Patents by Inventor Ulrich Koszinowski

Ulrich Koszinowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AAV-based conditional expression system
    Patent number: 11926841
    Abstract: The present invention relates to a cell comprising (aa) a nucleic acid comprising in 5? to 3? direction (i) at least one adeno-associated virus (AAV) inverted terminal repeat (ITR) sequence; (ii) a promoter which is capable of being activated by (a) helper polypeptide(s) and optionally (a) helper polynucleotide(s); and (iii) a transgenic coding sequence under the control of said promoter of (aa)(ii); and (ab) a nucleic acid comprising in 5? to 3? direction (i) a promoter which is capable of being activated by said helper polypeptide(s) and optionally said helper polynucleotide(s); and (ii) at least one AAV rep gene coding sequence under the control of said promoter of (ab)(i); wherein said cell does not comprise an AAV cap gene and/or is not able to express any AAV cap gene product.
    Type: Grant
    Filed: September 22, 2021
    Date of Patent: March 12, 2024
    Inventors: Ulrich Koszinowski, Simona Langer, Zsolt Ruzsics, Christian Thirion
  • AAV-BASED CONDITIONAL EXPRESSION SYSTEM
    Publication number: 20220073947
    Abstract: The present invention relates to a cell comprising (aa) a nucleic acid comprising in 5? to 3? direction (i) at least one adeno-associated virus (AAV) inverted terminal repeat (ITR) sequence; (ii) a promoter which is capable of being activated by (a) helper polypeptide(s) and optionally (a) helper polynucleotide(s); and (iii) a transgenic coding sequence under the control of said promoter of (aa)(ii); and (ab) a nucleic acid comprising in 5? to 3? direction (i) a promoter which is capable of being activated by said helper polypeptide(s) and optionally said helper polynucleotide(s); and (ii) at least one AAV rep gene coding sequence under the control of said promoter of (ab)(i); wherein said cell does not comprise an AAV cap gene and/or is not able to express any AAV cap gene product.
    Type: Application
    Filed: September 22, 2021
    Publication date: March 10, 2022
    Inventors: Ulrich KOSZINOWSKI, Simona LANGER, Zsolt RUZSICS, Christian THIRION
  • AAV-based conditional expression system
    Patent number: 11155831
    Abstract: The present invention relates to a cell comprising (aa) a nucleic acid comprising in 5? to 3? direction (i) at least one adeno-associated virus (AAV) inverted terminal repeat (ITR) sequence; (ii) a promoter which is capable of being activated by (a) helper polypeptide(s) and optionally (a) helper polynucleotide(s); and (iii) a transgenic coding sequence under the control of said promoter of (aa)(ii); and (ab) a nucleic acid comprising in 5? to 3? direction (i) a promoter which is capable of being activated by said helper polypeptide(s) and optionally said helper polynucleotide(s); and (ii) at least one AAV rep gene coding sequence under the control of said promoter of (ab)(i); wherein said cell does not comprise an AAV cap gene and/or is not able to express any AAV cap gene product.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: October 26, 2021
    Inventors: Ulrich Koszinowski, Simona Langer, Zsolt Ruzsics, Christian Thirion
  • Vaccine against beta-herpesvirus infection and use thereof
    Patent number: 10842863
    Abstract: The present invention is related to a beta-herpesvirus, wherein the beta-herpesvirus is spread-deficient.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: November 24, 2020
    Inventors: Christian Thirion, Ulrich Koszinowski, Christian A. Mohr, Zsolt Ruzsics
  • VACCINE AGAINST BETA-HERPESVIRUS INFECTION AND USE THEREOF
    Publication number: 20190117766
    Abstract: The present invention is related to a beta-herpesvirus, wherein the beta-herpesvirus is spread-deficient.
    Type: Application
    Filed: November 19, 2018
    Publication date: April 25, 2019
    Inventors: Christian Thirion, Ulrich Koszinowski, Christian A. Mohr, Zsolt Ruzsics
  • AAV-BASED CONDITIONAL EXPRESSION SYSTEM
    Publication number: 20190032082
    Abstract: The present invention relates to a cell comprising (aa) a nucleic acid comprising in 5? to 3? direction (i) at least one adeno-associated virus (AAV) inverted terminal repeat (ITR) sequence; (ii) a promoter which is capable of being activated by (a) helper polypeptide(s) and optionally (a) helper polynucleotide(s); and (iii) a transgenic coding sequence under the control of said promoter of (aa)(ii); and (ab) a nucleic acid comprising in 5? to 3? direction (i) a promoter which is capable of being activated by said helper polypeptide(s) and optionally said helper polynucleotide(s); and (ii) at least one AAV rep gene coding sequence under the control of said promoter of (ab)(i); wherein said cell does not comprise an AAV cap gene and/or is not able to express any AAV cap gene product.
    Type: Application
    Filed: January 30, 2017
    Publication date: January 31, 2019
    Inventors: Ulrich KOSZINOWSKI, Simona LANGER, Zsolt RUZSICS, Christian THIRION
  • VACCINE AGAINST BETA-HERPESVIRUS INFECTION AND USE THEREOF
    Publication number: 20150306210
    Abstract: The present invention is related to a beta-herpesvirus, wherein the beta-herpesvirus is spread-deficient.
    Type: Application
    Filed: June 9, 2015
    Publication date: October 29, 2015
    Inventors: Christian Thirion, Ulrich Koszinowski, Christian A. Mohr, Zsolt Ruzsics
  • Vaccine against beta-herpesvirus infection and use thereof
    Patent number: 9078867
    Abstract: The present invention is related to a beta-herpesvirus, wherein the beta-herpesvirus is spread-deficient.
    Type: Grant
    Filed: May 5, 2011
    Date of Patent: July 14, 2015
    Inventors: Christian Thirion, Ulrich Koszinowski, Christian A. Mohr, Zsolt Ruzsics
  • VACCINE AGAINST BETA-HERPESVIRUS INFECTION AND USE THEREOF
    Publication number: 20130202638
    Abstract: The present invention is related to a beta-herpesvirus, wherein the beta-herpesvirus is spread-deficient.
    Type: Application
    Filed: May 5, 2011
    Publication date: August 8, 2013
    Inventors: Christian Thirion, Ulrich Koszinowski, Christian A. Mohr, Zsolt Ruzsics