Patents by Inventor Ulrich Eder
Ulrich Eder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240067750Abstract: The present invention relates to monoclonal antibodies and antigen binding fragments thereof that bind to human Factor XI and activated Factor XI (“Factor XIa”), and pharmaceutical compositions and methods of treatment comprising the same.Type: ApplicationFiled: January 20, 2023Publication date: February 29, 2024Inventors: Jorg EDER, Stefan EWERT, Ulrich HASSIEPEN, Yasser KHDER, Lorenz MAYR, Samu MELKKO, Nikolaus SCHIERING
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Patent number: 5010077Abstract: A .beta.-carbolin-3-carboxylic acid derivative of the formula ##STR1## wherein: X is oxygen, sulphur or NR.sup.10, wherein R.sup.10 is hydrogen, C.sub.1-6 -alkyl, C.sub.1-6 -alkenyl, C.sub.3-7 -cycloalkyl or C.sub.3-7 -cycloalkenyl;R.sup.3 is (a) C.sub.1-10 -alkoxy, C.sub.1-10 -alkenyloxy, C.sub.6-10 -aryloxy, C.sub.7-11 -aralkoxy or C.sub.8-12 -aralkenyloxy, each optionally substituted with one or more hydroxy groups, halogen atoms, CF.sub.3 groups, C.sub.1-10 -alkoxy groups or C.sub.2-4 -alkenyloxy groups or each optionally substituted with an amino, di-C.sub.1-6 -alkylamino, C.sub.1-10 -alkoxycarbonyl or C.sub.1-10 -alkenyloxycarbonyl group; or (b) NR.sup.11 R.sup.12, wherein R.sup.11 and R.sup.12 are the same or different and each is (i) hydrogen, (ii) hydroxy, (iii) C.sub.1-10 -alkyl, (iv) C.sub.2-10 -alkenyl, (v) C.sub.6-10 -aryl, (vi) C.sub.7-11 -aralkyl, (vii) C.sub.8-12 -aralkenyl, (viii) C.sub.3-7 -cycloalkyl, or (ix) C.sub.Type: GrantFiled: April 25, 1988Date of Patent: April 23, 1991Assignees: A/S Ferrosan, Schering AktiengesellschaftInventors: Claus T. Braestrup, Mogens C. Nielsen, Joergen A. Christensen, Mogens Engelstoft, Henning Schou, Ulrich Eder, Gunter Neef, Andreas Huth, Dieter Rahtz, Ralph Schmiechen
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Patent number: 4826852Abstract: Ergolinyl compounds which are nitrogen-substituted in the 8-position and have Formula (I) ##STR1## and physiologically compatible salts thereof, wherein (a) R.sup.1 is hydrogen, the 8-substituent can be in the .alpha.- or .beta.-position and ##STR2## represents a single or a double bond, R.sup.2 is hydrogen, C.sub.1-4 -alkyl or C.sub.1-7 -acyl,R.sup.3 is hydrogen, chlorine or bromine, andR.sup.4 is C.sub.1-6 -alkyl, C.sub.3-6 -cycloalkyl-C.sub.1-3 -alkyl, C.sub.3-6 -alkenyl, or C.sub.3-6 -alkynyl; or(b) R.sup.1 is ##STR3## and the 8-substituent can be in the .alpha.- or .beta.-position, ##STR4## represents a single or double bond, R.sup.2, R.sup.3 are as defined above,R.sup.4, is C.sub.1.varies.6 -alkyl, C.sub.3-6 -cycloalkyl-C.sub.1-3 -alkyl, C.sub.3-6 -alkenyl, or C.sub.3-6 -alkynyl; andR.sup.5 is hydrogen, C.sub.-10 -alkyl, C.sub.3-10 -alkenyl, or C.sub.3-10 -alkynyl, andR.sup.6 is C.sub.1-10 -alkyl, C.sub.3-10 -alkenyl, C.sub.3-10 -alkynyl, or aryl, orR.sup.5 and R.sup.Type: GrantFiled: June 26, 1986Date of Patent: May 2, 1989Assignee: Schering AktiengesellschaftInventors: Gregor Haffer, Gerhard Sauer, Helmut Wachtel, Herbert Schneider, Ulrich Eder
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Patent number: 4601746Abstract: New substituted sulfonyl urea are disclosed of the general formula ##STR1## in which R.sub.1 is chlorine, --COOR.sub.5, --S(O).sub.n --R.sub.6 or ##STR2## R.sub.2 is ##STR3## or --CH.sub.2 --C.tbd.C--R.sub.11, R.sub.3 is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkylthio, halogen, halogen-C.sub.1 -C.sub.4 -alkyl, halogen-C.sub.1 -C.sub.4 -alkoxy, Di-C.sub.1 -C.sub.3 -alkyl-amino, C.sub.1 -C.sub.3 -alkyl-amino or C.sub.1 -C.sub.3 -alkoxy-C.sub.1 -C.sub.3 -alkoxy,R.sub.4 is hydrogen C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -alkylthio, halogen, halogen-C.sub.1 -C.sub.4 -alkyl, halogen-C.sub.1 -C.sub.4 -alkoxy, Di-C.sub.1 -C.sub.3 -alkyl-amino, C.sub.1 -C.sub.3 -alkyl-amino, or C.sub.1 -C.sub.3 -alkoxy-C.sub.1 -C.sub.3 -alkoxy,Z is --CH.dbd. or --N.dbd.,R.sub.5 is C.sub.1 -C.sub.8 -alkyl, C.sub.3 -C.sub.8 -cycloalkyl, C.sub.1 -C.sub.3 -alkoxy-C.sub.1 -C.sub.3 -alkyl, phenyl, substituted phenyl, benzene or substituted benzene,R.sub.6 is C.sub.1 -C.sub.6 -alkyl or phenyl,R.Type: GrantFiled: June 18, 1984Date of Patent: July 22, 1986Assignee: Schering AktiengesellschaftInventors: Jurgen Westermann, Gerhard Boroschewski, Ulrich Eder, Friedrich Arndt, Hansjorg Krahmer, Clemens Kotter
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Patent number: 4596808Abstract: 3-Substituted beta-carbolines of the formula ##STR1## wherein R.sup.A is H, F, Cl, Br, I, NO.sub.2, CN, CH.sub.3, CF.sub.3, SCH.sub.3, NR.sup.16 R.sup.17 or NHCOR.sup.16,wherein R.sup.16 and R.sup.17 are the same or different and each is hydrogen or alkyl, alkenyl or alkynyl each of up to 6 C-atoms, aralkyl or cycloalkyl each of up to 10 C-atoms,or wherein R.sup.16 and R.sup.17 together form a saturated or unsaturated 3-7 membered heterocyclic ring;said compounds possess valuable psychotropic properties which make them useful for example as tranquilizers.Type: GrantFiled: December 1, 1983Date of Patent: June 24, 1986Assignee: Schering AktiengesellschaftInventors: Claus T. Braestrup, Jogen A. Christensen, Mogens Engelstoft, Guenter Neef, Ulrich Eder, Ralph Schmiechen, Andreas Huth, Dieter Rahtz, Dieter Seidelmann, Wolfgang Kehr, Dieter Palenschat
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Patent number: 4591650Abstract: New hexanor-brassinolid-22-ethers are disclosed, of the formula ##STR1## wherein Z is the group ##STR2## OR.sub.2 and OR.sub.3 are oriented cis 2.alpha., 3.alpha. or 2.beta., 3.beta., R.sub.2 and R.sub.3 are the same or different and are each hydrogen formyl, C.sub.2 -C.sub.7 -alkyl-CO--, C.sub.2 -C.sub.7 -alkoxy-C.sub.1 -C.sub.3 -alkyl-CO-- or aryl-CO--, and R.sub.23 is straight-chain or branched C.sub.1 -C.sub.7 -alkyl or C.sub.1 -C.sub.7 -alkoxy-C.sub.1 -C.sub.3 -alkyl. Also disclosed are processes for the production of these compounds as well as compositions containing the same having growth-regulatory activity for plants.Type: GrantFiled: February 13, 1984Date of Patent: May 27, 1986Assignee: Schering AktiengesellschaftInventors: Ulrich Kerb, Ulrich Eder, Hansjorg Krahmer
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Patent number: 4435403Abstract: 3-substituted beta-carbolines of the formula ##STR1## wherein R.sup.C is hydrogen, lower alkyl, alkoxyalkyl of up to 6 C-atoms, cycloalkyl of 3-6 C-atoms, aralkyl of up to 8 C-atoms, or (CH.sub.2).sub.n OR.sup.20wherein R.sup.20 is alkyl of up to 6 C-atoms, cycloalkyl of 3-6 C-atoms or aralkyl of up to 8 C-atoms and n is an integer of 1 to 3;Y is oxygen, two hydrogen atoms or NOR.sup.1,wherein R.sup.1 is hydrogen, lower alkyl, aryl or aralkyl of up to 6 C-atoms, COR.sup.2, wherein R.sup.2 is lower alkyl of up to 6 C-atoms,or Y is CHCOOR.sup.3, wherein R.sup.3 is hydrogen or lower alkylor Y is NNR.sup.4 R.sup.5,wherein R.sup.4 and R.sup.5 can be the same or different and each is hydrogen, lower alkyl, C.sub.6-10 -aryl, C.sub.7-10 -aralkyl or CONR.sup.6 R.sup.7,wherein R.sup.6 and R.sup.7 can be the same or different and each is hydrogen or lower alkyl or R.sup.4 and R.sup.Type: GrantFiled: December 17, 1981Date of Patent: March 6, 1984Assignee: Schering AktiengesellschaftInventors: Claus T. Braestrup, Jogen A. Christensen, Mogens Engelstoft, Gunter Neef, Ulrich Eder, Ralph Schmiechen, Andreas Huth, Dieter Rahtz, Dieter Seidelmann, Wolfgang Kehr, Dieter Palenschat
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Patent number: 4379790Abstract: Compounds of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein R.sub.1 is alkyl of 2-6 carbon atoms, ##STR2## n is 1, or 2, m is 0 or 1,R.sub.2 is alkyl of 1-6 carbon atoms, ##STR3## is a CC single bond or a CC double bond, and the 8-positioned urea residue can be in the .alpha.- or .beta.-position, have valuable pharmacological properties, e.g., lactation inhibition and anti-Parkinsonism.Type: GrantFiled: January 6, 1982Date of Patent: April 12, 1983Assignee: Schering AktiengesellschaftInventors: Reinhard Horowski, Wolfgang Kehr, Gerhard Sauer, Ulrich Eder, Hans P. Lorenz
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Patent number: 4371536Abstract: A .beta.-carbolin-3-carboxylic acid derivative of the formula ##STR1## has valuable pharmacological properties when administered to patients, e.g. humans as a drug, have been shown to possess interesting tranquilizing activity.Type: GrantFiled: August 28, 1980Date of Patent: February 1, 1983Assignees: A/S Ferrosan, Scherling AGInventors: Claus T. Braestrup, Mogens C. Nielsen, Joergen A. Christensen, Mogens Engelstoft, Henning Schou, Ulrich Eder, Gunter Neef, Andreas Huth, Dieter Rahtz, Ralph Schmiechen
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Patent number: 4333928Abstract: 16 .alpha.-Alkyl steroids of the formula ##STR1## wherein R.sub.1 is hydrogen or methyl,R.sub.2 is hydrogen, alkyl, acyl, or glycosylR.sub.3 is hydrogen or a substituted or unsubstituted, saturated or unsaturated lower hydrocarbon residue, andR.sub.4 is methyl, ethyl or propyl, exhibit strong progestational activity and a very low androgenic activity.Type: GrantFiled: May 16, 1980Date of Patent: June 8, 1982Assignee: Schering, AktiengesellschaftInventors: Gunter Neef, Ulrich Eder, Gregor Haffer, Gerhard Sauer, Rudolf Wiechert, Hermann Steinbeck
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Patent number: 4298538Abstract: 16-dimethylaminomethylene-3-methoxy-1,3,5(10)-estratrien-17-one is a valuable new preparative intermediate which may be used, e.g., to prepare 17.beta.-hydroxy-16.beta.-ethyl-4-estren-3-one or 16.beta.-ethylestradiol.Type: GrantFiled: December 18, 1979Date of Patent: November 3, 1981Assignee: Schering, AktiengesellschaftInventors: Gunter Neef, Ulrich Eder, Gregor Haffer, Gerhard Sauer
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Patent number: 4202991Abstract: Bicycloalkane derivatives of the formula ##STR1## wherein n is 1 or 2, R.sub.1 is lower alkyl, Acyl is alkanoyl, and Y is --S--R.sub.2, --SO.sub.m --R.sub.2, or ##STR2## wherein m is 1 or 2, R.sub.2 is alkyl, R.sub.3 is hydrogen or lower alkyl, R.sub.4 is acyl or phenyl optionally substituted with lower alkoxy, benzyloxy or alkanoyloxy; and Z is nitro, lower alkoxycarbonyl, lower alkanoyl, lower alkylsulfinyl, or lower alkylsulfonyl are useful intermediates in the total synthesis of steroids. The compounds are prepared by reacting a corresponding compound lacking the CH.sub.2 Y substituent with formaldehyde and a mercaptan or sulfinic acid, followed if desired by oxidation and optional salt condensation.Type: GrantFiled: December 27, 1976Date of Patent: May 13, 1980Assignee: Schering AktiengesellschaftInventors: Gerhard Sauer, Helmut Hauser, Gregor Haffer, Juergen Ruppert, Ulrich Eder, Rudolf Wiechert
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Patent number: 4178381Abstract: C-homoestratrienes of the formula ##STR1## wherein ##STR2## R.sub.1 and R.sub.2 are the same or different, and each is hydrogen, acyl, alkyl, cycloalkyl or tetrahydropyranyl; andR.sub.3 is hydrogen, ethynyl or chloroethynyl; possess very good estrogenic properties.Type: GrantFiled: December 4, 1978Date of Patent: December 11, 1979Assignee: Schering, AktiengesellschaftInventors: Gregor Haffer, Ulrich Eder, Gerhard Sauer, Rudolf Wiechert, Yukishige Nishino, Gunter Neef
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Patent number: 4170518Abstract: Sterol derivatives of the formula ##STR1## wherein R.sub.1 is a hydrogen atom and R.sub.2 is lower alkoxy, or R.sub.1 and R.sub.2 collectively are lower alkylenedioxy and R.sub.3 is a sterol hydrocarbon side chain are converted to the corresponding androsten-17-ones by the oxidative degradation activity of a species of microorganism which degrades sterol side chains, preferably of the genus Mycobacterium. The ether group of those compounds wherein R.sub.1 is a hydrogen atom and R.sub.2 is lower alkoxy, and the corresponding 17.beta.-hydroxy and 17.alpha.-hydrocarbon-17.beta.-hydroxy compounds is cleaved by reaction with an alkanoic acid chloride or anhydride in the presence of a Lewis acid.Type: GrantFiled: July 30, 1976Date of Patent: October 9, 1979Assignee: Schering AktiengesellschaftInventors: Alfred Weber, Mario Kennecke, Alfred Popper, Rudolf Muller, Ulrich Eder, Gregor Haffer, Gerhard Sauer, Gunter Neef, Rudolf Wiechert
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Patent number: 4155923Abstract: A process for the preparation of 17.beta.-hydroxy-20-alkoxypregnane-21-oic acid derivatives of the formula ##STR1## WHEREIN R.sub.1 is methyl or ethyl;R.sub.2 is hydrogen or methyl, either being in the .alpha.-or .beta.-position;R.sub.3 is lower alkyl of 1-4 carbon atoms;R.sub.4 is alkyl of 1-8 carbon atoms or benzyl; andSt is the residue of a steroid ABC ring system;Comprises reacting (a) a 17-oxo compound of the formula ##STR2## WHEREIN R.sub.1 and R.sub.2 are as defined above andSt* is said steroid ABC ring system residue, St, in a form which is chemically compatible with said reaction;With (b) an enolate ion of an alkoxyacetic acid alkyl ester of the formula ##STR3## wherein R.sub.3 and R.sub.4 are as defined above.Type: GrantFiled: January 30, 1978Date of Patent: May 22, 1979Assignee: Schering AktiengesellschaftInventors: Gunter Neef, Gregor Haffer, Ulrich Eder, Gerhard Sauer, Rudolf Wiechert
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Patent number: 4108871Abstract: Novel benzopyran derivatives of the formula ##STR1## wherein R.sub.1 and R.sub.3 each are lower alkyl; n is the integer 1 or 2; --A--B-- is >CH--CH.sub.2 -- or >CH.dbd.CH--; X is a free, esterified or etherified hydroxy group; and Y is H or X and Y collectively are .dbd.O; and W is --(CH.sub.2).sub.3 --Z--R.sub.4, ##STR2## --(CH.sub.2).sub.3 --COOR.sub.6 or --(CH.sub.2).sub.3 CN, wherein V is halogen, Z is a ketalized carbonyl group or a free, esterified or etherified hydroxymethylene group, R.sub.4 and R.sub.5 each are lower alkyl and R.sub.6 is alkyl, aryl or aralkyl, are valuable intermediates in the synthesis of steroids.Type: GrantFiled: March 5, 1976Date of Patent: August 22, 1978Assignee: Schering AktiengesellschaftInventors: Ulrich Eder, Gerhard Sauer, Gregor Haffer, Jurgen Ruppert, Rudolf Wiechert
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Patent number: 4100027Abstract: A process for the preparation of 4-androstene-3,17-dione derivatives of the formula ##STR1## wherein X is 6,7-methylene or fluoro, chloro, or methyl in the 6- or 7-position, comprises fermenting a sterol of the formula ##STR2## wherein X is as above and R.sub.1 is a hydrocarbon residue of 8-10 carbon atoms with a microorganism culture capable of degrading the side chain of a sterol.Type: GrantFiled: December 16, 1976Date of Patent: July 11, 1978Assignee: Schering AktiengesellschaftInventors: Alfred Weber, Mario Kennecke, Rudolf Mueller, Ulrich Eder, Rudolf Wiechert
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Patent number: 4100026Abstract: A process for the preparation of 4-androstene-3,17-dione derivatives of the formula ##STR1## wherein X is 1,2-methylene or 1- or 2-methyl, comprises fermenting a sterol derivative of the formula ##STR2## wherein X is as above, the bond is a single or double bond, and R.sub.1 is the hydrocarbon residue, of 8-10 carbon atoms, of a sterol, with a microorganism culture capable of the side chain degradation of sterols.Type: GrantFiled: December 17, 1976Date of Patent: July 11, 1978Assignee: Schering AktiengesellschaftInventors: Alfred Weber, Mario Kennecke, Rudolf Mueller, Ulrich Eder, Rudolf Wiechert
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Patent number: 4097334Abstract: A process for the preparation of androstane-3,17-dione compounds of the formula ##STR1## wherein X is 1,2-methylene or 1- or 2-methyl, comprises fermenting a sterol of the formula ##STR2## wherein X is as above and R.sub.1 is the hydrocarbon residue of 8-10 carbon atoms, of a sterol, with a microorganism culture capable of effecting the side chain degradation of sterols.Type: GrantFiled: December 17, 1976Date of Patent: June 27, 1978Assignee: Schering AktiengesellschaftInventors: Alfred Weber, Mario Kennecke, Rudolf Mueller, Ulrich Eder, Rudolf Wiechert
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Patent number: 4077996Abstract: A process for the preparation of trans-decahydronaphthalene compounds of Formula I ##STR1## wherein X is lower alkyl, --(CH.sub.2).sub.3 --Z--R.sub.2, ##STR2## --(CH.sub.2).sub.3 COOR.sub.4, or --(CH.sub.2).sub.3 CN; Y and Z are ketalized carbonyl or free, esterified, or etherified hydroxymethylene;U is halogen;R.sub.1, r.sub.2, and R.sub.3 are lower alkyl; andR.sub.4 is alkyl;Wherein an octahydronaphthalene compound of Formula II ##STR3## is converted, in the presence of bases, by reaction of a trialkyl chlorosilane of the formula(R.sub.5).sub.3 Si--Clwherein the R.sub.5 each are lower alkyl group, to a hexahydronaphthalene compound of the formula ##STR4## The hexahydronaphthalene compound is hydrogenated, in an inert solvent with hydrogen in the presence of a platinum-, palladium-, or rhodium-containing hydrogenation catalyst, to an octahydronaphthalene compound of the formula ##STR5## and a vinyl ketone of the formulaXCOCH.dbd.CH.sub.Type: GrantFiled: April 14, 1976Date of Patent: March 7, 1978Assignee: Schering AktiengesellschaftInventors: Gerhard Sauer, Ulrich Eder, Gregor Haffer, Gunter Neef, Rudolf Wiechert