Patents by Inventor Ulrich Conrad Dyer

Ulrich Conrad Dyer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents
    Patent number: 6384227
    Abstract: An optically-enrichedpiperidine-2-carboxanlidecompound, in which the piperidine is optionally N-alkylated, is racemized by heating the compound in an aqueous medium, provided that the medium includes an organic co-solvent if the compound is N-alkylated. This process is particularly valuable, in conjunction with a resolution process, for the manufacture of levobupivacaine.
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: May 7, 2002
    Assignee: Darwin Discovery Ltd.
    Inventors: Ulrich Conrad Dyer, Marianne Langston, Martin Woods
  • Racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents
    Publication number: 20010000522
    Abstract: An optically-enriched piperidine-2-carboxanlidecompound, in which the piperidine is optionally N-alkylated, is racemised by heating the compound in an aqueous medium, provided that the medium includes an organic co-solvent if the compound is N-alkylated. This process is particularly valuable, in conjunction with a resolution process, for the manufacture of levobupivacaine.
    Type: Application
    Filed: December 18, 2000
    Publication date: April 26, 2001
    Inventors: Ulrich Conrad Dyer, Marianne Langston, Martin Woods
  • Racemization of precursors to levobupivacaine and analogues thereof
    Patent number: 6156900
    Abstract: A process for the preparation of optically-enriched pipecolic acid as a salt with an optically-active acid, comprises asymmetric transformation of pipecolic acid, as a racemic mixture of a mixture enriched in the opposite enantiomer from that desired, with the optically-active acid in a solvent comprising an acid that causes racemisation, in the absence of aldehyde.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: December 5, 2000
    Assignee: Darwin Discovery Limited
    Inventors: Ulrich Conrad Dyer, Martin Woods, Raymond McCague
  • Process for preparing galanthamine derivatives by asymmetric reduction
    Patent number: 6018043
    Abstract: The subject invention concerns a process for preparing a compound of formula (3) ##STR1## in enantio-enriched form, comprising reducing a compound of formula (4) ##STR2## using an asymmetric enantiospecific reductant, wherein A.sup.1 .dbd.A.sup.2 .dbd.H or A.sup.1, A.sup.2 .dbd.O; B.sup.1 .dbd.B.sup.2 .dbd.H or B.sup.1, B.sup.2 .dbd.O; Z.dbd.H, C.sub.1-20 alkyl or a precursor thereof, or a removable protecting group for nitrogen, e.g, acyl or alkyloxycarbonyl; Y.dbd.H or a substituent; R.sup.1 .dbd.C.sub.1-20 alkyl; and R is an optional, additional substituent.
    Type: Grant
    Filed: February 2, 1998
    Date of Patent: January 25, 2000
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Ulrich Conrad Dyer, Jane Marie Paul, Raymond McCague
  • Process for the resolution of etodolac using glucamine derivatives
    Patent number: 5811558
    Abstract: The subject invention pertains to a process for the resolution of etodolac comprising the use of the resolving agent glucamine or a N-(C.sub.1-4 alkyl)-glucamine. The subject invention also concerns a process for converting a single enantiomer of etodolac into the racemate. The method comprises forming all ester of the carboxylate function of the enantiomer and treating with an acid or base.
    Type: Grant
    Filed: December 6, 1996
    Date of Patent: September 22, 1998
    Assignee: Chiroscience Limited
    Inventors: Brian Michael Adger, Ulrich Conrad Dyer, Martin Woods, John Francis Paul Andrews, Helen Frances Baker
  • Racemization and asymmetric transformation processes used in the manufacture of levobupivacaine and analogues thereof
    Patent number: 5786484
    Abstract: A process for the racemisation of an optically-enriched piperidine-2-carboxanilide compound, comprises heating the compound in the presence of an alkanoic or arylalkanoic acid. A process for the asymmetric transformation of such a compound comprises heating the compound in the presence of an acid as defined above, a chiral acid resolving agent and an inert cosolvent.
    Type: Grant
    Filed: May 30, 1997
    Date of Patent: July 28, 1998
    Assignee: Chiroscience Limited
    Inventors: Ulrich Conrad Dyer, Christopher James Lock, Martin Woods