Abstract: An embodiment of the present invention relates to a compound of the general formula. The compound of formula is suitable for use in a method for treating a disorder relating to the binding of a galectin, such as galectin-3 to a ligand in a mammal, such as a human. Furthermore an embodiment of the present invention concerns a method for treatment of a disorder relating to the binding of a galectin, such as galectin-3 to a ligand in a mammal, such as a human.

Abstract: A D-galactopyranose compound of formula (1) wherein the pyranose ring is beta-D-galactopyranose, and these compounds are high affinity galectin-1 and/or 3 inhibitors for use in treatment of inflammation; fibrosis; scarring; keloid formation; aberrant scar formation; surgical adhesions; scleroderma; systemic sclerosis; septic shock; cancer; metastasising cancers; autoimmune diseases; metabolic disorders; heart disease; heart failure; aortic stenosis; atherosclerosis; pathological angiogenesis; eye diseases; metabolic diseases; insulin resistance; obesity; Diastolic HF; asthma; otosclerosis; mesothelioma; liver disorders Liver cancer; cholangiocarcinoma; biliary tract cancer; and neurodegenerative disorders.

Abstract: The present invention relates to a semiconductive composition comprising (A) at least 52.0 wt %, preferably from 55.0 to 90.0 wt %, more preferably from 60.0 to 85.0 wt %, most preferably from 65.0 to 80.0 wt % of a heterophasic propylene copolymer having a matrix phase and an elastomeric phase dispersed in said matrix phase, based on the total weight amount of the semiconductive composition; and (B) from 5.0 to 40.0 wt %, preferably from 10.0 to 38.0 wt %, more preferably from 15.0 to 35.0 wt %, most preferably from 20.0 to 33.0 wt % of carbon black based on the total weight amount of the semiconductive composition, an article comprising said semiconductive composition, preferably a cable comprising an semiconductive layer comprising said semiconductive composition and the use of said semiconductive composition as inner and/or outer semiconductive layer for medium and high voltage cables.

Abstract: Use of a cable, e.g. to carry power, in a salt water environment, e.g. in the sea or under the sea; said cable comprising a conductor which is surrounded by at least an inner semiconductive layer, an insulation layer and an outer semi conductive layer in that order; wherein said insulation layer comprises (i) at least 60 wt % of a low density polyethylene homo or low density polyethylene copolymer with at least one polyunsaturated comonomer and optionally one or more further comonomers; and, (ii) 10 to 35 wt % of a low density polyethylene copolymer of ethylene and at least one polar comonomer selected from the group consisting of an alkyl acrylate, an alkyl methacrylate or vinyl acetate.

Abstract: A crosslinkable and crosslinked polymer composition containing a low density polyethylene (LDPE) homopolymer or low density polyethylene (LDPE) copolymer has excellent direct current (DC) electrical properties. The crosslinked polymer composition has an electrical conductivity of 150 fS/m or less, when measured at 70° C. and a 30 kV/mm mean electric field from a non-degassed, 1 mm thick plaque sample of the crosslinked polymer composition when measured according to a direct current (DC) conductivity method. A cable can be surrounded by at least one layer of the polymer composition.

Abstract: The present disclosure relates to a device for sonicating a biological sample. In one embodiment, a sample tube holder is pivotally suspended in a mount of a sonication device, thus allowing for a rotational degree of freedom and/or lateral movement that provides an optimized contact area between the sonotrode and the sample tube. Also disclosed is a method for sonicating a biological sample using the device described herein.

Abstract: The present disclosure relates to a device for sonicating a biological sample. In one embodiment, a sample tube holder is pivotally suspended in a mount of a sonication device, thus allowing for a rotational degree of freedom and/or lateral movement that provides an optimized contact area between the sonotrode and the sample tube. Also disclosed is a method for sonicating a biological sample using the device described herein.

Abstract: A process for preparing a compound of formula (X) The process includes reacting a compound of formula (IX) with an acetylating agent in the presence of a base in a suitable solvent and at a suitable temperature for a sufficient reaction time for preparing the compound of formula X. The process is suitable for large scale synthesis.

Abstract: The present disclosure relates to a thermal management system for a vehicle including a refrigerant system, a coolant system and a control unit. The coolant system includes a first control loop thermally coupled to an energy storage system, a second control loop thermally coupled to a drive train system, a third control loop thermally coupled to a radiator system, a first multiple valve unit and a second multiple valve unit, and a first heat exchanger configured to transfer heat to the refrigerant system. The first control loop, the second control loop and the third control loop are configured to transfer heat to the first heat exchanger. The first heat exchanger is arranged between the first multiple valve unit and the second multiple valve unit.

Abstract: An embodiment of the present invention relates to a compound of the general formula. The compound of formula is suitable for use in a method for treating a disorder relating to the binding of a galectin, such as galectin-3 to a ligand in a mammal, such as a human. Furthermore an embodiment of the present invention concerns a method for treatment of a disorder relating to the binding of a galectin, such as galectin-3 to a ligand in a mammal, such as a human.

Abstract: The present invention relates to a process for preparing a compound of formula (I) wherein said process is suitable for large scale synthesis.

Abstract: A polymer composition includes a crosslinked polyolefin with improved DC electrical properties. Prior to crosslinking, the polymer composition includes a polyolefin and peroxide, in which the peroxide is in an amount of less than 35 mmol —O—O— per kilogram of the polymer composition. A cable can be surrounded by at least one layer including the polymer composition.

Abstract: An embodiment of the present invention relates to a compound of the general formula. The compound of formula is suitable for use in a method for treating a disorder relating to the binding of a galectin, such as galectin-3 to a ligand in a mammal, such as a human. Furthermore an embodiment of the present invention concerns a method for treatment of a disorder relating to the binding of a galectin, such as galectin-3 to a ligand in a mammal, such as a human.

Abstract: The invention relates to polymer composition comprising a polyolefin (a) and an inorganic filler (b) wherein the polyolefin (a) is obtainable by a high pressure process which process comprises the steps: (i) compressing one or more monomer(s) under pressure in a compressor, using a compressor lubricant for lubrication, (ii) polymerising a monomer optionally together with one or more comonomer(s) in a polymerisation zone, (iii) separating the obtained polyolefin (a) from the unreacted products and recovering the separated polyolefin (a) in a recovery zone, wherein in step (i) the compressor lubricant comprises a non-mineral oil, power cable, for example a direct current (DC) power cable, use of a polymer composition and a process for producing a DC power cable.

Abstract: A compound of the general formula I or II. The compound of formula I or II is suitable for use in a method for treating a disorder relating to the binding of a galectin, such as galectin-3 to a ligand in a mammal, such as a human. Furthermore, a method for treatment of a disorder relating to the binding of a galectin, such as galectin-3 to a ligand in a mammal, such as a human.

Abstract: A prodrug compound of the general formula I or II. The prodrug compound of formula I or II is suitable for use in a method for treating a disorder relating to the binding of a galectin, such as galectin-3 to a ligand in a mammal, such as a human. Also, a method for treatment of a disorder relating to the binding of a galectin, such as galectin-3 to a ligand in a mammal, such as a human.

Abstract: A cross-linked polymer composition includes a cross-linked polyolefin. Peroxide in an amount of less than 35 mmol —O—O—/kg polymer composition may be included in the polymer composition prior to crosslinking the polyolefin. Suitable polyolefins that can be cross-linked in the polymer composition include an unsaturated LDPE homopolymer and an unsaturated LDPE copolymer of ethylene with one or more comonomers. Such unsaturated LDPE polymer can contain vinyl groups, and the total amount of vinyl groups present in the unsaturated LDPE can be higher than 0.05/1000 carbon atoms. The cross-linked polymer composition can be used, for example, in producing a cross-linkable and cross-linked article such as a cross-linkable and cross-linked direct current (DC) or other type of power cable.

Abstract: Provided is a compound of the general formula (I): The compound of formula (I) is suitable for treating pulmonary fibrosis, such as Idiopathic pulmonary fibrosis in a mammal. Also provided is a method for treatment of pulmonary fibrosis, such as Idiopathic pulmonary fibrosis in a human subject having a galectin-3 level indicative of pulmonary fibrosis or exacerbation of symptoms as well as a method for making said compound.

Abstract: A transmission cable includes a conductor or a bundle of conductors extending along a longitudinal axis, which is circumferentially covered by an insulation layer having an extruded insulation material, whereby the transmission cable passes the electrical type test as specified in Cigré TB496, whereby the rated voltage U0 is 450 kV or more. The type test includes subjecting the power cable to a DC voltage of 1.85*U0 during 10 to 15 cycles at negative polarity, followed by a polarity reversal with another 10 to 15 cycles at positive polarity at a DC voltage of 1.85*U0, followed by additional 2 to 5 cycles during at least 4 to 10 days at positive polarity, and wherein U0 is 450 kV, or 525 kV, or more.

Abstract: The invention relates to polymer composition comprising a polyolefin (a) and an inorganic filler (b) wherein the polyolefin (a) is obtainable by a high pressure process which process comprises the steps: (i) compressing one or more monomer(s) under pressure in a compressor, using a compressor lubricant for lubrication, (ii) polymerising a monomer optionally together with one or more comonomer(s) in a polymerisation zone, (iii) separating the obtained polyolefin (a) from the unreacted products and recovering the separated polyolefin (a) in a recovery zone, wherein in step (i) the compressor lubricant comprises a non-mineral oil, power cable, for example a direct current (DC) power cable, use of a polymer composition and a process for producing a DC power cable.