Abstract: The present invention can be included in the field of medicine. Specifically, the present invention provides antibodies and antigen-binding fragments thereof which can bind isoAsp7 amyloid ? (A?) and a pharmaceutical composition comprising the antibodies or antigen-binding fragments thereof. IsoAsp7 A? can be found in plaques of Alzheimer's patients and is thus a suitable target for the treatment and/or prevention of A?-related diseases such as Alzheimer's disease. Thus, the antibodies, antigen-binding fragments thereof and the pharmaceutical composition comprising either can be used to treat and/or prevent neurodegenerative diseases. Further, the present invention provides hybridoma cell lines, the use of the antibodies or antigen-binding fragments thereof for the diagnosis and/or prognosis of a neurodegenerative disease and a method for detecting isoAsp7 A? in an isolated sample.

Abstract: The present invention relates to bacterial glutaminyl cyclases and inhibitors thereof for use in the treatment of periodontitis and related conditions, and provides a bacterial glutaminyl cyclase (bacQC); an antibody which recognizes the bacQC, a method for identifying an inhibitor of the bacQC; a compound according to Formula (I); a pharmaceutical composition comprising a bacQC inhibitor compound; a bacQC inhibitor compound and/or a pharmaceutical composition for use in a method for treatment of the human or animal body, for use in a method for therapy or prophylaxis of a bacterial infection, and for use in a method for therapy and/or prophylaxis of an acute, chronic or recurrent periodontal disease.

Abstract: A system for detecting, analyzing and manipulating devices, wherein a virtual graphics component displays an operating state of the device and is integrated in a moving image of the device as a complete image, and wherein the complete image is updated at regular time intervals.

Abstract: A measuring apparatus having a housing, at least one internal sensor, an electronic control unit, at least one radio module, an operating device and an information carrier. The measuring apparatus is configured to be connected to external sensors by cable and/or wirelessly, the electronic control unit is configured to convert measurement signals from internal and external sensors into digital measurement data and to provide the digital measurement data to the information carrier. The information carrier is configured to provide and display as priority, in the case of simultaneous availability of wired or wireless sensors, either the data of the wired sensors or the data of the wireless sensors. A system for performing measurement tasks and managing measurement data, and methods for starting up and/or maintaining an air conditioning system are also provided, as well as methods for starting up and/or maintaining a system.

Abstract: The present invention relates to novel hydroxamic acid derivatives as inhibitors of meprin ? and/or ?, pharmaceutical compositions comprising such compounds, methods for treatment or prophylaxis of diseases or conditions, especially such that are related to meprin ? and/or ?, and compounds and pharmaceutical compositions for use in such methods.

Abstract: A housing for a measuring device for accommodating a transmission unit for transmitting data, and/or display unit for the readout of data, and a terminal unit provided for supplying electric power to the measuring device, having at least two housing compartments, wherein the transmission unit and/or the display unit and the terminal unit can each be arranged in different housing compartments, and axes of the housing compartments formed in each case by a surface normal of an outward facing housing opening of a housing compartment, or axes formed in each case by a surface normal of the cap closing the housing openings, cross one another. A measuring device is also provided that includes the housing, and a transmission and analysis system that includes such a measuring device.

Abstract: The present invention relates to novel hydroxamic acid derivatives as inhibitors of meprin ? and/or ?, pharmaceutical compositions comprising such compounds, methods for treatment or prophylaxis of diseases or conditions, especially such that are related to meprin ? and/or ?, and compounds and pharmaceutical compositions for use in such methods.

Abstract: A sensor structure and a method for producing the sensor structure. A base material is applied to a transfer support. The transfer support is arranged on a sensor body, and at least parts of the base material are transferred from the transfer support to the sensor body via local energy input.

Abstract: The present invention can be included in the field of medicine. Specifically, the present invention provides antibodies and antigen-binding fragments thereof which can bind isoAsp7 amyloid ? (A?) and a pharmaceutical composition comprising the antibodies or antigen-binding fragments thereof. IsoAsp7 A? can be found in plaques of Alzheimer's patients and is thus a suitable target for the treatment and/or prevention of A?-related diseases such as Alzheimer's disease. Thus, the antibodies, antigen-binding fragments thereof and the pharmaceutical composition comprising either can be used to treat and/or prevent neurodegenerative diseases. Further, the present invention provides hybridoma cell lines, the use of the antibodies or antigen-binding fragments thereof for the diagnosis and/or prognosis of a neurodegenerative disease and a method for detecting isoAsp7 A? in an isolated sample.

Abstract: The present invention relates to bacterial glutaminyl cyclases and inhibitors thereof for use in the treatment of periodontitis and related conditions, and provides a bacterial glutaminyl cyclase (bacQC); an antibody which recognizes the bacQC, a method for identifying an inhibitor of the bacQC; a compound according to Formula (I); a pharmaceutical composition comprising a bacQC inhibitor compound; a bacQC inhibitor compound and/or a pharmaceutical composition for use in a method for treatment of the human or animal body, for use in a method for therapy or prophylaxis of a bacterial infection, and for use in a method for therapy and/or prophylaxis of an acute, chronic or recurrent periodontal disease.

Abstract: The present invention relates to novel hydroxamic acid derivatives as inhibitors of meprin ? and/or ?, pharmaceutical compositions comprising such compounds, methods for treatment or prophylaxis of diseases or conditions, especially such that are related to meprin ? and/or ?, and compounds and pharmaceutical compositions for use in such methods.

Abstract: A sensor structure and a method for producing the sensor structure. A base material is applied to a transfer support. The transfer support is arranged on a sensor body, and at least parts of the base material are transferred from the transfer support to the sensor body via local energy input.

Abstract: A housing for a measuring device for accommodating a transmission unit for transmitting data, and/or display unit for the readout of data, and a terminal unit provided for supplying electric power to the measuring device, having at least two housing compartments, wherein the transmission unit and/or the display unit and the terminal unit can each be arranged in different housing compartments, and axes of the housing compartments formed in each case by a surface normal of an outward facing housing opening of a housing compartment, or axes formed in each case by a surface normal of the cap closing the housing openings, cross one another. A measuring device is also provided that includes the housing, and a transmission and analysis system that includes such a measuring device.

Abstract: The invention relates to the use of a compound of formula (I), or a composition containing the compound, as glutaminyl cyclase (QC) inhibitor and to methods of preparation.

Abstract: A hydraulic tool including a tank, which is filled with oil, a hand pump connected to the tank in fluid communication, having a spring-loaded lever mechanism, which is in operative connection with a pump piston, with a piston cylinder system as actuator, which is connected to the pump in fluid communication with a non-return valve, wherein the piston surface of the actuator is a multiple of the piston surface of the hand pump.