Abstract: A a cutter holder (1) for wedge-shaped microtome cutters (5), in particular of regrindable hard-metal or steel cutters or wedge-shaped blade holders, in the case of which a clamping jaw (2) is mounted pivotably on a base (4) for the purpose of setting he clearance angle of the microtome cutter (5). The cutter holder (1) has a single clamping jaw (2) which is open at the front and has a centrally arranged setscrew (6) for accommodating the microtome cutter (5). A thrust piece (8) is arranged between the microtome cutter (5) and the clamping jaw (2). The thrust piece (8) is connected in a nonpositive manner to the setscrew (6) for the purpose of clamping the microtome cutter (5). In the region of the cutting blade (5), the thrust piece (8) is equipped with a profile (9) of U-shaped design, so that the clamping force of the setscrew (6) is transmitted to two points of the microtome cutter (5).