Abstract: Techniques for efficiently capturing targets, such as biological materials, within the air are described. A lightweight, portable device is configured to capture the targets without desiccation by flowing a mixture of air carrying the targets with liquid droplets through a nonlinear path in a partially enclosed interior of the device. For example, a method includes generating an impinging jet comprising a mixture of air, a target, and droplets. A baffle splits the impinging jet into a recirculation zone and coalesces a mixture of the target and the droplets onto an upper surface of the baffle. At least one channel receives the coalesced mixture and transports the coalesced mixture to a collection reservoir.

Abstract: Described herein is an oral sampling device, as well as methods of making and using the oral sampling device. The oral sampling device is configured to be placed inside of a human mouth to capture an analyte(s) found in bodily fluid, such as saliva, produced within the mouth. An example oral sampling device includes a body, at least a portion of which is sized to fit inside of a mouth of a human, has an outer surface, and a recess(es) defined in the outer surface to capture the analyte(s) therein. In some examples, a material of the body within the recess was subjected to a surface treatment to promote the capture of the analyte(s). In some examples, the oral sampling device includes a flavored substance disposed on at least the portion of the body that is to be received inside of a human mouth.

Abstract: Fluidic devices and methods for autonomous droplet generation and methods for droplet manipulation are described. In an embodiment, the fluidic device comprises a substrate defining: an inlet reservoir shaped to receive and to carry a carrier liquid; a converging region in fluidic communication with the inlet reservoir and shaped to receive a liquid sample; a constriction adjacent to and in fluidic communication with the converging region, wherein the constriction defines a pathway configured to allow passage of fluid therethrough; a diverging region in fluidic communication with and downstream of the constriction; and an outlet reservoir in fluidic communication with the diverging region, wherein the fluidic device does not comprise a portion covering the outlet reservoir opposite the substrate.

Abstract: A fluidic device includes a fluidic layer, a capture material, and an electronics layer, the fluidic layer includes a main channel and a pair of sample channels fluidly coupled to the main channel. The pair of sample channels is configured to receive and introduce a sample material into the device. The sample material includes an analyte. The capture material is positioned in a portion of the main channel that is spaced from the pair of sample channels. The capture material has a three-dimensional matrix of receptors therein configured to bond with the analyte. The capture material has a length that is associated with a dynamic range of the fluidic device and a cross-sectional area that is associated with a sensitivity of the fluidic device. The electronics layer includes electrodes configured to measure an electrical resistance through a portion of the capture material.

Abstract: Techniques for efficiently capturing targets, such as biological materials, within the air are described. A lightweight, portable device is configured to capture the targets without desiccation by flowing a mixture of air carrying the targets with liquid droplets through a nonlinear path in a partially enclosed interior of the device. For example, a method includes generating an impinging jet comprising a mixture of air, a target, and droplets. A baffle splits the impinging jet into a recirculation zone and coalesces a mixture of the target and the droplets onto an upper surface of the baffle. At least one channel receives the coalesced mixture and transports the coalesced mixture to a collection reservoir.

Abstract: A fluidic device includes a fluidic layer, a capture material, and an electronics layer, the fluidic layer includes a main channel and a pair of sample channels fluidly coupled to the main channel. The pair of sample channels is configured to receive and introduce a sample material into the device. The sample material includes an analyte. The capture material is positioned in a portion of the main channel that is spaced from the pair of sample channels. The capture material has a three-dimensional matrix of receptors therein configured to bond with the analyte. The capture material has a length that is associated with a dynamic range of the fluidic device and a cross-sectional area that is associated with a sensitivity of the fluidic device. The electronics layer includes electrodes configured to measure an electrical resistance through a portion of the capture material.