Patents by Inventor Ulrich Grummert
Ulrich Grummert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11931733Abstract: A device and a method for repeatedly modifying the composition of a fluid. The device includes a first module (19) modifying the composition of the fluid, a second module (21) modifying the composition of the fluid and a dwell module (20) with an inlet (8) and an outlet (10). The first module is connected in a fluid-conducting manner to the dwell module inlet and the dwell module outlet is connected in a fluid-conducting manner to the second module. Either the first or the second module is a filter unit, or the first module is a first filter unit and the second module is a second filter unit. The filter unit(s) include(s) at least one first filter medium (4, 14) delimiting a supply channel (2, 12) and a retentate channel (1, 11) and at least one second filter medium (5, 15) delimiting the retentate channel and a permeate channel (3, 13).Type: GrantFiled: June 4, 2021Date of Patent: March 19, 2024Assignee: Sartorius Stedim Biotech GmbHInventors: Martin Leuthold, Alexander Helling, Ulrich Grummert
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Patent number: 11612861Abstract: A crossflow filtration unit for continuous diafiltration of a feed fluid for obtaining a retentate and a permeate, a corresponding method for diafiltration and the use of the crossflow filtration unit are provided. The crossflow filtration unit includes a diafiltration channel, a flat first filter material, a retentate channel, a flat second filter material, and a permeate collection channel, arranged such that the flat first filter material delimits the diafiltration channel and the retentate channel from one another, and the flat second filter material delimits the retentate channel and the permeate collection channel from one another. The diafiltration channel is fluidly connected to at least one inlet for the diafiltration medium, the retentate channel is fluidly connected to at least one inlet for the feed fluid and to at least one outlet for the retentate. The permeate collection channel is fluidly connected to at least one outlet for the permeate.Type: GrantFiled: October 3, 2018Date of Patent: March 28, 2023Assignee: SARTORIUS STEDIM BIOTECH GMBHInventors: Martin Leuthold, Ulrich Grummert, Peter Schmidt
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Patent number: 11219867Abstract: The proposed prefabricated filtration module is provided for a modular filtration system, in particular a cross-flow filtration system, for low-volume screening applications. The prefabricated filtration module includes fluid ports and a plurality of components adjusted to low-volume screening applications, which are firmly integrated into the filtration module. The entire filtration module is designed as a single-use filtration module.Type: GrantFiled: May 8, 2018Date of Patent: January 11, 2022Assignee: SARTORIUS STEDIM BIOTECH GMBHInventors: Ulrich Grummert, Martin Leuthold
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Publication number: 20210291161Abstract: A device and a method for repeatedly modifying the composition of a fluid. The device includes a first module (19) modifying the composition of the fluid, a second module (21) modifying the composition of the fluid and a dwell module (20) with an inlet (8) and an outlet (10). The first module is connected in a fluid-conducting manner to the dwell module inlet and the dwell module outlet is connected in a fluid-conducting manner to the second module. Either the first or the second module is a filter unit, or the first module is a first filter unit and the second module is a second filter unit. The filter unit(s) include(s) at least one first filter medium (4, 14) delimiting a supply channel (2, 12) and a retentate channel (1, 11) and at least one second filter medium (5, 15) delimiting the retentate channel and a permeate channel (3, 13).Type: ApplicationFiled: June 4, 2021Publication date: September 23, 2021Inventors: Martin LEUTHOLD, Alexander HELLING, Ulrich GRUMMERT
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Publication number: 20210155888Abstract: A bioreactor having a filter unit and a method for treating a cell broth. The filter unit has a supply channel (2), a first filter medium (4), a retentate channel (1), a second filter medium (5) and a permeate channel (3), arranged so that the first filter medium delimits the supply channel and the retentate channel from one another; and the second filter medium delimits the retentate channel and the permeate channel from one another. The supply channel is connected to an inlet for a supply medium; the retentate channel is connected to an inlet for a cell broth and to an outlet for the cell broth; the permeate channel is connected to an outlet for a permeate; and the interior of the bioreactor is connected to the inlet for the cell broth and to the outlet for the cell broth.Type: ApplicationFiled: February 5, 2021Publication date: May 27, 2021Inventors: Martin LEUTHOLD, Alexander HELLING, Ulrich GRUMMERT
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Publication number: 20200276539Abstract: A filter device (10), in particular for a tangential flow filtration device, has at least one fluid inlet (22), at least one retentate outlet (24) and at least one permeate outlet (26). The filter device (10) further has at least one membrane (16) which separates a retentate section (18) from a permeate section (20) in the filter device (10). Arranged in the retentate section (18) and/or in the permeate section (20) is at least one flow fitting (28) which is not formed from a woven or non-woven fabric, but from a structured plastic part, silicone part, metal part or ceramic part.Type: ApplicationFiled: September 17, 2018Publication date: September 3, 2020Inventors: Stefan WEISSHAAR, Martin LEUTHOLD, Ulrich GRUMMERT, Matthias WESSLING, Kristina BAITALOW, Jonas LOELSBERG
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Publication number: 20200078740Abstract: The proposed prefabricated filtration module (10) is provided for a modular filtration system, in particular a cross-flow filtration system, for low-volume screening applications. The prefabricated filtration module (10) includes fluid ports (24) and a plurality of components adjusted to low-volume screening applications, which are firmly integrated into the filtration module (10). The entire filtration module (10) is designed as a single-use filtration module.Type: ApplicationFiled: May 8, 2018Publication date: March 12, 2020Inventors: Ulrich GRUMMERT, Martin LEUTHOLD
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Publication number: 20190030486Abstract: A crossflow filtration unit for continuous diafiltration of a feed fluid for obtaining a retentate and a permeate, a corresponding method for diafiltration and the use of the crossflow filtration unit are provided. The crossflow filtration unit includes a diafiltration channel, a flat first filter material, a retentate channel, a flat second filter material, and a permeate collection channel, arranged such that the flat first filter material delimits the diafiltration channel and the retentate channel from one another, and the flat second filter material delimits the retentate channel and the permeate collection channel from one another. The diafiltration channel is fluidly connected to at least one inlet for the diafiltration medium, the retentate channel is fluidly connected to at least one inlet for the feed fluid and to at least one outlet for the retentate. The permeate collection channel is fluidly connected to at least one outlet for the permeate.Type: ApplicationFiled: October 3, 2018Publication date: January 31, 2019Inventors: Martin Leuthold, Ulrich Grummert, Peter Schmidt
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Patent number: 8453847Abstract: A filter cartridge unit including a first end plate, at least one second end plate, and a filter cartridge that is arranged between the end plates. The filter cartridge is connected, in a form-fitting and fluid-tight manner, to its adjacent end plates in a circumferential subarea of contact surfaces thereof using an adhesive.Type: GrantFiled: November 24, 2009Date of Patent: June 4, 2013Assignee: Sartorius Stedim Biotech GmbHInventors: Oscar-Werner Reif, Ulrich Grummert, Frank Oppermann
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Patent number: 8177972Abstract: An adapter is provided for fastening a filter element in a cylindrical receiving opening of a bottom part of a lower piece of a filter housing. The adapter has at least one seal arranged in a peripheral groove on the circumference of the adapter to permit fluid-tight separation of a non-filtrate chamber, which surrounds the external jacket of the filter and from which medium to be filtered can be delivered to the filter, from a filtrate chamber into which the filtrate can be introduced from the filter. The seal is connected by injection molding to a base surface of the peripheral groove and is at a distance from at least one side wall delimiting the base surface of the groove.Type: GrantFiled: May 27, 2009Date of Patent: May 15, 2012Assignee: Sartorius Stedim Biotech GmbHInventors: Ulrich Grummert, Ralf Lausch, Paschalis Nikoloudis, Christian Pradel, Michael Schuetzler
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Publication number: 20110100892Abstract: An adapter is provided for fastening a filter element in a cylindrical receiving opening of a bottom part of a lower piece of a filter housing. The adapter has at least one seal arranged in a peripheral groove on the circumference of the adapter to permit fluid-tight separation of a non-filtrate chamber, which surrounds the external jacket of the filter and from which medium to be filtered can be delivered to the filter, from a filtrate chamber into which the filtrate can be introduced from the filter. The seal is connected by injection molding to a base surface of the peripheral groove and is at a distance from at least one side wall delimiting the base surface of the groove.Type: ApplicationFiled: May 27, 2009Publication date: May 5, 2011Applicant: SARTORIUS STEDIM BIOTECH GMBHInventors: Ulrich Grummert, Ralf Lausch, Paschalis Nikoloudis, Christian Pradel, Michael Schuetzler
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Publication number: 20100072125Abstract: A filter cartridge unit including a first end plate, at least one second end plate, and a filter cartridge that is arranged between the end plates. The filter cartridge is connected, in a form-fitting and fluid-tight manner, to its adjacent end plates in a circumferential subarea of contact surfaces thereof using an adhesive.Type: ApplicationFiled: November 24, 2009Publication date: March 25, 2010Applicant: Sartorius Stedim Biotech GmbHInventors: Oscar-Werner REIF, Ulrich Grummert, Frank Oppermann
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Patent number: 7520988Abstract: An improved cross-flow filtration unit utilizing at least one two-ply membrane is disclosed that has a particular pore size relationship in the two membrane layers.Type: GrantFiled: November 20, 2006Date of Patent: April 21, 2009Assignee: Sartorius Stedim Biotech GmbHInventors: Ina Pahl, Hans-Weddo Schmidt, Ulrich Grummert
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Patent number: 7261817Abstract: The invention relates to a filter module and an apparatus for the static filtration of liquids using filter cells having deep bed filter layers and using spacer layers. According to the invention the filter module has a stack of n filter cells and n+1 spacer layers for filtrate and at least one channel arranged in the interior of the filter module. In this case n is ?1. The filter cells consist of a draining spacer layer for feed liquid and deep bed filter layers which are arranged in a sandwichlike manner thereto and which are joined to one another at their circumference toward the at least one channel at the rim via a sealing compound and wherein the spacer layers for filtrate are furnished with the sealing compound at the rim on their external circumference.Type: GrantFiled: July 2, 2004Date of Patent: August 28, 2007Assignee: Sartorius Biotech GmbHInventors: Willi Requate, Ulrich Grummert, Holger Linne, Pachalis Nikoloudis, Ralf Lausch, Oscar-Werner Reif
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Publication number: 20070062856Abstract: An improved cross-flow filtration unit utilizing at least one two-ply membrane is disclosed that has a particular pore size relationship in the two membrane layers.Type: ApplicationFiled: November 20, 2006Publication date: March 22, 2007Inventors: Ina Pahl, Hans-Weddo Schmidt, Ulrich Grummert
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Patent number: 6983504Abstract: A method for testing the integrity of filter elements, in which the convective component of the volumetric gas flow rate is determined from the ratio of the volumetric gas flow rates and the ratio of the solubility or diffusion coefficients of two different gases in the wetting liquid of the filter elements or is determined from the ratio of the volumetric gas flow rates and the ratio of the solubility or diffusion coefficients of a test gas in two different wetting liquids.Type: GrantFiled: October 2, 2003Date of Patent: January 10, 2006Assignee: Sartorius AGInventors: Ulrich Grummert, Ina Pahl
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Publication number: 20050242030Abstract: A device and a process are described for membrane electrophoresis or electrofiltration. The device contains at least one input chamber, one output chamber, and one cathode chamber and anode chamber each, whereby the individual chambers are separated from one another by membranes, and are integrated into a permanently attached module with membranes, and whereby the electrodes are integrated into the module, and the module is connected to constructions enabling continuous flow through the input and output chambers, as well as through the electrode chambers. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader quickly to ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the appended issued claims. 37 CFR ยง1.72(b).Type: ApplicationFiled: February 10, 2005Publication date: November 3, 2005Applicant: Bayer Technology Services GmbHInventors: Ralf Lausch, Oscar-Werner Reif, Ulrich Grummert, Stefan Haufe, Holger Linne, Andre Pastor, Gregor Dudziak, Andreas Nickel, Martina Mutter, Michael Traving
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Patent number: 6916420Abstract: An improved wide passage cross-flow filtration cassette is disclosed that incorporates an open mesh matrix retentate spacer that is dimensioned and oriented so as to improve flux and cause turbulence in the flow of fluids through the cassette.Type: GrantFiled: April 19, 2001Date of Patent: July 12, 2005Assignee: Sartorius AGInventors: Hans-Weddo Schmidt, Ulrich Grummert, Ina Pahl, Claudia Hartmann
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Publication number: 20050126980Abstract: An improved cross-flow filtration unit utilizing at least one two-ply membrane is disclosed that has a particular pore size relationship in the two membrane layers.Type: ApplicationFiled: December 21, 2000Publication date: June 16, 2005Inventors: Ina Pahl, Hans-Weddo Schmidt, Ulrich Grummert
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Patent number: 6893563Abstract: Cross-flow filters having improved uniformity in transmembrane pressures and consequent much greater flux are provided by the installation of barriers in permeate channels.Type: GrantFiled: May 30, 2001Date of Patent: May 17, 2005Assignee: Sartorius AGInventor: Ulrich Grummert