Patents by Inventor Ulrich Grundmann

Ulrich Grundmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of factor XIIIa by gene manipulation
    Patent number: 7220556
    Abstract: The cDNA which codes for factor XIIIa has been isolated using a cDNA bank from human placenta and probes constructed on the basis of the amino acid sequence of factor XIIIa peptide fragments. It is possible with this cDNA not only to obtain factor XIIIa by gene manipulation in high purity but also to prepare diagnostic aids which permit the analysis of genetic factor XIIIa defects. Furthermore, it is possible on the basis of the amino acid sequence to prepare antibodies which are suitable for diagnostic aids and antibody columns.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: May 22, 2007
    Assignee: ZLB Behring GmbH
    Inventors: Ulrich Grundmann, Egon Amann, Gerd Zettlmeissl
  • Preparation of DNA encoding factor XIIIA
    Patent number: 6869790
    Abstract: The cDNA which codes for factor XIIIa has been isolated using a cDNA bank from human placenta and probes constructed on the basis of the amino acid sequence of factor XIIIa peptide fragments. It is possible with this cDNA not only to obtain factor XIIIa by gene manipulation in high purity but also to prepare diagnostic aids which permit the analysis of genetic factor XIIIa defects. Furthermore, it is possible on the basis of the amino acid sequence to prepare antibodies which are suitable for diagnostic aids and antibody columns.
    Type: Grant
    Filed: March 12, 1993
    Date of Patent: March 22, 2005
    Assignee: Aventis Behring GmbH
    Inventors: Ulrich Grundmann, Egon Amann, Gerd Zettlmeissl
  • Preparation of factor XIIIa by gene manipulation
    Patent number: 6746866
    Abstract: The cDNA which codes for factor XIIIa has been isolated using a cDNA bank from human placenta and probes constructed on the basis of the amino acid sequence of factor XIIIa peptide fragments. It is possible with this cDNA not only to obtain factor XIIIa by gene manipulation in high purity but also to prepare diagnostic aids which permit the analysis of genetic factor XIIIa defects. Furthermore, it is possible on the basis of the amino acid sequence to prepare antibodies which are suitable for diagnostic aids and antibody columns.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: June 8, 2004
    Assignee: Aventis Behring GmbH
    Inventors: Ulrich Grundmann, Egon Amann, Gerd Zettlmeissl
  • Transgenic coagulation factor XIII defective animal and its use for testing wound healing and bleeding
    Patent number: 6207877
    Abstract: The invention provides a transgenic mouse which is heterozygous or homozygous for an at least partially defective coagulation factor XIII gene.
    Type: Grant
    Filed: September 23, 1999
    Date of Patent: March 27, 2001
    Assignee: Aventis Behring GmbH
    Inventors: Gerhard Dickneite, Hubert Metzner, Gerd Zettlmeissl, Ulrich Grundmann, Richard Lathe, Austin Smith, Meng Li
  • DNA encoding anticoagulative protein PP4-X, and its preparation and use
    Patent number: 5320950
    Abstract: The protein PP4-X, whose amino acid sequence and the DNA sequence coding for this have been determined, has anticoagulative properties and can be prepared by genetic manipulation. PP4-X is used for therapeutic and diagnostic purposes.
    Type: Grant
    Filed: December 4, 1992
    Date of Patent: June 14, 1994
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Ulrich Grundmann, Karl-Josef Abel, Egon Amann
  • Protein PP 15 preprared by genetic manipulation
    Patent number: 5317094
    Abstract: Specific fragments of the protein PP15 were prepared by enzyme cleavage. Using statistical data, specific oligonucleotides were selected from the oligonucleotides coding for the specific PP15 fragments. These oligonucleotides were then used as probes to successfully screen a cDNA bank of mature human placenta and isolate the complete cDNA of PP15. The cDNA was sequenced and characterized. This cDNA can be used to prepare PP15 protein in prokaryotic or eukaryotic cells.
    Type: Grant
    Filed: August 11, 1992
    Date of Patent: May 31, 1994
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Ulrich Grundmann, Karl-Josef Abel, Eugen Amann
  • Method of monitoring a pumping limit of a multistage turbocompressor with intermediate cooling
    Patent number: 5290142
    Abstract: A method of operating a multistage turbocompressor or of monitoring the pump limit thereof, whereby the pump limit function is stored in the control unit in the form Y=m.F+b and the coefficients m and b are determined by the linear relationshipsm=m.sub.0 +m.sub.1.dT.sub.s +.SIGMA.m.sub.2i.dT.sub.rib=b.sub.0 +b.sub.1.dT.sub.s +.SIGMA.b.sub.2i.dT.sub.riwhere T.sub.s and T.sub.ri represent the intake temperature and the backcooling temperatures following coolers after each turbocompressor and dT.sub.s and T.sub.ri and reference temperatures T.sub.ref. The system automatically compensates for the shift of the pump limit with temperature and allows operation closer to the pump limit or boundary for stable aerodynamic operation.
    Type: Grant
    Filed: September 29, 1992
    Date of Patent: March 1, 1994
    Assignee: Atlas Copco Energas GmbH
    Inventors: Ioan Ispas, Ulrich Grundmann, Yvan Van Hoof
  • Anticoagulative protein PP4-X
    Patent number: 5202419
    Abstract: The protein PP4-X, whose amino acid sequence and the DNA sequence coding for this have been determined, has anticoagulative properties and can be prepared by genetic manipulation. PP4-X is used for therapeutic and diagnostic purposes.
    Type: Grant
    Filed: February 28, 1992
    Date of Patent: April 13, 1993
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Ulrich Grundmann, Karl-Josef Abel, Egon Amann
  • Protein PP15 prepared by genetic manipulation
    Patent number: 5188933
    Abstract: The cDNA coding for PP15 is described. This cDNA can be used to prepare PP15 in pro- or eukaryotic cells.
    Type: Grant
    Filed: June 3, 1991
    Date of Patent: February 23, 1993
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Ulrich Grundmann, Karl-Josef Abel, Eugen Amann