Abstract: 4-Androsten-3-ones of the formula ##STR1## wherein R.sub.1 is hydrogen or the acyl radical of an organic or inorganic acid, R.sub.2 is hydrogen, alkyl, or the acyl radical of an organic or inorganic acid, R.sub.3 is methyl or ethyl, R.sub.4 is hydrogen or methyl, ##STR2## and R.sub.5 is lower alkyl, have diuretic activity.

Abstract: 3.alpha.-Hydroxy and 3.alpha.-acyloxy- .DELTA..sup.9(11) -5.alpha.-D-homo-20-ketopregnenes of the formula ##STR1## wherein R is hydrogen or acyl, R.sub.1 is hydrogen or methyl and R.sub.2 is methyl or ethyl, are produced by esterifying a corresponding 3.beta.-hydroxy-5.alpha.-20-keto pregnane of the formula ##STR2## wherein R.sub.1 and R.sub.2 have the values given above, with m-iodo-benzoic acid with inversion of the 3.beta.-oxy group to a 3.alpha.-oxy group; chlorinating the thus-produced 3.alpha.-m-iodobenzoyl ester with dichloroiodobenzene under irradiation; and treating the reaction product with a dehydrohalogenating silver salt. Optionally thereafter, the 3.alpha.-iodobenzoyl group is split off in a conventional manner to produce the corresponding 3.alpha.-hydroxy steroid and optionally the thus-produced 3.alpha.-hydroxy steroid is esterified to produce a desired 3-ester thereof.

Abstract: 3.alpha.-Hydroxy and 3.alpha.-acyloxy- .DELTA..sup.9(11) -5.alpha.-20-ketopregnenes of the formula ##STR1## wherein R is hydrogen or acyl, R.sub.1 is hydrogen or methyl and R.sub.2 is methyl or ethyl, are produced by esterifying a corresponding 3.beta.-hydroxy-5.alpha.-20-keto pregnane of the formula ##STR2## wherein R.sub.1 and R.sub.2 have the values given above, with m-iodobenzoic acid with inversion of the 3.beta.-oxy group to a 3.alpha.-oxy group; chlorinating the thus-produced 3.alpha.-m-iodobenzoyl ester with dichloroiodobenzene under irradiation; and treating the reaction product with a dehydrohalogenating silver salt. Optionally thereafter, the 3.alpha.-iodobenzoyl group is split off in a conventional manner to produce the corresponding 3.alpha.-hydroxy steroid and optionally the thus-produced 3.alpha.-hydroxy steroid is esterified to produce a desired 3-ester thereof.

Abstract: D-homo-20-ketopregnanes of the formula ##STR1## wherein R.sub.1 is hydrogen, fluorine, chlorine, bromine, alkyl, alkoxy, or azido;R.sub.2 is oxygen, ##STR2## and R.sub.7 is hydrogen, lower alkyl, or acyl of up to 5 carbon atoms; R.sub.3 is hydrogen or methylR.sub.4 is oxygen, two hydrogens, ##STR3## R.sub.5 is hydrogen, hydroxy, alkoxy, azido, mercapto, thiocyano, cyano, dialkylamino, morpholino, thiomorpholino, or piperazino;R.sub.6 is methyl or ethyl;The hydrogen atom in the 5-position is of the .alpha.- or .beta.-configuration;And acid addition salts thereof, possess narcotic-anesthetic activity.

Abstract: D-homo-20-ketopregnanes of the formula ##STR1## wherein R.sub.1 is oxygen, ##STR2## in which R.sub.5 is hydrogen or lower acyl; R.sub.2 is hydrogen or methyl; R.sub.3 is oxygen, ##STR3## or two hydrogen atoms; R.sub.4 is hydrogen, hydroxy or acyloxy; R.sub.6 is hydrogen or methyl; and R.sub.7 is hydrogen, acetyl, hydroxy or lower acyloxy in the .alpha.- or .beta.-position possess CNS-depressant activity, including anesthesia upon parenteral administration, and are produced by hydrogenating the corresponding steroids having double bonded C.sub.5 and/or C.sub.16 carbon atoms.

Abstract: D-Homo-21-carboxylic acids of the formula ##STR1## the represents a single bond or a double bond; X is a hydrogen atom, a fluorine atom, or methylene;Y is a hydrogen atom, a fluorine atom, or a chlorine atom;Z is methylene, carbonyl, .beta.-hydroxymethylene, a .beta.-alkanoyloxymethylene or when Y is a chlorine atom, also .beta.-fluoromethylene or .beta.-chloromethylene;R.sub.1 is a hydrogen atom or methyl; andR.sub.2 is a hydrogen atom, hydroxy or alkanoyloxy; and their physiologically acceptable salts with bases and the 21-esters thereof, possess topical anti-inflammatory activity.

Abstract: 18-Methyl-19-nor-20-keto steroids of the formula ##STR1## wherein R.sub.1 and R.sub.2 collectively are an oxygen atom, or each is hydrogen, or one of R.sub.1 and R.sub.2 is hydrogen and the other is hydroxy, and R.sub.3 is a ketonic oxygen atom or two hydrogen atoms, possess CNS-depressant activity, especially anesthetic-narcotic activity.

Abstract: The present disclosure relates to steroid carboxylic acids and derivatives thereof. More particularly, the disclosure is concerned with D-homosteroid carboxylic acids and their derivatives, a process for the preparation thereof and pharmaceutical compositions containing same. The instant compounds are active endocrinal agents, especially as antiinflammatory agents.

Abstract: The present invention relates to steroids. More particularly, the invention is concerned with D-homosteroids, a process for the manufacture thereof and pharmaceutical preparations containing same.

Abstract: Novel D-homosteroids of the formula ##STR1## are disclosed. These compounds exhibit anti-inflammatory activity.

Abstract: Novel D-homosteroids of the formula ##STR1## are disclosed. The novel D-homosteroids exhibit anti-inflammatory activity and are useful intermediates for the synthesis of anti-inflammatory D-homosteroids.

Abstract: The present disclosure relates to novel D-homo-pregnene steroids useful as progestational agents.

Abstract: D-homo steroids of the formula ##STR1## wherein X is H, F or CH.sub.3 ; Y is H, F or Cl; Z is CH.sub.2, CO, .beta.-HOCH.sub.2, .beta.-AcOCH.sub.2 or, when Y is Cl, also .beta.-FCH.sub.2 or .beta.-ClCH.sub.2 ; R.sub.1 is H or CH.sub.3, R.sub.2 is H, OH or AcO; and one of R.sub.3 and R.sub.4 is H and the other is OH or alkoxy or both are O, possess anti-inflammatory activity.

Abstract: D-Homosteroids of the formula ##SPC1##Wherein R.sup.3 .alpha. is hydrogen, R.sup.3 .beta. is hydrogen, lower alkanoyloxy or aroyloxy and R.sup.3 .alpha. and R.sup.3 .beta. taken together are oxo; R.sup.13 is lower alkyl; R.sup.17a .beta. is hydrogen, lower alkanoyl, aroyl or lower alkyl; R.sup.17a .alpha. is hydrogen, lower alkyl, ethynyl, 1-propynyl, vinyl, chloroethynyl, butadiynyl or propadienyl and the dotted line in the A-ring denotes an additional carbon bond in either the 4,5- or 5(10)-position and processes for the preparation thereof are disclosed.The D-homosteroids of the present invention are useful as contraceptives and regulators of the female menstrual cycle.

Abstract: New 6.beta.,7.beta.-epoxy-17.alpha.-hydroxy or acyloxy-1.alpha.,2.alpha.-methylen-D-homo-4-pregnen-3,20-diones having surprising progestational activity are disclosed.

Abstract: Steroids bearing the substituent --X-NR.sub.1 R.sub.2 wherein --NR.sub.1 R.sub.2 is a tritium of carbon-14 labeled amino or amino-acid group and --X-- is --R.sub.3 --, --OCOR.sub.3 --, =N--O--R.sub.3 -- or --NHCOR.sub.3 -- wherein R.sub.3 is --(CH.sub.2).sub.n CO-- in which n is 0-4, are useful as diagnostic agents.