Patents by Inventor Ulrich Reinhold

Ulrich Reinhold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aqueous pharmaceutical formulation of tapentadol for oral administration
    Patent number: 11547678
    Abstract: An aqueous pharmaceutical composition containing tapentadol or a physiologically acceptable salt thereof and being adapted for oral administration. The composition has excellent storage stability without relying on the presence of high amounts of preservatives.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: January 10, 2023
    Assignee: Gruenenthal GmbH
    Inventors: Ulrich Reinhold, Marc Schiller, Eva Wulsten, Sabine Karine Katrien Inghelbrecht, Roger Carolus Augusta Embrechts, Ulrich Feil
  • Stable formulation for parenteral administration of tapentadol
    Patent number: 11013701
    Abstract: The invention relates to an aqueous pharmaceutical composition for parenteral administration comprising Tapentadol or a physiologically acceptable salt thereof, wherein the concentration of Tapentadol is within the range of from 0.10 to 8.00 mg/mL, based on the weight of Tapentadol free base and based on the total volume of the composition; and wherein the pH value of the composition is buffered and within the range of from 4.0 to 6.0. The invention also relates to a container comprising the pharmaceutical composition and a process for the preparation thereof. The invention also relates to a kit comprising the contained according to the invention in a packaging. The pharmaceutical composition according to the invention is particularly useful for treating pain, especially acute pain, preferably in pediatric patients.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: May 25, 2021
    Assignee: Grünenthal GmbH
    Inventors: Marc Schiller, Carlos van Hemelrijck, Stefanie Straub, Eva Wulsten, Ulrike Bertram, Ulrich Reinhold
  • Stable formulation for parenteral administration of Tapentadol
    Patent number: 10898452
    Abstract: The invention relates to an an aqueous pharmaceutical composition for parenteral administration comprising Tapentadol or a physiologically acceptable salt thereof; wherein the concentration of Tapentadol is greater than 8.00 mg/mL, based on the weight of Tapentadol free base and based on the total volume of the composition; wherein the composition comprises a buffer system; and wherein the pH value of the composition is within the range of from greater than 3.0 to less than 6.7. The invention also relates to a kit comprising the composition according to the invention in a packaging. The pharmaceutical composition according to the invention is particularly useful for treating pain, especially acute pain, preferably in adult patients.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: January 26, 2021
    Assignee: GRUENENTHAL GMBH
    Inventors: Angelika Ellermann, Ulrich Reinhold, Ulrike Bertram
  • PARENTERAL ADMINISTRATION OF TAPENTADOL
    Publication number: 20200215003
    Abstract: An aqueous pharmaceutical composition adapted for parenteral administration of tapentadol or a physiologically acceptable salt thereof having a pH value of at least 5.4.
    Type: Application
    Filed: March 13, 2020
    Publication date: July 9, 2020
    Applicant: GRÜNENTHAL GMBH
    Inventors: Thomas CHRISTOPH, Sabine Karine Katrien INGHELBRECHT, Roger Carolus Augusta EMBRECHTS, Ulrich REINHOLD, Marc SCHILLER, Eva WULSTEN, Petra BLOMS-FUNKE, Klaus SCHIENE, Ulrich FEIL
  • AQUEOUS PHARMACEUTICAL FORMULATION OF TAPENTADOL FOR ORAL ADMINISTRATION
    Publication number: 20200054584
    Abstract: An aqueous pharmaceutical composition containing tapentadol or a physiologically acceptable salt thereof and being adapted for oral administration. The composition has excellent storage stability without relying on the presence of high amounts of preservatives.
    Type: Application
    Filed: October 24, 2019
    Publication date: February 20, 2020
    Applicant: GRÜNENTHAN GMBH
    Inventors: Ulrich REINHOLD, Marc SCHILLER, Eva WULSTEN, Sabine Karine Katrien INGHELBRECHT, Roger Carolus Augusta EMBRECHTS, Ulrich FEIL
  • MULTIPARTICULATE ORAL DOSAGE FORM PROVIDING PROLONGED RELEASE OF TAPENTADOL
    Publication number: 20180369151
    Abstract: The invention relates to an oral pharmaceutical dosage form comprising a plurality of coated particles, wherein said coated particles comprise a core which comprises a Tapentadol component and which is coated with a controlled release coating material, wherein the controlled release coating material comprises a lubricant component and a polymer component, wherein the polymer component comprises one or more cellulose ethers and/or one or more acrylates, and wherein the pharmaceutical dosage form provides controlled release of the Tapentadol component.
    Type: Application
    Filed: May 29, 2018
    Publication date: December 27, 2018
    Applicant: GRÜNENTHAL GMBH
    Inventors: Marc SCHILLER, Ulrich REINHOLD, Ulrike BERTRAM, Wolfgang PRANGE, Anika-Anina PHILIPP, Stefanie STRAUB, Annette GRAVE, Norbert POELLINGER
  • Semisolid Aqueous Pharmaceutical Composition Containing Tapentadol
    Publication number: 20180133174
    Abstract: A semisolid aqueous pharmaceutical composition containing tapentadol or a physiologically acceptable salt thereof.
    Type: Application
    Filed: January 10, 2018
    Publication date: May 17, 2018
    Inventors: Ulrich REINHOLD, Marc SCHILLER, Eva WULSTEN, Sabine Karine Katrien INGHELBRECHT, Roger Carolus Augusta EMBRECHTS, Ulrich FEIL
  • Stable Formulation for Parenteral Administration of Tapentadol
    Publication number: 20180125800
    Abstract: The invention relates to an aqueous pharmaceutical composition for parenteral administration comprising Tapentadol or a physiologically acceptable salt thereof, wherein the concentration of Tapentadol is within the range of from 0.10 to 8.00 mg/mL, based on the weight of Tapentadol free base and based on the total volume of the composition; and wherein the pH value of the composition is buffered and within the range of from 4.0 to 6.0. The invention also relates to a container comprising the pharmaceutical composition and a process for the preparation thereof. The invention also relates to a kit comprising the contained according to the invention in a packaging. The pharmaceutical composition according to the invention is particularly useful for treating pain, especially acute pain, preferably in pediatric patients.
    Type: Application
    Filed: January 10, 2018
    Publication date: May 10, 2018
    Inventors: Marc SCHILLER, Carlos van Hemelrijck, Stefanie STRAUB, Eva WULSTEN, Ulrike BERTRAM, Ulrich REINHOLD
  • Stable Formulation for Parenteral Administration of Tapentadol
    Publication number: 20180085328
    Abstract: The invention relates to an an aqueous pharmaceutical composition for parenteral administration comprising Tapentadol or a physiologically acceptable salt thereof; wherein the concentration of Tapentadol is greater than 8.00 mg/mL, based on the weight of Tapentadol free base and based on the total volume of the composition; wherein the composition comprises a buffer system; and wherein the pH value of the composition is within the range of from greater than 3.0 to less than 6.7. The invention also relates to a kit comprising the composition according to the invention in a packaging. The pharmaceutical composition according to the invention is particularly useful for treating pain, especially acute pain, preferably in adult patients.
    Type: Application
    Filed: September 22, 2017
    Publication date: March 29, 2018
    Inventors: Angelika ELLERMANN, Ulrich REINHOLD, Ulrike BERTRAM
  • Semisolid Aqueous Pharmaceutical Composition Containing Tapentadol
    Publication number: 20160346229
    Abstract: A semisolid aqueous pharmaceutical composition containing tapentadol or a physiologically acceptable salt thereof.
    Type: Application
    Filed: August 10, 2016
    Publication date: December 1, 2016
    Inventors: Ulrich REINHOLD, Marc SCHILLER, Eva WULSTEN, Sabine Karine Katrien INGHELBRECHT, Roger Carolus Augusta EMBRECHTS, Ulrich FEIL
  • Stable Formulation for Parenteral Administration of Tapentadol
    Publication number: 20160279078
    Abstract: The invention relates to an aqueous pharmaceutical composition for parenteral administration comprising Tapentadol or a physiologically acceptable salt thereof, wherein the concentration of Tapentadol is within the range of from 0.10 to 8.00 mg/mL, based on the weight of Tapentadol free base and based on the total volume of the composition; and wherein the pH value of the composition is buffered and within the range of from 4.0 to 6.0. The invention also relates to a container comprising the pharmaceutical composition and a process for the preparation thereof. The invention also relates to a kit comprising the contained according to the invention in a packaging. The pharmaceutical composition according to the invention is particularly useful for treating pain, especially acute pain, preferably in pediatric patients.
    Type: Application
    Filed: March 23, 2016
    Publication date: September 29, 2016
    Inventors: Marc SCHILLER, Carlos van Hemelrijck, Stefanie STRAUB, Eva WULSTEN, Ulrike BERTRAM, Ulrich REINHOLD
  • Semisolid aqueous pharmaceutical composition containing tapentadol
    Patent number: 9446008
    Abstract: A semisolid aqueous pharmaceutical composition containing tapentadol or a physiologically acceptable salt thereof.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: September 20, 2016
    Assignee: Gruenenthal GmbH
    Inventors: Ulrich Reinhold, Marc Schiller, Eva Wulsten, Sabine Karine Katrien Inghelbrecht, Roger Carolus Augusta Embrechts, Ulrich Feil
  • Aqueous Pharmaceutical Formulation of Tapentadol for Oral Administration
    Publication number: 20160220516
    Abstract: An aqueous pharmaceutical composition containing tapentadol or a physiologically acceptable salt thereof and being adapted for oral administration. The composition has excellent storage stability without relying on the presence of high amounts of preservatives.
    Type: Application
    Filed: April 7, 2016
    Publication date: August 4, 2016
    Inventors: Ulrich REINHOLD, Marc SCHILLER, Eva WULSTEN, Sabine Karine Katrien INGHELBRECHT, Roger Carolus Augusta EMBRECHTS, Ulrich FEIL
  • Parenteral Administration of Tapentadol
    Publication number: 20160106688
    Abstract: An aqueous pharmaceutical composition adapted for parenteral administration of tapentadol or a physiologically acceptable salt thereof having a pH value of at least 5.4.
    Type: Application
    Filed: December 28, 2015
    Publication date: April 21, 2016
    Inventors: Thomas CHRISTOPH, Sabine Karine Katrien INGHELBRECHT, Roger Carolus Augusta EMBRECHTS, Ulrich REINHOLD, Marc SCHILLER, Eva WULSTEN, Petra BLOMS-FUNKE, Klaus SCHIENE, Ulrich FEIL
  • SOLID PHARMACEUTICAL DOSAGE FORM
    Publication number: 20140179721
    Abstract: A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-soluble polymer and at least one pharmaceutically acceptable surfactant, said pharmaceutically acceptable water-soluble polymer having a Tg of at least about 5° C. Preferably, the pharmaceutically acceptable surfactant has an HLB value of from about 4 to about 10.
    Type: Application
    Filed: February 26, 2014
    Publication date: June 26, 2014
    Inventors: Joerg Rosenberg, Ulrich Reinhold, Bernd Liepold, Gunther Berndl, Joerg Breitenbach, Laman Alani, Soumojeet Ghosh
  • Solid pharmaceutical dosage form
    Patent number: 8691878
    Abstract: A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-soluble polymer and at least one pharmaceutically acceptable surfactant, said pharmaceutically acceptable water-soluble polymer having a Tg of at least about 50° C. Preferably, the pharmaceutically acceptable surfactant has an HLB value of from about 4 to about 10.
    Type: Grant
    Filed: November 12, 2012
    Date of Patent: April 8, 2014
    Assignee: AbbVie Inc.
    Inventors: Jeorg Rosenberg, Ulrich Reinhold, Bernd Liepold, Gunther Berndl, Joerg Breitenbach, Laman Alani, Soumojeet Ghosh
  • Solid pharmaceutical dosage form
    Patent number: 8399015
    Abstract: A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-soluble polymer and at least one pharmaceutically acceptable surfactant, said pharmaceutically acceptable water-soluble polymer having a Tg of at least about 50° C. Preferably, the pharmaceutically acceptable surfactant has an HLB value of from about 4 to about 10.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: March 19, 2013
    Assignee: AbbVie Inc.
    Inventors: Joerg Rosenberg, Ulrich Reinhold, Bernd Liepold, Gunther Berndl, Joerg Breitenbach, Laman Alani, Soumojeet Ghosh
  • Solid pharmaceutical dosage formulation
    Patent number: 8377952
    Abstract: The present invention provides a pharmaceutical dosage formulation, and more particularly, to a pharmaceutical dosage formulation comprising an HIV protease inhibitor.
    Type: Grant
    Filed: February 23, 2005
    Date of Patent: February 19, 2013
    Assignee: Abbott Laboratories
    Inventors: Jöerg Rosenberg, Ulrich Reinhold, Bernd Liepold, Gunther Berndl, Jörg Breitenbach, Laman L. Alani, Soumojeet Ghosh
  • Aqueous Pharmaceutical Formulation of Tapentadol for Oral Administration
    Publication number: 20130022670
    Abstract: An aqueous pharmaceutical composition containing tapentadol or a physiologically acceptable salt thereof and being adapted for oral administration. The composition has excellent storage stability without relying on the presence of high amounts of preservatives.
    Type: Application
    Filed: March 2, 2012
    Publication date: January 24, 2013
    Applicant: Gruenenthal GmbH
    Inventors: Ulrich REINHOLD, Marc Schiller, Eva Wulsten, Sabine Karine Katrien Inghelbrecht, Roger Carolus Augusta Embrechts
  • Solid Pharmaceutical Dosage Formulation
    Publication number: 20130004578
    Abstract: The present invention provides a pharmaceutical dosage formulation, and more particularly, a pharmaceutical dosage formulation comprising an HIV protease inhibitor.
    Type: Application
    Filed: September 10, 2012
    Publication date: January 3, 2013
    Applicant: ABBVIE INC.
    Inventors: Jörg Rosenberg, Ulrich Reinhold, Bernd Liepold, Gunther Berndl, Jörg Breitenbach, Laman Alani, Soumojeet Ghosh