Abstract: The invention relates generally to anti-CD161 antibodies, pharmaceutical compositions comprising such antibodies, and methods of using such antibodies for treating disorders associated with or mediated by CD161, for example, certain cancers.

Abstract: The present invention relates to methods for treating or preventing chronic kidney disease and cardiovascular disease in patients with chronic kidney disease comprising administering empagliflozin to the patient.

Abstract: The present invention provides, among other things, a masked cytokine comprising an attenuated interleukin 2 (IL-2) polypeptide, a VHH masking moiety, a carrier moiety and anti-PD1 targeting moiety. In some embodiments, the IL-2 polypeptide is engineered to be activatable by a protease at a target site, such as in a tumor microenvironment, by including a proteolytically cleavable linker. The VHH masking moiety blocks, occludes, inhibits (e.g., decreases) or otherwise prevents (e g masks) the activity or binding of the cytokine to its cognate receptor or protein. Upon proteolytic cleavage of the cleavable linker at the target site, the IL-2 polypeptide becomes activated, which renders it capable of binding to its cognate receptor or protein with increased affinity.

Abstract: An optoelectronic device, in particular an at least partially transparent pane for example of a vehicle, comprises a first layer, in particular an intermediate layer arranged between a cover layer and a carrier layer, at least one electronic or optoelectronic component, which is at least partially or completely embedded in the first layer and at least one structured conductor layer. A first portion of the conductor layer is arranged on an upper surface of the first layer and a second portion of the conductor layer is arranged on a top surface of the electronic or optoelectronic component and is in contact with an electric contact of the electronic or optoelectronic component. The electric contact, in particular a contact pad, is arranged on the top surface.

Abstract: The present invention relates to methods for preventing or treating acute or chronic heart failure and for reducing the risk of cardiovascular death, hospitalization for heart failure and other conditions in patients with preserved or reduced ejection fraction by administering empagliflozin to the patient.

Abstract: The invention relates generally to anti-CD161 antibodies, pharmaceutical compositions comprising such antibodies, and methods of using such antibodies for treating disorders associated with or mediated by CD161, for example, certain cancers. In addition, the invention also relates to expression vectors and host cells for making these antibodies.

Abstract: The invention relates to a method for creating manufacturing data for manufacturing an orthopedic product for a body part of a patient, the method comprising the following steps: providing a digital three-dimensional body part model of the relevant body part for which the orthopedic product is destined to an electronic data processing apparatus, the three-dimensional body part model being based on external body part data acquired from the body part of the patient; identifying at least one rigid body part region in the provided body part model by means of the electronic data processing apparatus, with the remaining region situated outside of the rigid body part region being identified as a yielding body part region on the basis of the identified rigid body part region; creating a reduced three-dimensional body part model by means of the electronic data processing apparatus on the basis of the provided three-dimensional body part model, the identified rigid body part regions and a reduction metric applied in

Abstract: A light emitting device includes a radiation source for the emission of electromagnetic radiation and a converter element on which the electromagnetic radiation impinges in a first surface region and which, excited by the impinged electromagnetic radiation, emits visible light into an environment in a second surface region which differs at least partially from the first surface region. The wavelength of the light emitted into the environment differs from the wavelength of the electromagnetic radiation impinged on the converter element. The converter element includes a luminous element including a textile with a converter material. The converter material due to excitation by the electromagnetic radiation with a first wavelength emits visible light with a second wavelength differing from the first wavelength. The radiation source realizes a background illumination for the converter element. The first surface region is formed by a side surface or a back surface of the converter element.

Abstract: The invention relates to a pharmaceutical composition comprising an SGLT2 inhibitor, a DPPIV inhibitor and a third antidiabetic agent which is suitable in the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia. In addition the present invention relates to methods for preventing or treating of metabolic disorders and related conditions.

Abstract: A method of forming a cochlear implant electrode array includes positioning a contact array assembly, which includes at least one carrier and a plurality of contacts on the at least one carrier, in a mold, removing at least a portion of the at least one carrier from the mold without removing the plurality of contacts from the mold, and introducing resilient material into the mold after the at least a portion of the at least one carrier has been removed to form a flexible body.

Abstract: A refrigerant circuit system, in particular a heat pump system, wherein the refrigerant circuit system has a refrigerant circuit, in which a refrigerant circulates and which is divided into a high-pressure area and a low-pressure area, wherein the refrigerant circuit system has a compressor for compressing the refrigerant arranged in the refrigerant circuit is provided. A pressure and temperature value of the refrigerant in the low-pressure area is measured by a pressure and temperature sensor arranged in the low-pressure area and then a pressure value of the refrigerant in the high-pressure area is determined by the measured pressure and temperature value and a provided compressor characteristic map of the compressor. A refrigerant circuit system for a vehicle is provided and is configured to carry out the method and a vehicle, in particular an electrically powered vehicle, which is equipped with such a refrigerant circuit system.

Abstract: The present invention relates to a method for generating and/or obtaining specific binding moieties against intrinsically disordered proteins (IDPs) and/or intrinsically disordered protein domains which tend to be immunologically inert and lack immunogenicity in animals, in particular in mammals. The present invention also relates to such specific binding moieties, in particular to antibodies and/or to antigen binding fragments thereof, specifically binding to structurally disordered and/or intrinsically disordered sequences, in particular to Pro/Ala-rich sequences (PAS). These binding moieties, antibodies, antigen binding fragments are first in class since they bind to/recognize disordered peptides or polypeptide fragments as also comprised in such “intrinsically disordered proteins”, in particular PAS polypeptides. The inventive binding moieties, antibodies, antigen binding fragments are, without being limiting, particularly useful in diagnostic settings as well as research tools.

Abstract: A vehicle pane includes a light emitting arrangement including a plurality of optoelectronic components on a flexible foil. The vehicle pane also includes a structure including a first pane, a second pane arranged thereon, and at least one at least partially transparent connecting layer connecting the first pane and the second pane. The structure includes an at least partially transparent inner region and an edge region surrounding the inner region. The light emitting arrangement is arranged laterally in the edge region of the structure and the edge region with the light emitting arrangement is configured to direct light generated by the optoelectronic components along the at least partially transparent connecting layer into the at least partially transparent inner region.

Abstract: The invention relates generally to anti-CD161 antibodies, pharmaceutical compositions comprising such antibodies, and methods of using such antibodies for treating disorders associated with or mediated by CD161, for example, certain cancers.

Abstract: An optoelectronic lighting device includes an at least partially transparent base body with a first main surface that is, in particular curved surface, and a second main surface. The second main surface does at least partially not extend parallel to the first main surface. A decorative layer is arranged on the curved first main surface, which substantially follows the curvature of the first main surface. An optoelectronic foil is arranged on the second main surface. The optoelectronic foil includes a carrier substrate that is, in particular a flexible carrier substrate; at least one electrical line and a plurality of optoelectronic semiconductor components arranged on the carrier substrate; and an at least partially transparent adhesive layer, which is arranged between the optoelectronic semiconductor components and the base body and which connects the optoelectronic foil to the second main surface. The optoelectronic semiconductor components are embedded in the adhesive layer.

Abstract: The present invention relates to an ink composition comprising a precursor material for a thermoelectric material, a precursor material for an inorganic binder comprising a mixture of Cu, Se and optionally S powder, an organic solvent and an organic binder. The present invention also relates to a Cu—Se—S-based ink composition for printable thermoelectric materials, comprising a mixture of Cu, Se and S powders. Furthermore, the present invention relates to a flexible printed thermoelectric material obtainable by printing the ink of the present invention. The present invention further relates as well as to a flexible printed high power density thermoelectric generator, heat flux sensor and thermoelectric cooler comprising the flexible printed thermoelectric material and its use, particularly for large scale applications. Further, the present invention also relates to a method for producing the flexible printed thermoelectric material.

Abstract: The invention relates to a support structure for PV modules, which allows the erection of large-area PV plants above parking lots or surfaces for agricultural use.

Abstract: A method of forming a cochlear implant electrode array includes positioning a contact array assembly, which includes at least one carrier and a plurality of contacts on the at least one carrier, in a mold, removing at least a portion of the at least one carrier from the mold without removing the plurality of contacts from the mold, and introducing resilient material into the mold after the at least a portion of the at least one carrier has been removed to form a flexible body.

Abstract: An optoelectronic device comprises a plurality of optoelectronic light sources being arranged on a first layer, in particular an intermediate layer being arranged between a cover layer and a carrier layer. The first layer comprises or consists of an at least partially transparent material and each optoelectronic light source of the plurality of optoelectronic light sources comprises an individual light converter for converting light emitted by the associated light source into converted light. The light converter of each optoelectronic light source is arranged on the first layer and/or the associated optoelectronic light source.