumferentially about the tubular graft member. The flared skirt has an elliptical shape and is offset from a central longitudinal axis of the graft member.

Abstract: An expanded polytetrafluoroethylene flanged vascular graft (10) suitable for end-to-side anastomosis grafting having an integral terminal polytetrafluoroethylene flanged skirt or cuff section (12) which facilitates an end-to-side anastomosis directly between an artery and the expanded polytetrafluoroethylene flanged bypass graft (10) without need for an intervening venous collar or venous patch.