Abstract: The present invention relates to Map4K1 inhibitors of formula (I) (I), wherein A, E, G, Q, R1, R2 and R4 have the same meaning as defined in the description, to pharmaceutical compositions and combinations comprising the compounds according to the invention, and to the prophylactic and therapeutic use of the inventive compounds, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for neoplastic disorders, respectively cancer or conditions with dysregulated immune responses or other disorders associated with aberrant MAP4K1 signaling, as a sole agent or in combination with other active ingredients.

Abstract: Multiple volumes that are to be aligned to form a single volume are processed. The system and method use an equalization step, a edge detection step and a correlation step to determine the overlapping positions between the first volume and the second volume of a volume pair having a maximum correlation value, and the best alignment of the first volume and the second volume of the volume pair is determined by the correlation value. A coarse correlation step using lower resolution volumes can be performed first followed by a fine correlation step using higher resolution images to save processing time. Initial preprocessing steps such as volume shearing can be performed. Equalization involves equalizing voxel size and edge detection can be performed using a Canny edge detector.

Abstract: Method and apparatus for determining the quality of alignment of a pair of volumes of data of medical images is disclosed. The method for validating the alignment includes selecting one or more points in the first volume and one or more points in the second volume, determining the average distance between the one or more points in the first volume and the one or more points in the second volume, determining a distortion category based on the average distance, determining an average noise level in the first and second volumes, and assigning a Q value indicative of the quality of the alignment based on the distortion category.