Patents by Inventor Ulrich Schotten

Ulrich Schotten has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210239712
    Abstract: The present invention relates to a method for assessing atrial fibrillation in a subject, said method comprising the steps of determining the amount of FGFBP-1 in a sample from the subject, and comparing the amount of FGFBP-1 to a reference amount, whereby atrial fibrillation is to be assessed. Moreover, the present invention relates to methods for the prediction of stroke based on the amount of FGFBP-1.
    Type: Application
    Filed: February 22, 2021
    Publication date: August 5, 2021
    Inventors: Peter Kastner, Andre Ziegler, Ursula-Henrike Wienhues-Thelen, Vinzent Rolny, Manuel Dietrich, Ulrich Schotten
  • Publication number: 20210215716
    Abstract: The present invention relates to a method for assessing atrial fibrillation in a subject, said method comprising the steps of determining the amount of SPON-1 in a sample from the subject, and comparing the amount of SPON-1 to a reference amount, whereby atrial fibrillation is to be assessed. Moreover, the present invention relates to methods for the prediction of stroke based on the amount of SPON-1.
    Type: Application
    Filed: February 22, 2021
    Publication date: July 15, 2021
    Applicants: Roche Diagnostics Operations, Inc., Universiteit Maastricht, Academisch Ziekenhuis Maastricht
    Inventors: Peter Kastner, Manuel Dietrich, André Ziegler, Ursula-Henrike Wienhues-Thelen, Vinzent Rolny, Ulrich Schotten
  • Publication number: 20210190801
    Abstract: The present invention relates to a method for assessing atrial fibrillation in a subject, said method comprising the steps of determining the amount of BMP 10 in a sample from the subject, and comparing the amount of BMP 10 to a reference amount, whereby atrial fibrillation is to be assessed. Moreover, the present invention relates to a method for diagnosing heart failure based on the determination of BMP 10 in a sample from a subject. Further, the present invention relates to a method for predicting the risk of a subject of hospitalization due to heart failure based on the determination of a BMP 10-type peptide in a sample from a subject.
    Type: Application
    Filed: February 17, 2021
    Publication date: June 24, 2021
    Inventors: Johann Karl, Peter Kastner, Ursula-Henrike Wienhues-Thelen, Manuel Dietrich, Andre Ziegler, Ulrich Schotten
  • Publication number: 20210181211
    Abstract: The present invention relates to a method for assessing atrial fibrillation in a subject, said method comprising the steps of determining the amount of TFPI-2 in a sample from the subject, and comparing the amount of TFPI-2 to a reference amount, whereby atrial fibrillation is to be assessed. Moreover, the present invention relates to methods for assessing anticoagulation therapy and to methods for predicting the risk of stroke of a subject. Said methods are based on the determination of the amount of TFPI-2 in a sample from the subject.
    Type: Application
    Filed: February 16, 2021
    Publication date: June 17, 2021
    Inventors: Peter Kastner, Andre Ziegler, Ursula-Henrike Wienhues-Thelen, Vinzent Rolny, Manuel Dietrich, Ulrich Schotten
  • Publication number: 20210172962
    Abstract: The present invention relates to a method for assessing the risk of stroke in a subject, said method comprising the steps of determining the amount of CES-2 in a sample from the subject, and comparing the amount of CES-2 to a reference amount, whereby the risk of stroke is to be assessed. Moreover, the present invention relates to a method for assessing the efficacy of an anticoagulation therapy and a method for identifying a subject being eligible to the administration of at least one anticoagulation medicament or being eligible for increasing the dosage of at least one anticoagulation medicament.
    Type: Application
    Filed: February 10, 2021
    Publication date: June 10, 2021
    Inventors: Manuel Dietrich, Peter Kastner, Vinzent Rolny, Ulrich Schotten, Ursula-Henrike Wienhues-Thelen, Andre Ziegler
  • Publication number: 20210156875
    Abstract: The present invention relates to a method for assessing atrial fibrillation in a subject, said method comprising the steps of determining the amount of DKK3 in a sample from the subject, and comparing the amount of DKK3 to a reference amount, whereby atrial fibrillation is to be assessed. Moreover, the present invention relates to a method for diagnosing heart failure and/or at least one structural or functional abnormality of the heart associated with heart failure.
    Type: Application
    Filed: January 29, 2021
    Publication date: May 27, 2021
    Applicants: Roche Diagnostics Operations, Inc., Universitaet Maastricht, Academisch Ziekenhuis Maastricht
    Inventors: Johann Karl, Peter Kastner, Roberto Latini, Vinzent Rolny, Ursula-Henrike Wienhues-Thelen, Andre Ziegler, Manuel Dietrich, Jennifer Meessen, Ulrich Schotten
  • Publication number: 20200116708
    Abstract: Disclosed is a method for diagnosing paroxysmal atrial fibrillation in a subject, involving: determining the amount of FABP-3 (Fatty acid binding protein 3) in a sample from a subject suspected to suffer from paroxysmal atrial fibrillation, and comparing the determined amount to a reference amount. The method may further involve the determination of a BNP-type peptide. Also disclosed is a device adapted to carry out the method.
    Type: Application
    Filed: December 12, 2019
    Publication date: April 16, 2020
    Applicants: Roche Diagnostics Operations, Inc., Maastricht University Medical Center
    Inventors: Johann Karl, Peter Kastner, Vinzent Rolny, Ursula-Henrike Wienhues-Thelen, Manuel Dietrich, Andre Ziegler, Ulrich Schotten
  • Publication number: 20190162737
    Abstract: The present invention relates to a method for assessing atrial fibrillation in a subject, said method comprising the steps of determining the amount of ESM-1 in a sample from the subject, and comparing the amount of ESM-1 to a reference amount, whereby atrial fibrillation is to be assessed. Moreover, the present invention relates to a method for diagnosing heart failure and/or at least one structural or functional abnormality of the heart associated with heart failure.
    Type: Application
    Filed: February 1, 2019
    Publication date: May 30, 2019
    Applicants: Roche Diagnostics Operations, Inc., Maastricht University Medical Center
    Inventors: Johann Karl, Peter Kastner, Roberto Latini, Serge Masson, Ursula-Henrike Wienhues-Thelen, Andre Ziegler, Manuel Dietrich, Ulrich Schotten, Vinzent Rolny
  • Patent number: 9138159
    Abstract: The invention relates to a computer-implemented method for determining an AF complexity value. The method includes applying a template matching algorithm to an ECG signal to obtain a set of candidate deflections and identifying intrinsic deflections within the set of candidate deflections. The method further includes determining a number of intrinsic deflections and a number of far-field deflections within the set of candidate deflections, based on the identified intrinsic deflections, and determining the AF complexity value as a ratio between the number of far-field deflections and the number of intrinsic deflections.
    Type: Grant
    Filed: May 22, 2012
    Date of Patent: September 22, 2015
    Assignee: Maastricht University
    Inventors: Ulrich Schotten, Stef Zeemering, Bart Maesen
  • Publication number: 20150038863
    Abstract: The invention relates to a computer-implemented method for determining an AF complexity value. The method includes applying a template matching algorithm to an ECG signal to obtain a set of candidate deflections and identifying intrinsic deflections within the set of candidate deflections. The method further includes determining a number of intrinsic deflections and a number of far-field deflections within the set of candidate deflections, based on the identified intrinsic deflections, and determining the AF complexity value as a ratio between the number of far-field deflections and the number of intrinsic deflections.
    Type: Application
    Filed: May 22, 2012
    Publication date: February 5, 2015
    Applicant: MAASTRICHT UNIVERSITY
    Inventors: Ulrich Schotten, Stef Zeemering, Bart Maesen